Telomere: Stanford-Duke Cardiology Symposium
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Dear Helen,
Thank you for your excellent and far-reaching Stanford-Duke Cardiovascular Research Symposium talk "The Long and the Short of it: Telomere Length as a Hallmark of Cardiac Failure" yesterday - http://med.stanford.edu/cvi/mission/upcoming-events/stanford-duke-cv-research-symposium-2018.html (http://med.stanford.edu/content/dam/sm/cvi/documents/pdf/stanford-duke-program-2018.pdf).
Here's MIT Media Lab Director Joi Ito and per Harvard's George Church and gene editing - https://web.archive.org/web/20180605002848/https://www.wired.com/story/the-responsibility-of-immortality/ - and re longevity (and the wiki subject for this at MIT OCW-centric wiki World University and School - https://wiki.worlduniversityandschool.org/wiki/Longevity - of which I'm the startup founder), - re the longevity article mentioning telomeres which I mentioned. With regard to "Eternal youth, eternal old age, or having our cryogenically frozen brains thawed out 2,000 years," George Church is doing gene editing research now with dogs, having moved on from mice, as well as mentioning 9 main scientific approaches to longevity:
"He is currently experimenting with age reversal in dogs using gene therapy that has been successful in mice, a technique he believes is the most promising of nine broad approaches to mortality and aging—genome stability, telomere extension, epigenetics, proteostasis, caloric restriction, mitochondrial research, cell senescence, stem cell exhaustion, and intercellular communication"
(https://scott-macleod.blogspot.com/2018/08/cardoon-freeuniversaleducation-at-wuas.html).
The prospect of many people living beyond the 122 years of the longest known living person (Jeanne Calment) is fascinating in terms of especially emergent social problems per Joi Ito's article, "The Responsibility of Immortality: Welcome to the New Transhumanism" - https://web.archive.org/web/20180605002848/https://www.wired.com/story/the-responsibility-of-immortality/. I wonder if a realistic virtual earth with avatars bots for planning purposes could help (https://scott-macleod.blogspot.com/2018/08/auk-what-is-arcore-by-google-you-can.html), and am thinking here Google Street View with TIME Slider / Maps / Earth / TensorFlow - at the cellular and atomic levels with all species and even all individual organisms, conceptually - for STEM research, clinical care, and as medical school / research classrooms.
I'm curious especially how your approaches to studying telomeres, and the 8 other ways to study longevity mentioned in this article will all emerge in such a SINGLE realistic virtual earth for STEM research, and even in collaboration with something like Project Baseline.
What do you think? And what please is the name of the researcher you mentioned?
Very nice to talk with you and thank you for your excellent and exciting presentation.
Best regards, Scott
P.S.
Here are some related Tweets about your recent Stanford-Duke talks/work -
“Stem cell reserve is needed for repair of skeletal muscle defect in Duchenne’s muscular dystrophy” says Helen Blau @ #Stanfordduke2018@stanford@StanfordMed@StanfordCVI@StanfordDeptMed@StanCVFellows@DukeU@DukeCardiologypic.twitter.com/bPzo2dYMfv— Sean M Wu (@SeanM_Wu) November 30, 2018
https://twitter.com/SeanM_Wu/status/1068568418587004928
https://twitter.com/SeanM_Wu/status/1068568418587004928
https://twitter.com/StanfordCVI/status/1068281117378150400
https://twitter.com/StanfordCVI/status/1068566820745932800
https://twitter.com/euanashley/status/1036845241511292928
https://twitter.com/hashtag/HelenBlau?src=hash
Thanks #HelenBlau for your excellent and far-reaching Stanford-Duke talk "The Long and the Short of it: Telomere Length as a Hallmark of Cardiac Failure" https://twitter.com/SeanM_Wu/status/1068568418587004928 - https://twitter.com/SeanM_Wu/status/1068568418587004928 -https://twitter.com/StanfordCVI/status/1068281117378150400 -https://twitter.com/StanfordCVI/status/1068566820745932800 Project Baseline research?
Thanks #HelenBlau for your excellent and far-reaching Stanford-Duke talk "The Long and the Short of it: Telomere Length as a Hallmark of Cardiac Failure"https://t.co/ckZbD52PRs - https://t.co/ckZbD52PRs -https://t.co/KA7eLwH78O -https://t.co/lilYoKbFh6 Project Baseline research?— WorldUnivandSch (@WorldUnivAndSch) December 1, 2018
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- Scott MacLeod - Founder, President & Professor
- World University and School
- http://worlduniversityandschool.org
- 415 480 4577
- http://scottmacleod.com
- CC World University and School - like CC Wikipedia with best STEM-centric CC OpenCourseWare - incorporated as a nonprofit university and school in California, and is a U.S. 501 (c) (3) tax-exempt educational organization.
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Dear Svati, Rob, and Bob,
Project Baseline: Return of Results - Seek and Ye Shall Find
Svati Shah, MD, MHS
Vice-Chair of Translational Research
Associate Professor of Medicine
Duke University
svati.shah@duke.edu
https://dmpi.duke.edu/faculty/svati-h-shah-md-mhs
Rob Califf MD - Duke
https://medicine.duke.edu/faculty/robert-m-califf
Bob Harrington MD - Stanford
https://profiles.stanford.edu/robert-harrington
Project Baseline: Return of Results - Seek and Ye Shall Find
Svati Shah, MD, MHS
Vice-Chair of Translational Research
Associate Professor of Medicine
Duke University
svati.shah@duke.edu
https://dmpi.duke.edu/faculty/svati-h-shah-md-mhs
Rob Califf MD - Duke
https://medicine.duke.edu/faculty/robert-m-califf
Bob Harrington MD - Stanford
https://profiles.stanford.edu/robert-harrington
Thank you, Svati, for your excellent and far-reaching Stanford-Duke Cardiovascular Research Symposium talk, "Project Baseline: Return of Results - Seek and Ye Shall Find" yesterday - http://med.stanford.edu/cvi/
In talking with Svati after her great presentation about Project Baseline and communicating results, she encouraged me to email you, Rob, as co-founder of Project Baseline (and re our communication after your UCSF talk in April 2018 here - https://scott-macleod.
What I was mentioning and curious about, Svati, has to do with exploring how
A
i) Project Baseline might develop into online hospitals for clinical care in ~10 years (possibly longer or less time).
ii) How Baseline might develop into a comprehensive STEM Medical research site as well, and as a SINGLE realistic virtual earth (part of the Google platform/ecosystem - I'm thinking here Google Street View with time slider / Maps / Earth / Brain / TensorFlow - and at the cellular and atomic levels+) - for everything actually.
iii) And how Baseline might also develop into avatar bots eventually for actual-virtual, physical-digital direct correspondence, and for even tele-robotic surgery - and potentially for all species and all organisms, a ginormous data vision and project. This would include potentially eventually even the possibility of virtual gene editing (CRISPR into Baseline/StreetView?) and genomics, so that per Rob's recent Tweet that "Genetically Modified People Are Walking Among Us" - https://twitter.com/califf001/
Communication here would include completely new forms of publishing, including participant communications, as well as patient records, from within such a Project Baseline realistic virtual earth as hospital.
B
I also mentioned, as a heads' up, Svati, the possibility of
i) Project ECHO (MD specialists to rural populations with a mentoring aspect in group video) becoming online medical schools in ~10 years (more or less)
ii) with NEJM Continuing Education Modules (CME) as a basis for the first 2 years of online course ware - and subsequently translated into ~200 countries' official / main languages, for online Medical Schools
C)
In developing MIT OCW-centric World University and School (of which I'm the startup founder), WUaS seeks to develop online Medical Schools with online teaching hospitals for online clinical care. And in WUaS's new wiki, and in developing "World University and School: Online Medical Schools and Teaching Hospitals in ~200 countries’ official languages," and re - https://wiki.
D)
And here's an example of how this might work in Zimbabwe in Africa with a specific disease in this blog post:
Claytonia virginica: online Zimbabwe Medical School with online Teaching Hospital for Clinical Care, Stanford Africa Table "Human Papillomavirus Screening in Rural Zimbabwe," April 25 2018, Thanks too for replying, in response to my question, that Zimbabweans are hungry for medical education, Google/Verily's and Stanford and Duke's Project Baseline and eventually into a map for health for Zimbabweans, Concerning the realistic virtual earth for STEM research, I mentioned - think Google Street View with time slider / Maps / Earth / Translate / TensorFlow / Brain - and at the cellular and atomic levels too, possibly emerging out of Google's Project Baseline itself - online hospitals might emerge uniquely in this in the future, and even with avatar bots (that correspond to the 10,000 real participants in Project Baseline) for clinical care, research, bioengineering, genetic therapies, and eventually even actual-virtual remote tele-robotic surgery
E)
And such a Project Baseline hospital in a realistic virtual earth could even be developed for clinical trials - with speakers of all 7,097 living languages - https://scott-macleod.
F)
You'll find further, mostly Stanford, talks about Project Baseline and Project ECHO in this compendium blog post - https://scott-macleod.
Very nice to talk with you Svati (and Bob), and looking forward to further communication about this re this remarkable Duke-Stanford collaboration and with great regard to Project Baseline.
All the best,
Scott
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- Scott MacLeod - Founder, President & Professor
- World University and School
- 415 480 4577
- CC World University and School - like CC Wikipedia with best STEM-centric CC OpenCourseWare - incorporated as a nonprofit university and school in California, and is a U.S. 501 (c) (3) tax-exempt educational organization.
Stanford-Duke & Project Baseline: Thanks @SvatiShah for your "Project Baseline: Return of Results" talk. And thanks #HelenBlau too for your "The Long and the Short of it: Telomere Length as a Hallmark of Cardiac Failure" talk, LONGEVITY research too? SEE https://scott-macleod.blogspot.com/2018/12/telomere-thanks-helenblau-for-your.html ~
Stanford-Duke & Project Baseline: Thanks @SvatiShah for your "Project Baseline: Return of Results" talk. And thanks #HelenBlau too for your "The Long and the Short of it: Telomere Length as a Hallmark of Cardiac Failure" talk, LONGEVITY research too? SEE https://t.co/4QanTSFfxH ~— WorldUnivandSch (@WorldUnivAndSch) December 2, 2018
https://twitter.com/WorldUnivAndSch/status/1069303323545632768
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