Puritan tiger beetle (and Northeastern tiger beetle): On @WorldUnivAndSch's #WIKI side planned in all 7139 known living languages for open teaching & learning - where YOU can NOW TEACH- #WUaS seeks to hire teachers to grow communities in each language & to teach how further: https://wiki.worlduniversityandschool.org/wiki/Subjects https://wiki.worlduniversityandschool.org/wiki/Languages #WUaSwiki ~ * * * Some pics from my trip, SF Bay Area to Cuttyhunk, - Fort Fred Steele in Wyoming, to Mitchellville, Iowa, to Pittsburgh, & State College, Pennsylvania, to Hartford, Connecticut ...

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https://photos.app.goo.gl/mewnNzkP4rS7gb5z8 

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Scott MacLeod <sgkmacleod@worlduniversityandschool.org>	4:40 PM (5 hours ago)
to Elinor.Karlsson, gchurch

Dear Elinor, 

Greetings from Cuttyhunk island, Massachusetts, south of New Bedford. I'm writing to follow up on my email from April to inquire whether you might like to meet for a coffee or similar sometime around the weekend of F 7/16 & Sa 7/17 when I'm planning to head off island to visit friends in New Hampshire, one from high school. As you know, am developing CC-4 MIT OCW-centric wiki World Univ & Sch, and it would be great to meet as acquaintances and colleagues to chat about this and your Genetics' work. 

I realize you study vertebrates genetically, but I think you'd have much knowledge genetically which could be applied to invertebrates such as Drosophila. I wonder too how the possible doubling of the lifespan of a single Drosophila fly to say 180 days - and virtually with A G C Ts (say in a realistic virtual earth for genetics, with machine learning) - could be applied to dogs, and also digitally.

http://karlssonlab.org/author/karlssonlab/

https://youtu.be/YKjYFydrje0 

https://www.google.com/amp/s/alyzenmoonshadowdotcom.wordpress.com/2016/01/18/the-genetic-studies-of-dr-elinor-karlson/amp/

What is a realistic virtual earth, - and for genetics especially? Here's a start - http://scott-macleod.blogspot.com/2020/10/google-earth-what-is-realistic-virtual.html - and here's a related #HashTag - https://twitter.com/HarbinBook/status/1383620373690810374?s=19 - with other #RealisticVirtualEarthForGenetics' Tweets throughout Twitter and my blog. 

If you might be in the Boston or Worcester areas before or after this weekend and would like to meet for a coffee and to talk, please let's get together. 

Best wishes, Scott

-- 

- Scott GK MacLeod  

Founder, President, CEO & Professor

World Univ & Sch (WUaS) - PO Box 442, Canyon, CA 94516 

1) non-profit World University and School - http://worlduniversityandschool.org  

2) for profit general stock company WUaS Corporation in CA - http://worlduniversityandschool.org/AcademicPress.html

(o) 415 480 4577 - sgkmacleod@worlduniversiryandschool.org 

(m) 412 478 0116 - sgkmacleod@gmail.com 

World Univ & Sch Innovation Research -  scottmacleod.com 

- CC World University and School - like CC Wikipedia with best STEM-centric CC OpenCourseWare - incorporated as a nonprofit university and school in California, and is a U.S. 501 (c) (3) tax-exempt educational organization. 

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Scott MacLeod <sgkmacleod@worlduniversityandschool.org>

Sun, Apr 18, 7:03 PM

to Elinor.Karlsson

Dear Elinor, 

I just filled out this survey, and also have some questions about a Drosophila genetics' project I'm interested in. I'm interested in this particular project with regards to developing CC-4 MIT OCW-centric wiki World University and School and also regarding an Actual-Virtual realistic virtual earth for genetics (see below) - and for longevity, and aging reversal, questions especially. I think your knowledge could help shape this further in great and fascinating ways. 

Below are the questions I asked in your January talk, as well as my responses to the survey questions I just finished. 

Am exploring the idea of heading back to Cuttyhunk island, Massachusetts (where my family has a home), from the SF Bay Area, from around June 28th until August 4th or 5th or so, and wonder if you might like to meet for a cup of coffee sometime? I'd like to see the Worcester Art Museum as well as the Ecotarium (if they will be open during the coronavirus pandemic), and wonder if one of these places could even be good to meet at?

Thank you for your interesting Broad Institute talk in January - https://youtu.be/YKjYFydrje0. 

Sincerely, Scott

PS This is the idea in the big picture -

Where to begin with Vast #Wiki #WUaSData project of 1 #RealisticVirtualEarth for EVERYTHING since 4.6 billion yrs ago & at cell & atomic levels too & as #RealisticVirtualEarthForGenetics? #BeginAtTheBeginning? https://www.goodreads.com/quotes/6305-begin-at-the-beginning-the-king-said-very-gravely-and Is this #StreetView #TimeSlider #TensorFlowAI?

https://twitter.com/scottmacleod/status/1383620176629751816?s=19

https://twitter.com/WorldUnivAndSch/status/1383619885171761158?s=19

https://twitter.com/WUaSPress/status/1383620420025257991?s=20

https://twitter.com/scottmacleod/status/1383620176629751816?s=20

https://twitter.com/HarbinBook/status/1383620373690810374?s=20

https://twitter.com/TheOpenBand/status/1383620317059244037?s=19

Written responses to survey:

1

World University and School's President, Founder, CEO, a Professor here (where WUaS is like CC-4 MIT OCW in 4 languages with Wikipedia in 300 languages))

5

Interested in Genetics at MIT OCW-centric WIKI World University and School, and potentially regarding planning for genetics for all 7.8 billion people (eg in collaborating with WikiTree), and for other species, and individuals too, for ex., in a single #RealisticVirtualEarthForGenetics - https://twitter.com/hashtag/RealisticVirtualEarthForGenetics?src=hashtag_click - and also regarding questions of Actual-Virtual (#ActualVirtual) developments, and for Digital Species, and regarding longevity and aging reversal questions too, eg see - https://twitter.com/WorldUnivAndSch/status/1376645462556438529?s=20 ~

9

Broad question: How could we best explore these phenotype questions about genomics and adaptations (hibernation) in a realistic virtual earth (think Google Street View with time slider, Maps, Earth, TensorFlow AI and Samsung Neons' artificial humans and artificial species' individuals - even with a film-to-3D App) at the cellular and molecular levels too? I'm thinking in terms of a  RealisticVirtualEarthForEvolution and RealisticVirtualEarthForGenetics in particular (see below). Thank you.

https://twitter.com/hashtag/RealisticVirtualEarthForEvolution?src=hashtag_click

https://twitter.com/hashtag/RealisticVirtualEarthForGenetics?src=hashtag_click

Scott (sgkmacleod@worlduniversityandschool.org)

10

Longevity, aging reversal with genetic therapies, Actual-Virtual Drosophila melanogaster research in these regards, new tools for genetic virtual research, perhaps emerging from a realistic virtual earth for CRISPR - https://twitter.com/hashtag/RealisticVirtualEarthForCRISPR?src=hashtag_click - into a single realistic virtual earth for evolutionary biology - https://twitter.com/hashtag/RealisticVirtualEarthForEvolutionaryBiology?src=hashtag_click - eg - https://twitter.com/HarbinBook/status/1370926854257876995?s=20 (where Actual-Virtual Harbin Hot Springs is also my long term ethnographic field site, and at the cellular and molecular levels too). Thank you.

12

Into a realistic virtual earth - thinking Google Street View with TIME SLIDER (re seasons' word), Maps, Earth, TensorFlowAI, Translate - and even realistic avatar bots like Samsung Neons, and even group buildable like Google Monster Mash - https://twitter.com/hashtag/RealisticVirtualEarthForSTEM?src=hashtag_click ? DataPools? How best to plan for #WUaSDataPools FOR #DigitalSpecies like #ActualVirtual #Drosophila flies -  https://twitter.com/DrPinarUstaoglu/status/1374328288894664705 &vav "place,"& coding (javascript, #TensorFlowAI?) in #GoogleStreetView with #TIMESLIDER / Maps / Earth & even #AvatarBotElectronicMedicalRecords?

https://twitter.com/sgkmacleod/status/1379228262249852935?s=20

~ #GrabTheAIcode #GoogleMonsterMash

to co-create your own #ActualVirtual #AvatarBotElectronicMedicalRecords for 7.8 B Peops with #StanfordDukeProjectBaseline #RealisticVirtualEarthForLegoRobotics in #GoogleStreetViewMaps #NextKillerApp like #EmailForBusiness? #MosaicGUIbrowser?

https://twitter.com/WorldUnivAndSch/status/1380909570944462855?s=19

https://scott-macleod.blogspot.com/2021/04/sapphire-lake-evolution-basin-high.html

Questions and text chat from your talk:

Thank you!  

Sophia Wolfe (she/her)       02:16 PM

Is the human reference genome at the human genome project a single genome or an 'average' from all samples collected?

This question has been answered live

Anonymous Attendee       02:21 PM

How much of the genome is conserved across the 240 mammals?

This question has been answered live

Stephanie Lam       02:25 PM

when comparing across diverse mammals, what % of human coding genes are conserved compared to completely new genes of unknown function?

This question has been answered live

Scott GK MacLeod (You)       02:28 PM

How do breeds (the labs) & ‘outbreeds’ (or what you called the cats)) - and humans’ genomes - retain fertility but donkeys mules and donkeys don’t  even in terms of the genetic characterizations, Elinor, that you’re making for Zoonomia? Thank you. Scott (sgkmacleod@worlduniversityandschool.org)

Ms.Borrelli (she/her)       02:31 PM

This presentation is so awesome. I begin teaching my next high school Zoology class on Monday and would love to show the students this presentation. Will the recording be available?

Tom Ulrich       02:45 PM

Thank you so much! Yes, we will post a recording of the talk on our YouTube channel: https://www.youtube.com/user/broadinstitute

Family Healthy Choices       02:31 PM

Is the Powerpoint presentation available to access and download?  Thank you.

Tom Ulrich       02:46 PM

I will ask Elinor and Diane if they’d like to make the slides available. If they do, we’ll post them on our website. Thanks!

Heather Remoff       02:33 PM

Might it be possible for the natural world to shape a gene drive that could be inserted into our genomes via pandemic viral infections?

Tom Ulrich       02:43 PM

Great question! In a sense, the natural world already did that, millions of years ago. Researchers think that somewhere between 5 and 8% of our genome came from ancient viruses.

Anonymous Attendee       02:44 PM

Will this seminar be available online? I find it very inspiring and would love to revisit some of the concepts.

Tom Ulrich       02:47 PM

Thank you so much! Yes, we will post a recording of the talk on our YouTube channel: https://www.youtube.com/user/broadinstitute

Hamid Gaikani       02:46 PM

Hi. Is there any position in the genome that is 100% conserved? I mean, any mutation would cause death.

Scott GK MacLeod (You)       02:51 PM

Broad question: How could we best explore these phenotype questions about genomics and adaptations (hibernation) in a realistic virtual earth (think Google Street View with time slider, Maps, Earth, TensorFlow AI and Samsung Neons' artificial humans and artificial species' individuals - even with a film-to-3D App) at the cellular and molecular levels too? I'm thinking in terms of a  RealisticVirtualEarthForEvolution and RealisticVirtualEarthForGenetics in particular (see below). Thank you.

https://twitter.com/hashtag/RealisticVirtualEarthForEvolution?src=hashtag_click

https://twitter.com/hashtag/RealisticVirtualEarthForGenetics?src=hashtag_click

Scott (sgkmacleod@worlduniversityandschool.org)

Mammals & genomics. Diane Genereux and I distill it to (comparative) essentials in

@broadinstitute

 public lecture “Clarity from comparison: How other animals' genomes illuminate our own.” Sadly, few

@ZoonomiaProject

 species survived the #2021MMM #carnage https://youtu.be/YKjYFydrje0

https://twitter.com/eenork/status/1374216872384724993?s=20

Thank you, Elinor, 

All the best, Scott

 University of Massachusetts Medical School

368 Plantation Street, Sherman Center, AS4.1065

Worcester MA 01605

Email Elinor.Karlsson@umassmed.edu

https://profiles.umassmed.edu/display/11661398

*

Scott MacLeod <sgkmacleod@worlduniversityandschool.org>

Sun, Apr 18, 8:04 PM

to gchurch, Elinor.Karlsson

Elinor, (and George), 

Greetings again, and I hope this finds you both very well.

As a follow up (having filled out the Broad Institute's survey form today with questions per your edifying January Broad talk), and regarding a Drosophila fly longevity conversation: 

In what ways could we double the lifespans of actual individual Drosophila flies in the jar - 

CRISPR for reversion! Exciting times 😇 #Drosophilapic.twitter.com/8mVYNpQ7an

— Pinar Ustaoglu (@DrPinarUstaoglu) March 23, 2021

https://twitter.com/DrPinarUstaoglu/status/1374328288894664705?s=19

Focus on lifespan #Longevity with #AgingReversal? ~ #Drosophila ~ https://t.co/kQi6I68nas#WUaSLongevity#WUaSagingReversal in a #RealisticVirtualEarthForCRISPR (think #GoogleStreetView with #TimeSlider with #AI at cell & molecular levels with #DigitalSpecies@WorldUnivAndSch) https://t.co/YtgrYfF9Uc

— WorldUnivandSch (@WorldUnivAndSch) March 31, 2021

(https://twitter.com/WorldUnivAndSch/status/1377070127976312838?s=19) ?

Could we double their lifespans via a spray or food into this jar (of a genetic drug researchers might develop) even?

In what ways could we map an individual fly's genome at a certain point in time - to A G C Ts ? And with machine learning, in what ways could we map this genome out in new AGCTs as an extended lifespan, say to 180 days (if 40-50 days or 90 days is the outer limit of a Drosophila fly's life span) - so virtually and digitally? (These Actual-Virtual developments as conversation, I'm particularly interested in). 

And if gene function declines as an organism ages - per Harvard MIT Professor of Genetics' George Church - https://youtu.be/bnCEIPQFNnk - what does this look like in A G C & Ts at different time points?

Further, if one could develop a film-to-3D App for 'everything,' and here for Drosophila flies, in what ways could one transpose these flies in this jar into 3D Drosophila flies - think Google Poly, a library of virtual objects (which is closing soon) - and in a realistic virtual earth for species https://twitter.com/TheOpenBand/status/1367587550274015232?s=19 (and at the cellular and molecular levels too)? 

Is it possible to tag Drosophila flies individually, like in this jar, and sequence their genomes at different time points? 

Thank you,

Scott

'genes' label in daily blog - https://scott-macleod.blogspot.com/search/label/genes?m=0

(See 'longevity' label too)

 PS

In what ways WOULD it be possible to build a realistic virtual earth for species as new genetic tools that would allow us to make hybrid organisms like this genetically engineered Axolotl-Bird hybrid -

https://scott-macleod.blogspot.com/2021/02/chamaenerion-angustifolium.html?m=0 ? 

Thanks,

Scott

- CC-4 MIT OCW-centric wiki worlduniversityandschool.org

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https://en.wikipedia.org/wiki/Ellipsoptera_puritana

https://en.wikipedia.org/wiki/Cicindela_puritana

https://commons.wikimedia.org/wiki/Category:Cicindela_puritana

https://no.wikipedia.org/wiki/Ellipsoptera

https://commons.wikimedia.org/wiki/Category:Ellipsoptera_puritana

https://en.wikipedia.org/wiki/Habroscelimorpha_dorsalis_dorsalis

https://www.ctpost.com/news/slideshow/Connecticut-s-endangered-species-96203.php

...