Greenland shark: 'The bridge between molecular and cellular worlds is being built. It’s a whole new world …'

Dear Aubrey (Weigel), Tzumin (Lee), Ewan (Birney), Peter (Norvig), George (Church), Jukka-Pekka (Onnela), Elinor (Karlsson), Robert (Harrington MD), Ed (Smyth) All,  

Greetings from the SF Bay Area! I'm writing to you as President of, and Professor at, (impoverished) World University & School (which is like CC-4 MIT OCW in 4 languages, with Wikipedia in 300 languages, planed in ~200 countries for free-to-students' online Bachelor, PhD, Law, MD, and IB high school degrees, and as wiki schools in all 7,139 living languages) about a realistic virtual earth for genetics, and in a single realistic virtual earth for everything; think Google Street View with Time Slider, Maps, Earth, TensorFlowAI, Translate, and with realistic avatar bots and their electronic medical records (even for planning for the precision of tele-robotic surgery, in a realistic virtual earth for surgery

 - https://twitter.com/TheOpenBand/status/1304904656259182592?s=20), for all 7.8 billion people, and their genomes, and at the molecular and cellular levels too - thanks Ewan for this following seminal Tweet (which is music to my eyes:),  

In these regards, thanks also Ewan for re-Tweeting Aubrey's great 2020 post with - 

"The bridge between molecular and cellular worlds is being built. It’s a whole new world …"

And thanks, Aubrey, for liking these 6 Tweets of World Univ & Sch's recently - 

! @avweigel
 What about bridges BETW molecular (eg genes) & the #Phenotypes of individuals (in #GoogleStreetView w #TimeSlider) & #species, & BETW the cellular world & #StreetView level too, with #MachineLearning in #RealisticVirtualEarthforGenetics in 1 #RealisticVirtualEarth ?

! @avweigel What about bridges BETW molecular (eg genes) & the #Phenotypes of individuals (in #GoogleStreetView w #TimeSlider) & #species, & BETW the cellular world & #StreetView level too, with #MachineLearning in #RealisticVirtualEarthforGenetics in 1 #RealisticVirtualEarth ? https://t.co/a6opsIYC4G

— WorldUnivandSch (@WorldUnivAndSch) October 8, 2021

 

 https://twitter.com/TheOpenBand/status/1446548906179891205

Languages - World University:

While I've blogged about these your Tweets (and below) and much more here, yesterday - http://scott-macleod.blogspot.com/2021/10/bowhead-whale-aging-reversal.html (in my daily blog), and with much more including, I'm interested in inquiring about and strategizing how these A.I. I.T. developments relating to bridging the molecular with the cellular and the Street View 'worlds' might be designed for 1) aging reversal genetic engineering drug therapies' research, as well as for 2) longevity research, among other approaches to building out a single realistic virtual earth for genetics and evolutionary biology especially. 

And thanks, Tzumin, for your fascinating digital 3D modeling of fly brains (https://www.janelia.org/lab/lee-tzumin-lab), and George, for your great CalTech Allen Institute Hindsight 2020 presentations earlier this year.  

Thanks, too, Tzumin, for your answer to my questions in the CalTech presentation, and related to this fascinating Stanford Medicine Drug conference presentation, in April; here are some of the questions I asked in the CalTech presentation - 

So I'm writing further regarding connecting all the dots, and with a focus on longevity and aging reversal, both actually and virtually, physically and digitally (an ongoing focus of mine in seeking to facilitate a single realistic virtual earth for everything). I'm wondering too, for example, about possibly exploring some of these questions with drosophila flies in a jar (in the laboratory), such as this -  

CRISPR for reversion! Exciting times  #Drosophila

https://twitter.com/DrPinarUstaoglu/status/1374328288894664705?s=20
AND re-Tweeted - 

Focus on lifespan #Longevity with #AgingReversal? ~ #Drosophila ~ https://scott-macleod.blogspot.com/2021/03/wild-drosophila-melanogaster-fruit-fly.html #WUaSLongevity #WUaSagingReversal in a #RealisticVirtualEarthForCRISPR (think #GoogleStreetView with #TimeSlider with #AI at cell & molecular levels with #DigitalSpecies
@WorldUnivAndSch)

Focus on lifespan #Longevity with #AgingReversal? ~ #Drosophila ~ https://t.co/kQi6I68nas#WUaSLongevity#WUaSagingReversal in a #RealisticVirtualEarthForCRISPR (think #GoogleStreetView with #TimeSlider with #AI at cell & molecular levels with #DigitalSpecies@WorldUnivAndSch) https://t.co/YtgrYfF9Uc

— WorldUnivandSch (@WorldUnivAndSch) March 31, 2021

https://twitter.com/WorldUnivAndSch/status/1377070127976312838?s=20

(with more here - https://scott-macleod.blogspot.com/2021/03/wild-drosophila-melanogaster-fruit-fly.html) 

Stanford and Google's Tom Dean's contributions to the Connectome project focusing on fly brains are relevant here, having heard him talk at Stanford Medicine Grand Rounds, I think, about this some years ago - https://scott-macleod.blogspot.com/2017/04/red-rainbowfish-mit-bachelors-degree-in.html. In what ways could, Aubrey, with you perhaps as Project Scientist, and Tzumin with your amazing modeling of fly brains, could we all develop Actual-Virtual, Physical-Digital fly brain research, further - even with a Film-to-3D Application (at the cellular and molecular levels too) - in creating a single realistic virtual earth? And how could we focus this also on aging reversal as well as on longevity questions. A realistic virtual earth for digital species and individuals' phenotypes, and genetics, would create an amazing array of new genetic tools (way beyond CRISPR CaS9, I think). Peter, might we explore this in the Google (Street View with time slider) ecosystem? And Elinor, might we also apply these developments and tools to mammals? And George, could you please, in focusing, with your amazing knowledge, the coding of aging reversal genetic engineering tools, perhaps in conversation with Peter, as well as other Googlers? 

So, further, and in submitting an abstract for an upcoming Harvard "Smartphones, Wearables, and Health" Symposium, I'm interested in developing the information technology infrastructure for brain research, and regarding generating data, for my actual-virtual, physical digital Harbin Hot Springs' Ethnographic project, which would include brain research from the Harbin warm pool, in situ, into even avatar bot electronic medical records via wireless web streaming. This would include modeling people's phenotypes as well, which is a key focus of Harvard Professor Jukka-Pekka Onnela (see below, and "JP Onnela on Smartphone-Based Digital Phenotyping and Beiwe Research Platform (TIPS 2017)" 

- https://vimeo.com/252384345 ). In what ways could actual-virtual research and modeling of fly brains parallel and come into conversation with actual-virtual research and modeling of human brains - and in a single realistic virtual earth not only for genetics, but also for brain science? You'll find my abstract about this here - https://scott-macleod.blogspot.com/2021/10/iceland-catshark-fettes-college.html.

So thanks Jukke-Pekka (whom I met at Stanford Medicine around 2017), for this Harvard Medical School "Smartphones, Wearables, and Health" data science conference - 

"Our 3rd annual Data Science symposium will take place in Boston on Nov 5 with the theme "Smartphones, Wearables, and Health". Speakers from the NIH, academia, and industry. Registration is now open! Abstract submission deadline Oct 5.
https://projects.iq.harvard.edu/cnoc-symposium "

Our 3rd annual Data Science symposium will take place in Boston on Nov 5 with the theme "Smartphones, Wearables, and Health". Speakers from the NIH, academia, and industry. Registration is now open! Abstract submission deadline Oct 5.https://t.co/bdBelbQutBpic.twitter.com/WvGDgbQIr6

— Jukka-Pekka Onnela (@jponnela) August 27, 2021

https://twitter.com/jponnela/status/1431351496013238281?s=20
which abstract submission I posted here - 

Aubrey, Tzumin, Ewan, Peter, George, Jukka-Pekka, Elinor, Jim, Larry, Dick, All, how might we explore some of these questions further? And would you be interested, Aubrey, in becoming the Project Scientist organizer, for some of this too, if we could begin to grow such a single realistic universe for aging reversal, genetics, for species, evolutionary biology, STEM science, and everything? And might I even begin to touch on some of these new IT developments and emergences in my planned Harvard "Smartphones, Wearables, and Health" on November 5th?  

Looking forward to communicating further about this. Thank you.

All the best, Scott

some related recent Tweets ... 

1

At scale #Genomics? w "The bridge betw #molecular & #cellular worlds is being built. It’s a whole new world " @ewanbirney https://www.genome.gov/player/dCTxYJpilwQ/PL1ay9ko4A8sk0o9O-YhseFHzbU2I2HQQp in 1 #RealisticVirtualEarthForGenetics >http://scott-macleod.blogspot.com/2021/10/bowhead-whale-aging-reversal.html w #FilmTo3D App & #TextInTheSidebar of #StreetView for new publishing?

2

! @ewanbirney What about bridges BETW molecular (eg genes) & the #Phenotypes of individuals (in #GoogleStreetView w #TimeSlider) & #species, & BETW the cellular world & #StreetView level too, with #MachineLearning in #RealisticVirtualEarthforGenetics in 1 #RealisticVirtualEarth ?

! @ewanbirney What about bridges BETW molecular (eg genes) & the #Phenotypes of individuals (in #GoogleStreetView w #TimeSlider) & #species, & BETW the cellular world & #StreetView level too, with #MachineLearning in #RealisticVirtualEarthforGenetics in 1 #RealisticVirtualEarth ? https://t.co/pYe77GFEif

— WorldUnivandSch (@WorldUnivAndSch) October 8, 2021

https://twitter.com/WorldUnivAndSch/status/1446542987115171840?s=20

Conversation in Twitter
https://twitter.com/scottmacleod/status/1446545850541359109

3
! @avweigel What about bridges BETW molecular (eg genes) & the #Phenotypes of individuals (in #GoogleStreetView w #TimeSlider) & #species, & BETW the cellular world & #StreetView level too, with #MachineLearning in #RealisticVirtualEarthforGenetics in 1 #RealisticVirtualEarth ?

! @avweigel What about bridges BETW molecular (eg genes) & the #Phenotypes of individuals (in #GoogleStreetView w #TimeSlider) & #species, & BETW the cellular world & #StreetView level too, with #MachineLearning in #RealisticVirtualEarthforGenetics in 1 #RealisticVirtualEarth ? https://t.co/a6opsIYC4G

— WorldUnivandSch (@WorldUnivAndSch) October 8, 2021

https://twitter.com/WorldUnivAndSch/status/1446543264421593088?s=20

4
We are proud to share our work on segmenting up to 35 organelles & macromolecular structures in whole cell isotropic FIB-SEM at 4 & 8nm resolution https://biorxiv.org/content/10.1101/2020.11.14.382143v1 1/12

(longevity, and even re aging reversal ... 

Icelandic mussel named Ming (507 years)

Greenland shark (392 years)

Greenland whale (211 years)

Jeanne Calment (122 years) )