Steller sea lion: 4 main Tweets today about this gene editing Debate yesterday: Vote, comment & watch: "Use Gene Editing to Make Better Babies" * 4 Re #GermlineEditing & #WUaSGreatDebate check out #ForTheMotion & #AgainstTheMotion here https://intelligencesquaredus.org/debates/use-gene-editing-make-better-babies & Video will be up for 7 days > 1 #PhysicalDigital #RealisticVirtualEarthForGenetics @WorldUnivAndSch Connect w/ #StanfordMinePi cryptocurrency https://minepi.com/sgkmac? * * Surfing in February in Santa Cruz, California, not too far from the University, (with UCSC's former banana slug mascot, now sea lion , 8 yrs ago today. With an invitation to @WorldUnivAndSch'S open Monthly Business Meeting Sa 9a PT http://scott-macleod.blogspot.com/2022/02/otter-sea-enhydra-lutris.html?m=0 ~

?#GermlineEditing in 200 countries for heritable genetic diseases: https://t.co/aYtbaQcuOI (FDA approved, equitable)https://t.co/Yr8gN5VIJl in 1 #PhysicalDigital#RealisticVirtualEarth#RealisticVirtualEarthForGenetics w 7.9B #AvatarBotElectronicMedicalRecords@WorldUnivAndSch? https://t.co/IeVjTVHuBn

— WUaSPress (@WUaSPress) February 18, 2022

• The use of gene editing allows for couples to have children when they might otherwise have that option unavailable for them. It also allows for less to be left to chance during the pregnancy.
• Gene editing will allow for babies to be born with reduced or eliminated chances of inheriting and passing on genes linked to diseases. We have a moral imperative to use technology that will improve the quality of life.
• It is only a matter of time before gene editing becomes a widespread technology, potentially used by competitors and rivals on the international stage. If we have the technology, we should use it to our advantage to remain competitive.

Against the Motion - 

• The use of gene editing to create "better" outcomes in children will inherently create social stratification based on any gene editing, likely reflecting existing socioeconomic status. Additionally, the term 'better' is arbitrary and potentially short-sighted and dangerous.
• Currently, there exist reasonable alternatives to gene editing for every condition for which gene editing can be used. 
• The technology is still developing, and the long-term effects of any gene-editing could be potentially dangerous with consequences echoing throughout the gene environment. 

https://intelligencesquaredus.org/debates/use-gene-editing-make-better-babies

* * 

Eastern newt: Check out this debate this afternoon with Harvard Medical School's George Church & 3 others at 2 PT on gene editing - "For what diseases? ... FDA approvable, and equitably accessible ..." - with relevance @WorldUnivAndSch & a #RealisticVirtualEarthForGenetics for molecular engineering

*
Check out this debate this afternoon with Harvard Medical School's George Church & 3 others at 2 PT on gene editing - "For what diseases? ... FDA approvable, and equitably accessible ..." -

Thur Feb 17th : You can vote & comment. For what diseases (present & future) is genetic medicine a good option, FDA approvable, and equitably accessible -- $2/dose or free? https://t.co/bHN1QpeeEh

— george church (@geochurch) February 16, 2022

https://twitter.com/geochurch/status/1494080415895896066 with relevance @WorldUnivAndSch & a #RealisticVirtualEarthForGenetics for molecular engineering 

Check out this debate this afternoon with HMS's George Church & 3 others at 2 PT on gene editing - "For what disease~FDA approvable, and equitably accessible" -https://t.co/yDSLz5Vc3j with relevance @WorldUnivAndSch & a #RealisticVirtualEarthForGenetics for molecular engineering

— WorldUnivandSch (@WorldUnivAndSch) February 17, 2022

https://twitter.com/WorldUnivAndSch/status/1494341090001883136

https://twitter.com/scottmacleod/status/1494342662635220995?s=20&t=9wUZE2I_rZ2o9N52I6Zyqw

https://twitter.com/HarbinBook/status/1494343166744432650?s=20&t=9wUZE2I_rZ2o9N52I6Zyqw

https://twitter.com/TheOpenBand/status/1494342913022566412?s=20&t=9wUZE2I_rZ2o9N52I6Zyqw

https://twitter.com/sgkmacleod/status/1494342778393743368?s=20&t=9wUZE2I_rZ2o9N52I6Zyqw

https://twitter.com/WUaSPress/status/1494342456036376579?s=20&t=9wUZE2I_rZ2o9N52I6Zyqw

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What Is Gene Therapy? How Does It Work?

https://www.fda.gov/consumers/consumer-updates/what-gene-therapy-how-does-it-work

FDA allows marketing of first direct-to-consumer tests that provide genetic risk information for certain conditions

https://www.fda.gov/news-events/press-announcements/fda-allows-marketing-first-direct-consumer-tests-provide-genetic-risk-information-certain-conditions

WARNING LETTER

Haloderm, Inc.

MARCS-CMS 608852 — OCTOBER 06, 2020

https://www.fda.gov/inspections-compliance-enforcement-and-criminal-investigations/warning-letters/haloderm-inc-608852-10062020

Human Gene Therapy for Rare Diseases

Guidance for Industry

https://www.fda.gov/media/113807/download

*

What Is Gene Therapy? How Does It Work? https://www.fda.gov/consumers/consumer-updates/what-gene-therapy-how-does-it-work FDA allows marketing of first direct-to-consumer tests ... https://www.fda.gov/news-events/press-announcements/fda-allows-marketing-first-direct-consumer-tests-provide-genetic-risk-information-certain-conditions Haloderm, Inc. WARNING LETTER https://www.fda.gov/inspections-compliance-enforcement-and-criminal-investigations/warning-letters/haloderm-inc-608852-10062020 Human Gene Therapy for Rare DiseasesGuidance for Industry ~

What Is Gene Therapy? How Does It Work?https://t.co/lbzTVGgfo6
FDA allows marketing of first direct-to-consumer testshttps://t.co/eVsb6CyiKU
Haloderm, Inc. WARNING LETTERhttps://t.co/qzCTC0hWPM
Human Gene Therapy for Rare Diseases
Guidance for Industryhttps://t.co/UNWLGvCl8P~

— Scott_GK_MacLeod_WUaS_worlduniversityandschool.org (@scottmacleod) February 17, 2022

https://twitter.com/scottmacleod/status/1494350489059676160

Hi Ed, there's a debate this afternoon with HMS's George Church & 3 others at 2 PT on gene editing - "You can vote & comment.   For what diseases (present & future) is genetic medicine a good option, FDA approvable, and equitably accessible" - https://twitter.com/geochurch/status/1494080415895896066 with relevance @WorldUnivAndSch & #RealisticVirtualEarthForGenetics for molecular engineering (https://twitter.com/WorldUnivAndSch/status/1494341090001883136) Any interest? I'm attending (go to an academic debate together? We haven't done this much :)

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Will genetic engineering drugs be different, in an unique category, from say new antibiotics? I selected the 'undecided' option when registering - https://intelligencesquaredus.org/debates/use-gene-editing-make-better-babies - about this 'motion'"Use Gene Editing to Make Better Babies" ... you? You'd register with this link ... 

Hi Ma, 

* * 

Some after this 'gene editing' debate knowledge sharing - 

* * *

MIT Tech Review: "In this debate, George Church just called mRNA vaccines gene therapy.  This is sufficient to be banned from further speech"

Antonio Regalado

@antonioregalado

Feb 17

In this debate, George Church just called mRNA vaccines gene therapy.  This is sufficient to be banned from further speech.

In this debate, George Church just called mRNA vaccines gene therapy. This is sufficient to be banned from further speech. https://t.co/K8mDAMm7EN

— Antonio Regalado (@antonioregalado) February 17, 2022

https://twitter.com/antonioregalado/status/1494438954904530947

*

george church

@geochurch

Feb 19

Replying to 

@antonioregalado

I said "AstraZeneca & Sputnik Covid19 vaccines are Adenoviral capsid delivery of DNA"  (& yes, btw, synthetic mRNA in LNPs can also be a form of gene therapy)

I said "AstraZeneca & Sputnik Covid19 vaccines are Adenoviral capsid delivery of DNA" (& yes, btw, synthetic mRNA in LNPs can also be a form of gene therapy) https://t.co/PRR3qJe3JI

— george church (@geochurch) February 19, 2022

https://twitter.com/geochurch/status/1495002233045405699

* 

george church

@geochurch

Feb 19

Replying to 

@antonioregalado

"these mRNA vaccines, which have been developed and approved within a few months, signify a breakthrough in the field of gene therapy"

"these mRNA vaccines, which have been developed and approved within a few months, signify a breakthrough in the field of gene therapy" https://t.co/5svDfKi6m8

— george church (@geochurch) February 19, 2022

https://twitter.com/geochurch/status/1495006382092951555

* * 

Antonio Regalado

@antonioregalado

Feb 18

Replying to 

@dshahh

good example. if gene therapy refers to the ends (change in nuclear DNA), not the means, could we say radiation therapy qualifies?

good example. if gene therapy refers to the ends (change in nuclear DNA), not the means, could we say radiation therapy qualifies?

— Antonio Regalado (@antonioregalado) February 18, 2022

https://twitter.com/antonioregalado/status/1494766715456167941

*

george church @geochurch Feb 19

Replying to 

@antonioregalado and @dshahh

Gene therapies consist of genes (just as mAb Tx consists of antibodies, & protein Tx consist of proteins). Genes can be RNA or DNA (e.g. in viral delivery of Tx & can interconvert via RT & RNAP).

Gene therapies consist of genes (just as mAb Tx consists of antibodies, & protein Tx consist of proteins). Genes can be RNA or DNA (e.g. in viral delivery of Tx & can interconvert via RT & RNAP).

— george church (@geochurch) February 19, 2022

https://twitter.com/geochurch/status/1495027566817812483?s=20&t=1Ag-3plY-O4lAu_Cx6yt1w