Greetings from MIT OCW-centric wiki World Univ & Sch WUaS. How are you? I hope this email finds you well.
The next MIT OCW-centric - https://ocw.mit.edu/ - wiki World Univ & Sch WUaS News and Q&A meets on Monday June 9, 2025 now again at 10:00 AM Pacific Time, 1:00 PM ET (US & Canada), 5:00 PM GMT, 10:30 PM India Time, 1:00 AM Tu the next day Hong Kong Time (but please check your time converter from any of your 24 time zones to join this open WUaS Monthly Business Meeting) with Zoom URL here too -
Free MIT OCW-centric wiki World Univ & Sch is growing, and growing with #GrowWithGoogleWUaS, for free-to-students' online degrees - Bachelor, PhD, Law, MD IB high school/similar, AA/AS, and Master's - first in English, then in each of all ~200 countries and in their main languages, and see Peter Norvig's INCREDIBLE #ToolifyAIWUaS "Revolutionizing Education with Machine Learning and AI: #WorldUniversityInSchool" - https://www.toolify.ai/ai-news/revolutionizing-education-with-machine-learning-and-ai-2574306.
All the best, abolition-ally, Friendly greetings, Scott
Sunday, June 15, 2025 Book Cliffs, UT and CO: Twitter Geo Church - Absolutely crazy month for progress in the world of genome instability & DNA repair, especially as pertaining to aging
How best @alantomusiak @amplesa @davidsunkong #HTGAAbios @geochurch to dev a 1st #AgingReversalGenetics' course -https://wiki.worlduniversityandschool.org/wiki/Aging_Reversal_Genetics @ #MITOCW-centric wiki @WorldUnivAndSch fr recent papers & in #RealisticVirtualEarthForAgingReversal w #GStreetView #GCellView +w #GTimeSlider?
Absolutely crazy month for progress in the world of genome instability & DNA repair, especially as pertaining to aging. A few of the most exciting papers, a : BBBC https://x.com/alantomusiak/status/1933267665700978795
Excited in #WorldUniversityInSchool #RevolutionizingEducation wtih #MachineLearningAndAIinTeaching @WorldUnivAndSch with #PeterNorvigsResearchAtGoogle - & #WUaScoding for 7.9B people, speakers of 7,159 living languages https://wiki.worlduniversityandschool.org/wiki/Languages with #GrowWithGoogleWUaS ~
Further - And excited to continue to grow free-to-students' and wiki Universitians' MIT OCW-centric wiki #GrowWithGoogleWUaS World Univ & Sch WUaS ... for most of all 7.9 billion people on the planet - https://wiki.worlduniversityandschool.org/wiki/You_at_World_University - potentially to seek to end poverty among All the poor (1 billion people possibly?) and also to extend life and reverse aging with aging reversal and extreme longevity genetic drug therapies emerging FDA approved ...
Dear: World University and School This is to notify you that your Gate product indicated below was successfully renewed. Please note the next expiration date for this product.
* Hi Ed, Ma, Pin, how are you doing? Am in a National Forest with no internet access, tired, resting ... wondering about the divine / the 'God' word in the Desiderata - AND in Yoga, in nontheist Friends /Quakers, among Unitarians, Episcopalians Pin & Buddhists /Buddhism & Catholics, Ed, & Hindus /Hinduism + (Huston Smith's 7 religions in The Religions of Man) AND re Identity questions (social science wise, anthropologically and sociologically way beyond Castells' book "The Power of Identity,' the middle book in his Information Age trilogy) and Re Rosemary Ruether's "Sexism and God-Talk" book about which I wrote my Reed College senior thesis, Native Americans' divinity, all of our African ancestry genetics & re religion & the divine ... And re genetics & say Yoga genetics in the above regards ... especially in our human diversity and increasingly diverse world
How best to #InspireYouNOW & people (eg #NativeAmericans in #LakeCountyCA re #NativeAmericanLanguages) to #WikiTeach & #WikiLearn @ #WikiWUaS ...?
How best to #InspireYouNOW & people (eg #NativeAmericans in #LakeCountyCA re #NativeAmericanLanguages) to #WikiTeach & #WikiLearn @ #WikiWUaS @WorldUnivAndSch in #WorldUniversityInSchool #RevolutionizingEducation w #MachineLearningAndAIinTeaching w #PeterNorvigsResearchAtGoogle?
our being able to photo & #WikiCreateLibraries with #AIandML to a #RealisticVirtualEarthForLibraries all ever in all languages
It's our being able to photo & #WikiCreateLibraries with #AIandML to a #RealisticVirtualEarthForLibraries all ever in all languages in now all countries in world https://wiki.worlduniversityandschool.org/wiki/Library_Resources that is newly revolutionary & create networks of people >#SocInfoTechAndGlobalUniversity book
Institutional Data Initiative @instdin A research center at Harvard working to strengthen society’s connection to knowledge by advancing our access to and understanding of the data that shapes AI. https://www.institutionaldatainitiative.org/
H Zhao, RD Hawkins - arXiv preprint arXiv:2506.09391, 2025
Polite speech poses a fundamental alignment challenge for large language models (LLMs). Humans deploy a rich repertoire of linguistic strategies to balance informational and social goals--from positive approaches that build rapport …
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Agenda item 10
Tuesday, June 10, 2025 Aechmea fasciata: Greetings ... Regarding this Yoga Philosophy Discussion Group here and now, Brainstorming, and re "#YogaGenetics? For performance - higher faster stronger athletics - & #ETHICS?" - http://www.scottmacleod.com/yoganotations.html - and aging reversal genetic drug therapies emerging, and potentially reversing aging for Harbin's current founder Kriya Yogi Harvard alumnus too Ishvara Bob Hartley, potentially also in combination with a chair yoga course in a Harbin Hot Springs' warm pool, how might Angela & Victor possibly come to Harbin to teach a Yoga course in this (Angela has taught many Yoga courses for women at Harbin), - to teach Chair Yoga in warm water (for the inner releasing meditation benefits), and for 90 year olds, especially Ishvara and others, - and as possibly musculoskeletal system genetic drug therapies develop for experimentation and clinical trials and even under hippy HIPAA protocols (George, which copies of genes would you suggest to add back in to 90 year olds, George, for reversal of muscle wasting) ?
Dear George (Church, Harvard Medical School), Yogis Angela (Farmer) & Victor (Van Kooten), Yogi Tom (Hess), Ed (Smyth MD), Byron (Hann MD PhD), All,
Greetings ... Regarding this Yoga Philosophy Discussion Group here and now, Brainstorming, and re "#YogaGenetics? For performance - higher faster stronger athletics - & #ETHICS?" - http://www.scottmacleod.com/yoganotations.html - and aging reversal genetic drug therapies emerging, and potentially reversing aging for Harbin's current founder Kriya Yogi Harvard alumnus too Ishvara Bob Hartley, potentially also in combination with a chair yoga course in a Harbin Hot Springs' warm pool, how might Angela & Victor possibly come to Harbin to teach a Yoga course in this (Angela has taught many Yoga courses for women at Harbin), - to teach Chair Yoga in warm water (for the inner releasing meditation benefits), and for 90 year olds, especially Ishvara and others, - and as possibly musculoskeletal system genetic drug therapies develop for experimentation and clinical trials and even under hippy HIPAA protocols (George, which copies of genes would you suggest to add back in to 90 year olds, George, for reversal of muscle wasting) ?
In these regards, from this blog post - https://scott-macleod.blogspot.com/2025/03/marble-mountain-wilderness-ca.html - I "wonder how such possible Yoga asana genetic drug therapies emerging might work with even Chair Yoga for 105 year olds (with their declining 'gene function' and see - Harvard and MIT Professor of Genetics' George Church's 60 Minutes' 66 seconds video -
"How soon could humans reverse the aging process with genetic engineering?" (2019) https://youtu.be/bnCEIPQFNnk"
keeping an eye on the crypto space recently? Elizabeth Stark Crypto TwitterDM & MIT OCW-centric wiki World Univ & Sch & Stanford Mine Pi partnering email June 2025 & US Senator and former Harvard Law Professor Elizabeth Warren,
Dear Elizabeth, US Senator and former Harvard Law Professor Elizabeth Warren,
Thanks for your Twitter Direct Message DM to @sgkmacleod below.
In reply -
Hi Elizabeth Stark (@stackness_), (@SenWarren) MIT OCW-centric wiki @WorldUnivAndSch @WUaSPress ... has a partnering email with Stanford Mine Pi cryptocurrency - https://minepi.com/sgkmac - seeks to code for most of all 7.9 billion people on the planet to create a main single worldwide cryptocurrency and to end poverty worldwide via a new kind of UBI experiment. Thanks, @sgkmacleod @scottmacleod
big fan of the internet. like building things. ceo/founder @lightning labs, fellow @coincenter . taught @stanford + @yalelawtech . #bitcoin Brooklyn, NYJoined January 2012
Hey! Hope you’re having a great and productive day.
Have you been keeping an eye on the crypto space recently? There’s been some really exciting momentum and fresh opportunities popping up I think you might find it pretty interesting.
If you’re open to it, I’d love to share a few quick insights that could actually be valuable for you. No pressure at all just figured it might be worth a quick chat.
Looking forward to hearing from you.
And expanded set of Tweets -
Elizabeth (@stackness_), (@SenWarren) #MITOCW-centric wiki @WorldUnivAndSch @WUaSPress has a partnering email from #StanfordMinePicryptocurrency free money daily - https://minepi.com/sgkmac& will code for most of all 7.9 billion people on planet from https://wiki.worlduniversityandschool.org/wiki/You_at_World_University to create a main single worldwide cryptocurrency and to end poverty worldwide via a new kind of UBI experiment. Thanks, @sgkmacleod @scottmacleod
Society, Information Technology, and the Global University (2025, forthcoming @ WUaSPress )
>#SocInfoTechAndGlobalUniversity book
It's our being able to photo & #WikiCreateLibraries with #AIandML to a #RealisticVirtualEarthForLibraries all ever in all languages in now all countries in world https://wiki.worlduniversityandschool.org/wiki/Library_Resources that is newly revolutionary & create networks of people >#SocInfoTechAndGlobalUniversity book
Institutional Data Initiative @instdin A research center at Harvard working to strengthen society’s connection to knowledge by advancing our access to and understanding of the data that shapes AI. https://www.institutionaldatainitiative.org/
Google DeepMind Cyclone Prediction & How to grow a #RealisticVirtualHarbin in 1 iterating #RealisticVirtualEarth @demishassabis #PredictTheWeather of #NeuralCascadesOfPleasure re #TheStudyOfBliss #EnjoymentInLearning #ExploringBliss #VirtualHarbinHotSprings?
Accurate weather prediction is extremely important for keeping people safe, particularly when it comes to dangerous cyclones. Exciting to see this new initiative from @GoogleDeepMind& @GoogleResearch in partnership with @NWSNHC. https://t.co/egvm9EBJhf
Google DeepMind @GoogleDeepMind We’re using AI to improve cyclone prediction.
Introducing Weather Lab: a new interactive platform developed with @GoogleResearch,
hosting our experimental AI weather model which can predict a cyclone’s track, intensity, size and structure.
Here’s how it works.
We’re using AI to improve cyclone prediction. 🌀
Introducing Weather Lab: a new interactive platform developed with @GoogleResearch, hosting our experimental AI weather model which can predict a cyclone’s track, intensity, size and structure.
How will a #RealisticVirtualEarthForClinicalTrials in 1 iterating #RealisticVirtualEarth help potentially speed up #ClinicalTrials w #MLandAIWUaS & #LLMs @WorldUnivAndSch w #KPclinicalTrials in 8 US states - & in all ~200 countries & in main languages, & with #PacketsInTheMail ?
and could WUaS with KP do some clinical trials on aging reversal and extreme longevity genetic drug therapies when they're to that stage & re #YogaGenetics, eg higher, faster, stronger, more supple - http://www.scottmacleod.com/yoganotations.html - especially?
AI and machine learning are revolutionizing clinical trials by optimizing various stages, from design and recruitment to data analysis and patient monitoring. AI-powered tools can accelerate the process, reduce costs, and potentially improve patient outcomes by leveraging large datasets, predictive analytics, and automation.
Here's how AI and ML are transforming clinical trials:
AI algorithms can analyze vast amounts of data to optimize trial protocols, including patient selection criteria, treatment plans, and data collection methods, leading to more efficient and effective trials.
Machine learning models can simulate trial outcomes, helping researchers identify the most promising protocols and potentially predict patient responses.
AI algorithms can quickly match patients with suitable trials based on their medical history and characteristics, speeding up recruitment and improving the diversity of trial populations.
AI can automate data analysis, identify patterns and correlations in large datasets, and generate insights that might be missed by traditional methods.
Wearable devices and sensors, combined with AI, can enable real-time monitoring of patient data, allowing for early detection of adverse events and timely interventions.
A patient recruitment tool developed by a company (not specified in the search results) in partnership with OpenAI, using AI to streamline the patient recruitment process.
In conclusion, AI and ML are transforming clinical trials by enhancing efficiency, improving data analysis, and potentially leading to better patient outcomes. While challenges remain, the potential benefits of integrating AI into clinical research are significant, paving the way for faster and more effective drug development
aging reversal genetic drug therapies in clinical trials ...
Several promising genetic and drug therapies aimed at reversing or slowing aging are currently in clinical trials. These therapies target various aspects of aging, including epigenetic changes, cellular senescence, and molecular pathways related to aging. Some approaches involve gene therapy to restore youthful cellular function, while others focus on small molecule drugs that can reprogram cells or modulate specific biological pathways.
This approach aims to reverse age-related epigenetic changes, which are modifications to DNA that affect gene expression without altering the underlying DNA sequence. Clinical trials are exploring the use of Yamanaka factors (or a subset) to partially reprogram cells to a younger state, with promising results in preclinical models according to ScienceDirect.com and the National Institutes of Health (NIH).
These drugs target and eliminate senescent cells, which accumulate with age and contribute to inflammation and tissue dysfunction. Senolytics like ABT-263 have shown promise in accelerating wound healing and potentially treating age-related diseases according to SciTechDaily.
NAD+ levels decline with age, and supplementation with NAD+ precursors like nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN) has shown potential in preclinical models to improve cellular function and healthspan. Some clinical trials are exploring the use of these compounds in humans.
mTOR is a protein kinase involved in cell growth and metabolism. Inhibition of mTOR with drugs like rapamycin has shown life-extending effects in animal models, and some clinical trials are investigating its potential in humans.
Telomeres shorten with age, and this shortening is linked to cellular senescence and aging. Some therapies aim to activate telomerase, the enzyme that lengthens telomeres, to potentially reverse age-related changes.
Clinical Trials and Research:
Harvard Medical School:
Researchers are developing a chemical approach to reverse aging by reprogramming cells to a younger state, previously only achievable with gene therapy according to News-Medical.
MD Anderson Cancer Center:
A study identified a molecule that reduces age-related inflammation and improves brain and muscle function in preclinical models, with potential implications for age-related diseases.
The Targeting Aging with Metformin (TAME) trial is a large, long-term clinical trial aiming to evaluate the impact of metformin, a drug used to treat diabetes, on healthspan in older adults according to the American Federation for Aging Research.
Tech News Th June 14 2025 - genetics & viral vectors especially
64x Bio Unveils AAV Apex Suite to Address Gene Therapy Manufacturing Bottlenecks
64x Bio launches AAV Apex Suite, a high-yield manufacturing platform powered by VectorSelect, to tackle the cost and scalability challenges limiting gene therapy’s potential.
64x Bio, a biotechnology company focused on scalable solutions for advanced therapy production, has officially launched AAV Apex Suite, a high-performance product line aimed at solving one of gene therapy’s most pressing issues: manufacturing constraints. The launch follows the formation of strategic collaborations with five leading global biopharma and CDMO partners, underscoring industry demand for improved viral vector production.
Gene therapies hold transformative potential, but their reach has been limited by high manufacturing costs and low scalability. AAV Apex Suite tackles this challenge head-on, offering suspension-adapted HEK293 cell lines optimized for transient transfection and delivering titers exceeding E15 vg/L. These results have been independently validated across various serotypes and therapeutic payloads, consistently achieving high yield and quality.
"The grand challenges for gene therapies have shifted from target organ specificity and how to fit large genes into small capsids to the challenge of low-cost, high-quality manufacturing of AAV therapies. So it is with great pleasure that we see this milestone from 64x," said George Church, PhD, Co-founder of 64x Bio.
The AAV Apex Suite is powered by 64x Bio’s VectorSelect platform, an advanced system that maps the cellular pathways driving productivity. VectorSelect combines genetic and metabolic profiling to guide both cell line engineering and media formulation. As the platform’s dataset continues to grow, 64x Bio is applying computational tools to refine and accelerate new product development.
“Our goal is to enable gene therapies and next generation medicines to succeed by fixing the cost and scale problems that hold them back,” said Lexi Rovner, PhD, CEO and Co-founder of 64x Bio. “Our team has done incredible work to develop AAV Apex Suite as an initial demonstration of what our platform can achieve. We’re already building on this foundation and continuing to develop more that we’ll be sharing soon,” she added.
The launch of AAV Apex Suite comes at a critical time for gene therapy manufacturing. Five prominent biopharma and CDMO partners have already committed to collaborations, highlighting the urgency to resolve production limitations. While AAV Apex Suite currently supports transient production, 64x Bio is actively developing stable cell lines, with plans to expand the suite further.
Beyond the off-the-shelf capabilities of AAV Apex Suite, the company is also offering custom solutions through its VectorSelect platform. These custom projects extend beyond AAV, as 64x Bio continues to explore applications in broader advanced biologics manufacturing.
To learn more about AAV Apex Suite or discuss partnership opportunities, visit www.64xbio.com.
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viral vector production
Viral vector manufacturing is the process of producing viral vectors, which are modified viruses used to deliver genetic material into cells for various applications like gene therapy and vaccine development. The process involves several key steps: vector design, where the therapeutic gene is incorporated; host cell selection and genetic engineering; cell cultivation in bioreactors; virus production; harvesting; purification to remove impurities; quality control to ensure safety and potency; and formulation into a usable product.
Selecting the therapeutic gene and incorporating it into the viral vector's genome, while ensuring the vector is replication-deficient to prevent disease.
Moving towards suspension cell culture for increased scalability and cost-effectiveness.
Single-use technologies:
Utilizing disposable bioreactors and other components to reduce contamination risks and improve efficiency.
Process analytical technologies (PAT):
Implementing PAT to monitor and control the manufacturing process in real-time.
Advanced purification methods:
Developing more efficient and robust purification techniques to improve product quality
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simulations of viral vectors for gene therapy
Simulations of viral vectors for gene therapy involve using computational models to predict and optimize the behavior of these delivery vehicles. These simulations help researchers understand how viral vectors interact with cells and tissues, their potential toxicity, and how to improve their efficacy and safety. By modeling various factors like vector design, cellular environment, and immune response, these simulations guide the development of more effective and targeted gene therapies.
Here's a more detailed look:
What are Viral Vectors?
Viral vectors are essentially modified viruses used to deliver therapeutic genes into cells. They are designed to be safe and efficient delivery systems, replacing the virus's natural disease-causing genes with the desired therapeutic gene.
Why are Simulations Important?
Optimizing Vector Design:
Simulations allow researchers to test different vector designs, such as capsid types (e.g., AAV, lentivirus) and promoters, virtually before moving to costly and time-consuming experiments.
Predicting Immune Response:
Simulations can model how the body's immune system will react to the viral vector, helping to minimize potential adverse reactions.
Targeting Specific Cells and Tissues:
Simulations can help optimize the targeting of viral vectors to specific cell types or tissues, improving the effectiveness of gene therapy.
Assessing Safety:
By simulating various scenarios, researchers can identify potential risks associated with viral vectors and develop strategies to mitigate them, ensuring the safety of gene therapy treatments.
Guiding Clinical Trials:
Computational models can help design more efficient and informative clinical trials by predicting optimal dosages, delivery routes, and patient populations.
Simulating the flow of fluids (e.g., blood) and the movement of vectors within the body.
In Conclusion:
Simulations of viral vectors play a crucial role in advancing gene therapy. By providing valuable insights into vector behavior and interactions, they enable researchers to design safer, more effective, and more targeted gene therapies for a wide range of diseases
Thanks for your email; and greetings from northern California / greater SF Bay Area. I (at MIT OCW-centric wiki World University and School WUaS planned in all 200 countries, and in their main languages, with free-to-students' degrees from home - Bachelor, PhD, Law, MD, IB high sch/sim, AA/AS, and Master's ... AND with wiki schools eg https://wiki.worlduniversityandschool.org/wiki/Subjects in all 7159 known living languages for speakers of all of them ... with AI and ML and LLM and Gemini AI ) didn't participate in Gemini Academy but thanks for the connecting opportunity.
(from the main 'Nation States'' wiki subject at WUaS - https://wiki.worlduniversityandschool.org/wiki/Nation_States - from which all 200 major online research World University and Schools, in all 200 countries and in their main languages, will emerge).
Here are most ot the text response I added to the survey -
Mahattattva Gemini Academy
5th page
I didn't take the Gemini Academy program, but received this survey nevertheless, and as the founder and head of MIT OCW-centric wiki #GrowWithGoogleWUaS World Univ & Sch, am wondering how Gemini Academy could help our India World University and School teachers, in all ~22 scheduled languages for free-to-Indian-students' degrees from home.
I didn't take the Gemini Academy program, but received this survey nevertheless, and as the founder and head of MIT OCW-centric wiki #GrowWithGoogleWUaS World Univ & Sch, I appreciate the opportunity to connect with you at Mahattattva Gemini Academy ... and will invite you to the Monday at 10 am Pacific Time WUaS News and Q&A meetings in Zoom, AND wonder also how Mahattattva Gemini Academy could even help hire WUaS faculty in all 22 official languages in India for online teaching at students' home and with Gemini AI and MIT OCW +? Thanks.
Free-to-students' CC-4 licensed MIT OCW-centric wiki World University and School WUaS planned in all 200 countries, and in their main languages, with free-to-students' degrees from home - Bachelor, PhD, Law, MD, IB high sch/sim, AA/AS, and Master's AND with wiki schools in all 7159 known living languages for speakers of all of them ... with AI and ML and LLM and Gemini AI) is a private university in the USA, but may become part of the public education systems' universities in some or many of the approximately 199 countries out of ~200 countries (per the Olympics))
Founder, President, CEO, Professor, Presiding Clerk (in the manner of Friends / unprogrammed Quakers / Religious Society of Friend)
Anthropology, Sociology, Social Sciences, Information Technology Studies, Virtual World Studies, Arts and Humanities,
PPS searched on
Mahattattva Gemini Academy India
and found -
Workshops by Mahattattva at the Gemini Academy in India focus on teacher professional development. They aim to improve classroom productivity and creativity by using Google tools, including Google's Gemini AI.
Mahattattva conducts these workshops for educators throughout India, sometimes with their "Super Searchers Programme" to enhance information literacy. These workshops have been held for schools such as Adani Foundation schools, Delhi Public School branches, and educators across India.
These sessions demonstrate how Google's Gemini can improve teaching by increasing productivity, streamlining tasks, and promoting classroom creativity.
The Gemini Academy in India, through Mahattattva, appears to be a teacher training initiative. It focuses on incorporating Google's Gemini AI and related tools into the classroom to improve teaching and learning.
Note that there is also a "Gemini Institute" in Surat, Gujarat. It is important not to confuse the two entities
How was your experience with the Gemini Academy training?
You are receiving this email as you participated in Google’s Educator training called Gemini Academy. We're interested to see how the Gemini Academy has helped you amplify your teaching with Artificial Intelligence (AI).
The survey will take around 10 minutes to complete. The feedback from this survey will help to improve the training for you and other teachers.
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Dear Manattattva.in
Mahattattva, Regus Metropolitan Business Centre Level 5 & 6, JMD Regent Square, MG Road, Gurgaon- 122002, Haryana, India connect@mahattattva.in + 91 (0) 8810204772 + 91 (0) 124 6039611
As a Friendly unprogrammed Quaker (NtF, NtQ) leading or calling - to create free universal education with free-to-students' MIT OCW-centric World University and School WUaS Degrees in all ~200 countries and in their main languages, and free wiki schools for people-to-people wiki-teaching and wiki-leading in all 7,159 known living languages - WUaS Monthly Business Meeting (which has met on 3rd Saturdays at 10 am PT until now) is becoming WUaS Weekly Business Meeting / WUaS News and Q&A on Mondays at 10 am PT, loosely conducted in the manner of Friends/Quakers RSOF) due partly to the proximity and overlap of 3rd Saturdays and the following Monday's WUaS News and Q&A.
WUaS will now seek to email and reach out to all Universitians for WUaS Weekly Business Meeting / WUaS News and Q&A on Mondays at 10 am PT via email, and not just the Monday WUaS News and Q&A groups. (Please let WUaS know if you don't want to receive these invitations to the new WUaS Weekly Business Meeting / WUaS News and Q&A, and with - "'If you don't want to receive these, please reply with 'unsubscribe' in the body of the email, leaving the subject line intact. Thank you.')
You'll find below last month's MIT OCW-centric wiki #GrowWithGoogleWUaS World University and School WUaS News and Q&A recordings for your consideration.
The next MIT OCW-centric - https://ocw.mit.edu/ - wiki World Univ & Sch WUaS WEEKLY Business Meeting / News and Q&A meets on Monday June 23, 2025 at 10:00 AM Pacific Time, 1:00 PM ET (US & Canada), 5:00 PM GMT, 10:30 PM India Time, 1:00 AM Tu the next day Hong Kong Time (but please check your time converter from any of your 24 time zones to join this open WUaS Weekly Business Meeting) with Zoom URL here too -
MIT OCW-centric wiki #GrowWithGoogleWUaS World University and School WUaS News and Q&A recordings in the last month for your consideration -
Monday, May 26, 2025 Lava Beds National Monument, CA: Recording of #MITOCW-centric https://ocw.mit.edu/ wiki #GrowWithGoogleWUaS @WorldUnivAndSch @WUaSPress M 5/26/25 #WUaSNewsAndQA #ArtificialGeneralIntelligence & #WUaSresearch ~ * (WAS - M 05/26/25 open MIT OCW-centric wiki World Univ & Sch WUaS News and Q&A, with Zoom URL)
5/26 Recording #MITOCW-centric wiki #GrowWithGoogleWUaS @WorldUnivAndSch @WUaSPress #WUaSNewsAndQA
Monday, June 2, 2025 Weminuche Wilderness, CO: Recording of M 6/2/25 ocw.mit.edu& wiki #GrowWithGoogleWUaS @WorldUnivAndSch @WUaSPress #WUaSNewsAndQA #AGIwuAs * (was - M 06/2/25 open MIT OCW-centric wiki World Univ & Sch WUaS News and Q&A, with Zoom URL )
Recording of
M 6/2/25 ocw.mit.edu& wiki #GrowWithGoogleWUaS @WorldUnivAndSch @WUaSPress #WUaSNewsAndQA #AGIwuAs
Monday, June 9, 2025 Sierra Nevada red fox: Recording of 6/9/25 #MITOCW-centric wiki @WorldUnivAndSch @WUaSPress #WUaSNewsAndQA #RVE #AGIwuAs - * (was - M 06/9/25 open MIT OCW-centric wiki World Univ & Sch WUaS News and Q&A, with Zoom URL)
Recording of 6/9/25 #MITOCW-centric wiki @WorldUnivAndSch @WUaSPress #WUaSNewsAndQA #RVE #AGIwuAs -
Monday, June 16, 2025 Sky Lakes' Wilderness (Oregon): recording of 6/16/25 #MITOCW-centric wiki @WorldUnivAndSch @WUaSPress #WUaSNewsQA #InspireYouNOW #WikiTeach -How? * (was - M 06/16/25 open MIT OCW-centric wiki World Univ & Sch WUaS News and Q&A, with Zoom URL)
6/16/25 #MITOCW-centric wiki @WorldUnivAndSch @WUaSPress #WUaSNewsQA #InspireYouNOW #WikiTeach -How?
What is a church in a New Age context from the 1960s and 1970s?
In a New Age context from the 1960s and 70s, a "church" was less about a traditional hierarchical structure and more about a diverse, loosely connected network of individuals and groups pursuing spiritual growth and transformation outside mainstream religious institutions. New Age thinking emphasized a personal, experiential approach to spirituality, often drawing from various sources like Eastern religions, esoteric traditions, and psychology.
Here's a more detailed explanation:
Emphasis on Personal Experience:
New Age spirituality prioritized individual experience and intuition over dogma and institutional authority. Churches, in this context, became spaces for self-discovery, meditation, and connecting with a broader sense of universal consciousness.
Rejection of Traditional Structures:
Many New Agers were critical of traditional religious institutions, viewing them as rigid and disconnected from the real needs of individuals. They sought alternative communities and practices that offered more freedom and personal empowerment.
Eclecticism and Syncretism:
New Age thought freely blended ideas and practices from various traditions. For example, meditation techniques from Hinduism and Buddhism, concepts from Western esoteric traditions, and psychological insights were all integrated into New Age practices.
Focus on Holistic Health and Well-being:
The New Age movement also emphasized holistic health, encompassing physical, mental, and spiritual well-being. This led to the exploration of alternative therapies, yoga, and other practices aimed at personal transformation.
"Church" as a Metaphor:
For some, the idea of "church" in the New Age context became a metaphor for a state of interconnectedness and spiritual awareness rather than a physical building or organization.
In essence, the New Age movement in the 1960s and 70s offered an alternative to traditional religious structures by emphasizing personal spiritual exploration, the interconnectedness of all things, and a holistic approach to well-being
What is a church in a non-Christian context, and for example in terms of Heart Consciousness Church Harbin Hot Springs, hippies in the 1970s, and US federal and state of CA law?
In a non-Christian context, the term "church" can be understood more broadly as a place of worship, religious gathering, or spiritual community, not necessarily a building or institution connected to Christianity. The Greek word ekklesia, from which "church" is derived, originally simply meant "an assembly" or "gathering".
Here's how this concept applies to the examples you provided:
1. Heart Consciousness Church Harbin Hot Springs:
Non-Christian Church: Heart Consciousness Church at Harbin Hot Springs operates as a non-profit, spirit-oriented retreat center that embodies a New Age perspective,. They refer to their approach as "Heart Consciousness," which draws from the Human Potential Movement, the Natural Holistic Movement, and Universal Spirituality. Their purpose is to teach and demonstrate the experience of Heart Consciousness through various practices and activities offered at the retreat center, including silent meditation, yoga, and workshops.
Heart Consciousness Church's definition of "church": They describe their "church" as the "practical, living embodiment of Oneness," a unifying spiritual concept. They emphasize fostering a loving and accepting environment that welcomes people of all religious backgrounds, focusing on nature, meditation, and conscious touch.
In short, they see their "church" as a community and space dedicated to spiritual growth and the experience of "Oneness," rather than a traditional Christian church with specific dogma or rituals.
2. Hippies in the 1970s:
Spiritual Communities: The 1970s saw the rise of countercultural movements and spiritual communes. These communities, often referred to as "hippie utopias," established alternative lifestyles and spiritual practices that diverged from mainstream religion.
"Church" in this context: These communities might have used various terms to describe their gatherings or spiritual practices, such as "commune,""spiritual center," or "fellowship". Their "church" was essentially the collective body of believers or practitioners who came together to explore spirituality, shared values, and communal living.
The focus was on the community, the shared experiences, and the exploration of alternative spiritual paths, rather than traditional church structures or dogma.
3. US Federal and State of California Law:
Federal Definition (IRS): The Internal Revenue Code (IRC) does not specifically define "church," but the IRS generally uses a combination of factors to determine if an organization qualifies as a church for tax purposes. These include a distinct legal existence, a recognized creed and form of worship, definite ecclesiastical government, a formal code of doctrine and discipline, a distinct religious history, and other factors.
Focus on Function and Activities: The IRS emphasizes the organization's activities and function, looking for a congregation that assembles regularly to worship and carries out religious purposes.
California State Definition: California law has similar considerations for property tax exemptions. The "Church Exemption" applies to property used exclusively for religious worship services, and other activities reasonably necessary for the church's religious purposes. The state's courts have also emphasized the associational role of a church, meaning a body of believers that assembles regularly for worship.
In summary, while the word "church" can have a broad, non-Christian meaning referring to any religious gathering or spiritual community, the IRS and California state law have specific criteria for classifying an organization as a "church" for tax exemption purposes. These criteria focus on the organization's structure, activities, and the existence of a worshipping congregation, regardless of whether it aligns with traditional Christian practice
*
What is a church and what preceded the church idea in ancient Greece for example?
A Church
A church, in a Christian context, refers to the assembly or congregation of Christian believers, as well as the building or location where they gather for worship and fellowship. The term "church" comes from the Greek word "ekklēsia", which means "assembly" or "gathering". Early Christians adopted this term to refer to their gatherings for worship.
What preceded the concept of a "church" in Ancient Greece?
Before the rise of Christianity, Ancient Greece had a distinct religious system based on polytheism, involving a pantheon of gods and goddesses worshipped in temples and sanctuaries.
While Ancient Greece didn't have "churches" in the Christian sense, the word "ekklesia" itself had a significant role in their society. In classical Greece, the "ekklesia" was a secular assembly of citizens who gathered to discuss and decide matters of state, such as laws, policies, and judicial cases. This assembly met in a public building called the ekklesiasterion, often located in the city center.
So, in Ancient Greece, the "ekklesia" represented a secular gathering for political and social functions, while religious worship took place in temples and sanctuaries dedicated to various deities.
When early Christians began to form their communities, they adopted the term "ekklesia" to describe their religious gatherings, marking a transition from a political assembly to a religious one. This adoption highlights the evolution of the term's meaning and its adaptability to different contexts throughout histor
Greetings from MIT OCW-centric - https://ocw.mit.edu/ - wiki #GrowWithGoogleWUaS World Univ & Sch WUaS. WUaS Monthly Business Meeting which is becoming WUaS Weekly Business Meeting / WUaS News and Q&A on Mondays at 10 am PT as you may have read on Saturday, June 21, 2025.
As a Friendly unprogrammed Quaker (NtF, NtQ) leading or calling - to create free universal education with free-to-students' MIT OCW-centric World University and School WUaS Degrees in all ~200 countries and in their main languages, and free wiki schools for people-to-people wiki-teaching and wiki-leading in all 7,159 known living languages - WUaS Monthly Business Meeting (which has met on 3rd Saturdays at 10 am PT until now) is becoming WUaS Weekly Business Meeting / WUaS News and Q&A on Mondays at 10 am PT.
In talking with a Quaker Friend recently, key next steps forWUaS involve becoming accredited potentially with Middle States Commission on Higher Education with offices in the greater Philadelphia PA area (which involves having already matriculated students in part) - and to matriculate large numbers of students for free-to-students' MIT OCW-centric WUaS degrees, online from home.
On the WUaS wiki side, it would be great to be generating large numbers of wiki teachings, and potentially for those people who might be interested in teaching about something they love in the future too & see agenda item 5.
The next MIT OCW-centric - https://ocw.mit.edu/ - wiki World Univ & Sch WUaS News and Q&A meets on Monday June 9, 2025 now again at 10:00 AM Pacific Time, 1:00 PM ET (US & Canada), 5:00 PM GMT, 10:30 PM India Time, 1:00 AM Tu the next day Hong Kong Time (but please check your time converter from any of your 24 time zones to join this open WUaS Monthly Business Meeting) with Zoom URL here too -
Free MIT OCW-centric wiki World Univ & Sch is growing, and growing with #GrowWithGoogleWUaS, for free-to-students' online degrees - Bachelor, PhD, Law, MD IB high school/similar, AA/AS, and Master's - first in English, then in each of all ~200 countries and in their main languages, and see Peter Norvig's INCREDIBLE #ToolifyAIWUaS "Revolutionizing Education with Machine Learning and AI: #WorldUniversityInSchool" - https://www.toolify.ai/ai-news/revolutionizing-education-with-machine-learning-and-ai-2574306.
All the best, abolition-ally, Friendly greetings, Scott
Google #MahattattvaAI #GeminiAcademyIndia in #HaryanaIndia and how might #GrowWithGoogleWUaS #WUaSunivs in India's 22 scheduled #LanguagesWUaS collaborate with you & @SundarPichai with you to hire our first online #WUaSfaculty ... given WUaS's ~200 countries' official languages' foci?
Thanks for emailing this accelerator information, right after I emailed the MIT OCW-centric wiki World University and School M 6/23/25 WUaS News and Q&A / WUaS Weekly Business Meeting (loosely conducted in the Manner of Friends / Quakers) invitation last night -
As founder, president, CEO and professor at MIT OCW-centric wiki World University and School (and in a #GrowWithGoogleWUaS program) AND the WUaS Corporation, both planned in ~200 countries, for free-to-students' online from home MIT OCW-centric WUaS degrees - Bachelor, PhD, Law, MD, IB high school / similar, AA/AS, and Master's - and in 7159 known living languages as wiki schools too, I'm interested in applying for this. and by no means just for ~250 + planned online law schools in all ~200 countries and in their main languages (and see PS). World University and School is interested in developing with Artificial General Intelligence a realistic virtual earth as well, and see INCREDIBLE #ToolifyAIWUaS article by Peter Norvig "Revolutionizing Education with Machine Learning and AI" #WorldUniversityInSchool" updated March 2,2024 - https://www.toolify.ai/ai-news/revolutionizing-education-with-machine-learning-and-ai-2574306 in some of these WUaS regards.
Per Harvard and MIT Professor of Genetics' George Church' recent Tweet -
64x Bio launches AAV Apex Suite, a high-yield manufacturing platform powered by VectorSelect, to tackle the cost and scalability challenges limiting gene therapy’s potential.
Friday, June 20, 2025 Racoon: Are #ViralVectors a key path forward for #AgingReversal & #ExtremeLongevity #GeneticDrugTherapies & how can a #RealisticVirtualEarthForPharmacology help with scaling access to potential #GenetDrugTherapies & #ViralDrugTherapies ahead? * * Tech News Th June 14 2025 - genetics & viral vectors especially
64x Bio Unveils AAV Apex Suite to Address Gene Therapy Manufacturing Bottlenecks
64x Bio launches AAV Apex Suite, a high-yield manufacturing platform powered by VectorSelect, to tackle the cost and scalability challenges limiting gene therapy’s potential.
Viral Vectors and aging reversal and extreme longevity vaccines and how to help scale these with a #RealisticVirtualEarthForMedicine ?
A #RealisticVirtualEarthForMedicine in 1 #RealisticVirtualEarth w #Pegman as #AvatarAgentElectronicMedicalRecords w #MachineLearning @ #Gcell & #Gmolecule levels -thinking #GoogleStreetView w #TimeSlider #GMaps #GEarth #TensorFlowAI #TensorStore #RealisticVirtualEarthForSurgery ~
Announcing Segmentation-Guided Contrastive Learning of Representations (SegCLR), a method that trains rich, generic representations of cellular morphology and ultrastructure without manual effort and can identify cell types from only small cell fragments→ https://goo.gle/3G2uIEh
Clinical Trials with ML, AI & LLMs at WUaS with Kaiser Permanente ?
Wednesday, June 18, 2025 Cichlid: KP & clinical trials How many clinical trials has Kaiser Permanente in 8 US states been part of? 805 ... https://g.co/gemini/share/761b2d661c10 and could WUaS with KP do some clinical trials on aging reversal and extreme longevity genetic drug therapies when they're to that stage & re #YogaGenetics, eg higher, faster, stronger, more supple - http://www.scottmacleod.com/yoganotations.html - especially? * How best to dev #RandomizedClinicalTrials w #MLandAIWUaS & #LLMs @WorldUnivAndSch with #KPclinicalTrials in 8 US states & is in 805 https://g.co/gemini/share/761b2d661c10& re #AgingReversal & #ExtremeLongevity #GeneDrugTherapies when at that stage & re #YogaGenetics -http://www.scottmacleod.com/yoganotations.html ? * How will a #RealisticVirtualEarthForClinicalTrials in 1 iterating #RealisticVirtualEarth help potentially speed up #ClinicalTrials w #MLandAIWUaS & #LLMs @WorldUnivAndSch w #KPclinicalTrials in 8 US states - & in all ~200 countries & in main languages, & with #PacketsInTheMail ?
AND How will a #RealisticVirtualEarthForClinicalTrials in 1 iterating #RealisticVirtualEarth help potentially speed up #ClinicalTrials w #MLandAIWUaS & #LLMs @WorldUnivAndSch w #KPclinicalTrials in 8 US states - & in all ~200 countries & in main languages, & with #PacketsInTheMail ?
and could WUaS with KP do some clinical trials on aging reversal and extreme longevity genetic drug therapies when they're to that stage & re #YogaGenetics, eg higher, faster, stronger, more supple - http://www.scottmacleod.com/yoganotations.html - especially?
Google DeepMind Cyclone Prediction & How to grow a #RealisticVirtualHarbin in 1 iterating #RealisticVirtualEarth @demishassabis & #PredictTheWeather of #NeuralCascadesOfPleasure re #TheStudyOfBliss re studies of brain neural cascadings and #EnjoymentInLearning #ExploringBliss #VirtualHarbinHotSprings?
Tuesday, June 17, 2025 Apricot globemallow: Google DeepMind Cyclone Prediction & How to grow a #RealisticVirtualHarbin in 1 iterating #RealisticVirtualEarth @demishassabis #PredictTheWeather of #NeuralCascadesOfPleasure re #TheStudyOfBliss #EnjoymentInLearning #ExploringBliss #VirtualHarbinHotSprings?
How best for people to wiki-teach at MIT OCW-centric wiki World University and School in the open wiki subjects page - https://wiki.worlduniversityandschool.org/wiki/Subjects - for example by teaching to Youtube video about an academic subject or about something they love, and then adding the video to the relevant wiki subject?
World University and School (WUaS) aims to be a free, open, and MIT OCW-centric platform where anyone can contribute to global education. The approach of "wiki-teaching" by adding YouTube videos to relevant subject pages on their wiki is a key part of their vision. Here's a breakdown of how people can best do this, focusing on both academic subjects and topics they love:
General Best Practices for Wiki-Teaching on WUaS with YouTube Videos:
Understand the Wiki Ethos and WUaS Mission:
Openness and Collaboration: WUaS is built on the principles of open education and collaborative knowledge creation, similar to Wikipedia. Embrace this by being open to feedback and potential edits from others.
MIT OCW-centricity: While you can teach on any subject, understand that WUaS emphasizes STEM and aims to accredit courses based on quality open content like MIT OpenCourseWare. Aligning your teaching with academic rigor and clear learning objectives will be highly valued.
Free Education: The core mission is to provide free, quality education globally. Your contributions should reflect this spirit.
Choose Your Topic Wisely:
Academic Subjects: If teaching an academic subject, select a topic within your area of expertise. The goal is to provide accurate, well-explained information that aligns with established academic understanding.
Something You Love: If it's a passion project, ensure you have a deep understanding and can explain it clearly and engagingly. Even non-academic subjects can have educational value.
Create High-Quality YouTube Videos:
Clear Audio and Visuals: Good production quality is crucial for effective learning. Ensure your voice is clear, the lighting is adequate, and any visuals (slides, demonstrations) are easy to see and understand.
Concise and Focused: Break down complex topics into digestible chunks. Each video should ideally focus on a specific concept or skill. This makes it easier for learners to find what they need and prevents overwhelming them.
Engaging Presentation: Be enthusiastic and passionate about your subject. Use clear language, avoid excessive jargon, and consider incorporating examples, analogies, or real-world applications to make the content relatable.
Structured Content: Even for informal teaching, a basic structure (introduction, main points, summary, call to action/next steps) helps learners follow along.
Accessibility: Consider adding captions or providing a transcript for your videos to make them accessible to a wider audience, including those with hearing impairments or non-native English speakers.
Integrate Videos into the Wiki Effectively:
Find the Right Subject Page: Navigate to the relevant subject page on the WUaS wiki (e.g., https://wiki.worlduniversityandschool.org/wiki/Subjects). If a suitable page doesn't exist, consider creating one, following any wiki guidelines for new page creation.
Embedding Videos: Most wikis allow for easy embedding of YouTube videos. Look for an "edit" button on the wiki page, and then typically there will be an "insert video" or "embed media" option. You'll usually just need to paste the YouTube video URL.
Contextualize Your Video: Don't just embed the video. Add text around it to:
Introduce the Video: Briefly explain what the video is about and what learners will gain from watching it.
Provide Key Takeaways: Summarize the main points discussed in the video.
Offer Further Reading/Resources: Link to related sections on the wiki, MIT OCW courses, external academic articles, or other reputable sources.
Suggest Activities/Questions: Encourage active learning by posing questions for reflection or suggesting small activities related to the video's content.
Categorize and Tag: Ensure the wiki page (and by extension, your video's content) is properly categorized and tagged within the wiki's system. This improves discoverability.
Link to Relevant OCW Materials (where applicable): If your video teaches an academic subject, connect it to specific MIT OpenCourseWare courses or topics. This reinforces the MIT OCW-centric nature of WUaS.
Engage with the Community:
Monitor Your Contributions: Check back on the wiki page periodically to see if others have commented, edited, or added to your contribution.
Be Open to Collaboration: The wiki format thrives on collaborative editing. Be prepared for others to refine your content or add their own insights. This is how the collective knowledge grows.
Participate in Discussions: If there are discussion forums or talk pages associated with the subject, engage with other teachers and learners.
Example for "Teaching a Subject You Love" (e.g., Bread Baking):
Let's say you love teaching sourdough bread baking.
Create Videos:
Video 1: "Introduction to Sourdough Starter" (explaining what it is, how to feed it)
Video 2: "Mixing Sourdough Dough: Autolyse and Bulk Fermentation"
Video 3: "Shaping and Baking Sourdough"
(Each video would be concise, well-lit, with clear instructions and demonstrations.)
Wiki Integration:
Find or create a "Sourdough Baking" page under a broader "Culinary Arts" or "Home Skills" subject on WUaS.
On the "Sourdough Baking" page, create sections for each video.
For Video 1 (Sourdough Starter):
Text Introduction:"This video covers the fundamentals of creating and maintaining a sourdough starter, the living culture essential for sourdough bread."
Embed Video.
Key Takeaways:"You learned the ideal flour-to-water ratio, feeding frequency, and signs of a healthy, active starter."
Further Resources: Link to an external article on starter troubleshooting, or another WUaS page on "Microbiology of Fermentation" if it exists.
Activity:"Try feeding your starter and observe its activity over 12 hours. Share your observations in the comments!"
This structured approach, combining well-produced video content with thoughtful wiki integration, will maximize the educational impact and contribute effectively to the World University and School's mission.
WUaS Flagship Bookstores / Robotics' stores / Computer Stores, Grocery Stores - How best to proceed? In India, first in the state of Haryana as well as in the greater SF Bay Area ?
Agenda item B
Stanford Mine Pi Cryptocurrency, and WUaS coding for all 7.9 billion people, potentially to end poverty, and growing from coding for speakers of all 7,159 known living languages, and to create wiki free universal education,
Agenda item C
virtual Harbin Hot Springs for virtual soaking? What could WUaS ask monetarily for visitors interested in entering virtual Harbin, potentially differentially from those interested in participating in the study of bliss, ethnographically, and brain science-wise?
Could Toyota Motors design in a shower, toilet AND kitchen (to be emptied in a tank dump truck, one of which I saw in an unmarked white van emptying a RV near Toyota Palo Alto as I walked back to get my 5000 Mile Maintenance Required Soon Sienna after it was serviced on Sat 6/14/25) and in the back quarter of a 2028 Toyota Sienna Woodland minivan and regarding this great design -
and as #WUaSFacultyHomes and #WUaSStudentHomes too?
D i
and see -
? #WUaSFacultyHomes w AMAZING 2 gallon SHOWER that fits in a slot in the rear of #ToyotaSienna (w its storage space like a bathtub too): "Awesome Camper Shower (Pt 2))" https://youtu.be/lJg2bZOmpMw Pt 1 https://youtu.be/Upcy4HZasUM
.@ewarren on Harris campaign’s housing plan: “I’m 100 percent on this. We need the federal government to be a good partner in building more housing locally… it is a fabulous proposal.”
An #ArtificialGeneralIntelligenceHouse, re #AGIhouse? (@WorldUnivAndSch Am EXCITED by new potential for an #AGIRealisticVirtualEarth -re a #RealisticVirtualEarthForAGI to develop #AGIwuAs & #VirtualHarbin)
Thanks for emailing this accelerator information, right after I emailed the MIT OCW-centric wiki World University and School M 6/23/25 WUaS News and Q&A / WUaS Weekly Business Meeting (loosely conducted in the Manner of Friends / Quakers) invitation last night -
As founder, president, CEO and professor at MIT OCW-centric wiki World University and School (and in a #GrowWithGoogleWUaS program) AND the WUaS Corporation, both planned in ~200 countries, for free-to-students' online from home MIT OCW-centric WUaS degrees - Bachelor, PhD, Law, MD, IB high school / similar, AA/AS, and Master's - and in 7159 known living languages as wiki schools too, I'm interested in applying for this. and by no means just for ~250 + planned online law schools in all ~200 countries and in their main languages (and see PS). World University and School is interested in developing with Artificial General Intelligence a realistic virtual earth as well, and see INCREDIBLE #ToolifyAIWUaS article by Peter Norvig "Revolutionizing Education with Machine Learning and AI" #WorldUniversityInSchool" updated March 2,2024 - https://www.toolify.ai/ai-news/revolutionizing-education-with-machine-learning-and-ai-2574306 in some of these WUaS regards.
Per Harvard and MIT Professor of Genetics' George Church' recent Tweet -
64x Bio launches AAV Apex Suite, a high-yield manufacturing platform powered by VectorSelect, to tackle the cost and scalability challenges limiting gene therapy’s potential.
Friday, June 20, 2025 Racoon: Are #ViralVectors a key path forward for #AgingReversal & #ExtremeLongevity #GeneticDrugTherapies & how can a #RealisticVirtualEarthForPharmacology help with scaling access to potential #GenetDrugTherapies & #ViralDrugTherapies ahead? * * Tech News Th June 14 2025 - genetics & viral vectors especially
64x Bio Unveils AAV Apex Suite to Address Gene Therapy Manufacturing Bottlenecks
64x Bio launches AAV Apex Suite, a high-yield manufacturing platform powered by VectorSelect, to tackle the cost and scalability challenges limiting gene therapy’s potential.
Viral Vectors and aging reversal and extreme longevity vaccines and how to help scale these with a #RealisticVirtualEarthForMedicine ?
A #RealisticVirtualEarthForMedicine in 1 #RealisticVirtualEarth w #Pegman as #AvatarAgentElectronicMedicalRecords w #MachineLearning @ #Gcell & #Gmolecule levels -thinking #GoogleStreetView w #TimeSlider #GMaps #GEarth #TensorFlowAI #TensorStore #RealisticVirtualEarthForSurgery ~
Announcing Segmentation-Guided Contrastive Learning of Representations (SegCLR), a method that trains rich, generic representations of cellular morphology and ultrastructure without manual effort and can identify cell types from only small cell fragments→ https://goo.gle/3G2uIEh
grow @WorldUnivAndSch w free #WUaSDegrees in a #RealisticVirtualEarth & for #AcademicPublishing @WUaSPress to 1) paper & 2) brand new digital formats?
How best can free-to-students' #MITOCW-centric (in 5 langs now) grow @WorldUnivAndSch w free #WUaSDegrees in a #RealisticVirtualEarth in #GStreetView w #GTimeSlider as classrooms & #STEAMfieldsites & for #AcademicPublishing @WUaSPress to 1) paper & 2) brand new digital formats?
In @WorldUnivAndSch "Revolutionizing Education with Machine Learning and AI" :#WorldUniversityInSchool & w ~200 #WUaSunivs re INCREDIBLE #ToolifyAIWUaS art.-
It's fantastic that you're looking to contribute to World University and School (WUaS)! Their model of leveraging open educational resources like MIT OCW and encouraging community contributions via a wiki is very forward-thinking, especially in the age of AGI.
Let's break down how you can best teach at WUaS and handle citations, drawing from their stated mission and the nature of a wiki.
How to Teach at World University and School (@WorldUnivAndSch)
Focus on explanation and clarity: Even if it's a non-traditional academic subject (like your "Gray-Headed Swamphen" example), the goal is to educate. Explain concepts clearly, break down complex ideas, and provide context.
Show, don't just tell: For practical subjects (e.g., cooking, art techniques, birdwatching identification), videos are perfect for demonstrations.
Connect to broader knowledge (if possible): Can your passion topic be linked to scientific principles (e.g., bird migration to biology, cooking to chemistry), history, or culture? This adds academic depth.
Audience: Think about who would be interested in learning about this. Are you aiming for beginners, enthusiasts, or a more specialized audience?
Align with MIT OCW (where applicable): If you're teaching a subject covered by MIT OCW, consider how your video complements or extends those materials. You could provide:
Alternative explanations of complex topics.
Solved problems or worked examples.
Real-world applications or case studies.
Summaries or reviews of OCW modules.
Discussions of current research or recent developments in the field.
Structure for learning: Design your video as a mini-lesson. Have clear learning objectives for each video.
Build a series: For more complex academic subjects, consider a series of short videos on related topics. This creates a more comprehensive learning path.
Demonstrate pedagogical skills: Use clear communication, effective visuals, engage with potential questions (even if hypothetical), and summarize key points. This helps build your "online teaching experience" portfolio.
2. Create Your YouTube Video(s):
Quality Matters:
Audio: Clear, crisp audio is paramount. Invest in a decent microphone if you can.
Video: Good lighting, stable camera, and clear visuals (slides, whiteboard, demonstrations) are essential.
Conciseness: Aim for focused videos, ideally under 10-15 minutes for individual concepts. Longer videos can be broken down.
Engagement: Speak clearly, vary your tone, use visuals effectively, and maintain eye contact (if on camera).
Content Considerations for WUaS:
Open License: Ensure your video content is open for educational use. While YouTube generally has its own terms, WUaS's mission implies content that can be freely accessed and used for learning.
No Paywall/Ads (ideally): For a free educational platform, linking to videos with excessive or disruptive ads might be less ideal.
If not, consider creating a new page for it. Follow existing naming conventions and categorization.
Edit the Wiki Page:
Look for the "Edit" tab at the top of the page.
Wikis typically use a simplified markup language (like MediaWiki, similar to Wikipedia).
Embedding YouTube: The most common way is using a specific tag or template. For MediaWiki, it's often {{#ev:youtube|VIDEO_ID}} or similar, where VIDEO_ID is the unique part of the YouTube URL (e.g., for youtube.com/watch?v=dQw4w9WgXcQ, the ID is dQw4w9WgXcQ). The exact syntax might be on their FAQ or by looking at how other videos are embedded.
Add Context and Structure:
Introduction: Briefly explain what your video is about and its relevance to the subject.
Learning Objectives: What will a viewer learn from this video?
Summary/Key Points: Briefly summarize the main takeaways.
Pre-requisites/Next Steps: Suggest what a learner should know before watching or what they could explore afterward.
Related Resources: Link to relevant MIT OCW courses, other WUaS wiki pages, external articles, or books.
Discussion Prompts: Encourage interaction by posing questions for learners to consider or discuss.
Categorization: Ensure the wiki page is correctly categorized so it appears under relevant subject headings.
4. Gaining Online Teaching Experience through WUaS:
Portfolio Building: Every video and wiki contribution you make is a demonstrable piece of your online teaching experience.
Feedback: Engage with any comments or edits on your wiki pages. This shows your ability to adapt and collaborate.
Refinement: Use the experience to refine your teaching style, video production, and content structuring.
Networking (Indirect): While direct networking might be limited, your contributions are public and showcase your expertise to anyone visiting WUaS.
Accreditation (Future): WUaS has a long-term goal of accreditation. Contributing now aligns you with that vision and puts you in a good position if they develop more formal "instructor" roles in the future.
Citation Format for WUaS Wiki
The World University and School wiki, being a wiki, likely follows a flexible but consistent approach to citations, similar to Wikipedia. Looking at their FAQ (https://wiki.worlduniversityandschool.org/wiki/Frequently_Asked_Questions) and other wiki pages would be your best bet, but generally:
No specific, rigid style is usually enforced across all content. However, the principle is to provide enough information for others to verify the source.
Inline citations are key. This means immediately after the fact, quote, or idea you're citing, you'll place a reference.
A "References" or "Bibliography" section at the end of the page. This lists the full details of all sources cited in the text.
General Guidelines (assuming a Wikipedia-like MediaWiki environment):
Use <ref> tags for inline citations:
To cite something in the text, you'd typically enclose the citation information within <ref> and </ref> tags.
Example: "The Gray-Headed Swamphen is known for its vibrant plumage."
At the bottom of the page, include a <references/> tag (or {{reflist}} if they use that template) to automatically generate the list of references.
What information to include for different source types:
Your own YouTube Video:
Your Name (or Channel Name). "Video Title."YouTube, Date Uploaded, URL.
Example: Macleod, Scott. "My Sourdough Starter Guide."''YouTube'', June 26, 2025, https://www.youtube.com/watch?v=your_video_id.
An MIT OCW Course:
MIT OpenCourseWare. "Course Number: Course Title." Massachusetts Institute of Technology, Year. URL.
Example: MIT OpenCourseWare. "6.0001 Introduction to Computer Science and Programming in Python." Massachusetts Institute of Technology, 2016. https://ocw.mit.edu/courses/6-0001-introduction-to-computer-science-and-programming-in-python-fall-2016/.
A Blog Post (like your Scott MacLeod blog):
Author Last Name, First Name. "Title of Post."Blog Name, Date of Post, URL.
Author (if known). "Article Title."Website Name, Date Published (or last updated), URL.
Example: National Geographic. "New Discoveries in Human Origins."''National Geographic'', January 15, 2025, https://www.nationalgeographic.com/your-article-link.
Tips for Citation on a Wiki:
Consistency: While a specific style might not be mandated, try to be consistent with the elements you include for each type of source.
Clarity: Make it easy for someone else to find your source.
Avoid self-promotion (beyond educational content): While you're teaching, focus the content on the subject matter, not on promoting your personal brand outside the educational context.
By following these guidelines, you can effectively contribute to World University and School, share your knowledge, gain valuable online teaching experience, and properly attribute your sources within their open wiki environment.
*
and asked Gemini AI further in voice -
How with artificial general intelligence further and to inspire people to teach at MIT opencourseware Centric Wiki World University and school can I share with people how do I teach at World University in school about what I love or for online teaching experience etcetera and what citation format do I use for adding what I teach or a resource to the World University and School ?
It's exciting that you're interested in contributing to World University and School (WUaS) and leveraging the power of MIT OpenCourseWare! Here's a breakdown of how to approach your questions:
How Artificial General Intelligence (AGI) Can Further and Inspire Teaching at WUaS
AGI has the potential to revolutionize open education at WUaS in several ways:
Personalized Learning Paths: AGI could analyze a student's learning style, prior knowledge, and goals to create highly customized learning paths, drawing from the vast resources of MIT OCW and other open educational resources (OER). This would make learning more efficient and engaging.
Intelligent Tutoring Systems: AGI-powered tutors could provide instant feedback, answer questions, and offer explanations in various subjects, acting as a tireless and accessible resource for students worldwide.
Automated Content Creation and Curation: AGI could assist in identifying, organizing, and even generating new educational content, making it easier for educators at WUaS to create comprehensive courses and wikis. This could include summarizing complex topics, creating practice problems, or even generating new perspectives on existing materials.
Global Collaboration and Translation: AGI can facilitate seamless communication and collaboration among students and educators from different linguistic backgrounds, automatically translating resources and discussions. This is particularly relevant for WUaS's goal of reaching all 7,000+ languages.
Enhanced Accessibility: AGI can adapt educational materials for diverse learners, including those with disabilities, by automatically generating captions, audio descriptions, and alternative formats.
Data-Driven Insights: AGI can analyze learning data to identify areas where students struggle, allowing WUaS to continuously improve its courses and teaching methodologies.
AGI's ability to automate tedious tasks, personalize learning, and bridge communication gaps could significantly inspire more people to teach and learn at WUaS by making the process more efficient, accessible, and impactful.
How to Share What You Teach and Teach at World University and School
World University and School is built on a wiki model, similar to Wikipedia, which means it's designed for open, editable teaching and learning. Here's how you can generally contribute:
Direct Wiki Contributions: The most direct way to teach at WUaS is to add your content directly to their wiki. This could involve:
Adding YouTube videos of yourself teaching: If you have video lectures or tutorials, you can embed them on relevant subject pages.
Creating or editing wiki pages: You can write out lessons, create exercises, or curate resources on subjects you're passionate about.
Curating MIT OCW content: A key aspect of WUaS is its MIT OCW-centric approach. You can link to relevant MIT OCW courses and materials, adding your own explanations, context, or supplementary resources.
Contacting WUaS Directly: For more structured teaching opportunities, or to discuss potential degree programs and accreditation, the WUaS website suggests emailing them at Meeting @ WorldUniversityAndSchool.org. This would be the best way to explore how your teaching experience or specific passions could be integrated into their curriculum.
Leveraging Your Online Teaching Experience: Highlight your online teaching experience when communicating with WUaS. They are a global, online institution, so your expertise in virtual pedagogy, curriculum development for online environments, and engaging remote learners would be highly valuable. You can offer to:
Develop full online courses.
Lead online study groups or discussions.
Create interactive learning modules.
Design assessments suitable for online learning.
What Citation Format to Use for Adding What You Teach or a Resource to WUaS
Since WUaS is "like Wikipedia with CC-4 MIT OCW," the citation format will likely be a hybrid approach, emphasizing clear attribution and adherence to Creative Commons licensing.
For MIT OpenCourseWare (OCW) Content:
MIT OCW specifically requests the following citation format for their materials, which are typically licensed under Creative Commons BY-NC-SA:
[Author's Name]. [Course Title]. [Term]. Massachusetts Institute of Technology: MIT OpenCourseWare, [URL]. License: Creative Commons BY-NC-SA.
Example:
Jane Dunphy. 21F.225/21F.226 Advanced Workshop in Writing for Science and Engineering (ELS). Spring 2007. Massachusetts Institute of Technology: MIT OpenCourseWare, https://ocw.mit.edu/. License: Creative Commons BY-NC-SA.
If you use MIT OCW materials on a website (which the WUaS wiki is), you must also include a copy of the MIT OpenCourseWare Creative Commons license (CC BY-NC-SA) or a clear and reasonable link to its URL (https://ocw.mit.edu/terms/) with every copy of the MIT materials or the derivative work you create from it.
For Your Own Content or Other Resources:
Clear Attribution: Always clearly state that the content is your own work or properly attribute any other sources you use.
Standard Citation Style (e.g., APA, MLA, Chicago): While a wiki might not enforce a strict academic citation style for every inline reference, it's good practice to provide full bibliographic information for any external resources you cite, especially for academic or factual claims. You could choose a widely recognized style like APA, MLA, or Chicago, and apply it consistently for your external references.
Creative Commons Licensing for Your Own Work: Consider explicitly licensing your own contributions to WUaS under a Creative Commons license (e.g., CC BY-SA, CC BY-NC-SA) to align with the open educational philosophy of WUaS and MIT OCW. This allows others to freely use, adapt, and share your work under specified conditions. You can typically add a small notice at the bottom of your wiki page indicating the license.
Hyperlinks: For online resources, always include direct hyperlinks to the original source.
General Principle for Wiki Contributions:
The key for a wiki environment like WUaS is transparency and verifiability. Make it easy for others to see where information comes from, especially if it's not your original thought.
By embracing AGI's potential, actively contributing to the wiki, and diligently citing sources, you can play a significant role in the development and expansion of World University and School.
to William, Vicki, me, president@worlduniversityandschool.org, Dean, medianthro-easaonline.org@lists.easaonline.org
Dear William / Bill Kelly (Vicki Nash whom I met at Harvard Law Emeritus Professor Charlie Nesson's home in Cambridge MA in around 2006 at a brunch at a celebration for the Berkman Center of Internet and Society at Harvard Law School, Dean MacCannell whom I know from the UC Berkeley Tourism Studies' Working Group in the Anthropology department there and see PPPS, MediaAnthro), All,
Dear William / Bill Kelly (Vicki Nash whom I met at Harvard Law Emeritus Professor Charlie Nesson's home in Cambridge MA in around 2006 at a brunch at a celebration for the Berkman Center of Internet and Society at Harvard Law School, Dean MacCannell whom I know from the UC Berkeley Tourism Studies' Working Group in the Anthropology department there and see PPPS, MediaAnthro), All,
Thanks for this information about an Oxford "Digital Ethnography" course beginning soon - https://www.conted.ox.ac.uk/courses/digital-ethnography. And greetings from near Harbin Hot Springs' Heart Consciousness Church, my physical-digital ethnographic field site, and for my next Harbin Hot Springs' ethnographic book project, to be developed for research in something like Google Street View with time slider, and also for publishing (both to 1) Paper, and 2) to new digital formats such as the the back of digital glasses, and in #WUaSMultimediaRooms even, thus potentially reinventing the book even). As founder and president of MIT OCW-centric wiki #GrowWithGoogleWUaS World University and School for free-to-students' online WUaS degrees from home in each of all ~200 countries and in their main languages, WUaS seeks to further develop a #RealisticVirtualEarth #ForEverything (including #ForSTEM #ForEthnography - #ForMuseums & #ForLibraries, all, ever in all languages ever - and #ForArchaeology #ForPaleontology, and a #RealisticVirtualEarthForHistory with #GTimeSlider ... and see #Twitter and #LinkedIN for these #hashtags) as classrooms and field sites too, and see Peter Norvig's INCREDIBLE #ToolifyAIWUaS article - https://www.toolify.ai/ai-news/revolutionizing-education-with-machine-learning-and-ai-2574306 - mentioning a virtual Harbin for the first time ever (other than by me and MIT OCW-centric wiki World University and School of which again I'm the founder and head), and also to study bliss in virtual Harbin (and search on these words). Bill, since you went to the University of California, Davis, have you ever visited Harbin Hot Springs' Heart Consciousness Church?
Here attached is the draft first chapter of my "Naked Harbin Ethnography: Hippies, Warm Pools, Counterculture, Clothing-Optionality & Virtual Harbin" (2016 Academic Press at World University and School) which I sent to the University of Toronto Press in 2016.
MacLeod Naked Harbin Chapter 1 U Toronto Press.pdf
My "Naked Harbin Ethnography" comes in conversation with Tom Boellstorff's "Coming of Age in Second Life: An Anthropologist Explores the Virtually Human" (2008 - https://press.princeton.edu/books/paperback/9780691168340/coming-of-age-in-second-life). Might you be planning to read some of this in the upcoming Oxford "Digital Ethnography" course?
It's long been a goal of mine to develop an online virtual Harbin Hot Spring for ethnographic study and research, and with an anthropological research group, and for anthropological field site generation, and to study -
Virtual Harbin generation (realistic) Realistic virtual earth / cosmos generation, group build-able at atomic/molecular, neuronal/cellular, and streetview/behavioral levels Avatar robotics' design and printing of 3D place / avatar bots Brain chemistry - a) loving bliss and b) consciousness as awareness - research and modeling (re e.g. modeling mouse and fly brains with AI) Wiki ethnography generation Field work to actual Harbin Hot Springs
Ethno-Wiki-Virtual-World-Graphy (as a new social science theory and method, as well as STEM-Wiki-Virtual-World-Graphy)
In what ways might we explore further some of this, if at all, in your upcoming Oxford "Digital Ethnography" course beginning soon? Do you think your Oxford "Digital Ethnography" students might be interested in visiting virtual (or actual) Harbin Hot Springs for anthropological and ethnographic study and research?
1 William H. Kelly Stipendiary Lecturer, St. Hugh's College Research Affiliate, School of Anthropology and Museum Ethnography (SAME) University of Oxford Email: william.kelly@anthro.ox.ac.uk
1 c William Kelly is an Anthropologist of Japan and Research Affiliate at the School of Anthropology and Museum Ethnography (SAME), University of Oxford.
"...co-founder and co-convenor of the Oxford Digital Ethnography Group (OxDEG), creator and convenor of the Digital Methods module for research students in Anthropology and occasional convenor of the Digital Ethnography option at the Oxford Internet Institute"
William H. Kelly Stipendiary Lecturer, St. Hugh's College Research Affiliate, School of Anthropology and Museum Ethnography (SAME) University of Oxford Email: william.kelly@anthro.ox.ac.uk
PPS
You can visit the Harbin Gatehouse here in Google Street View with time slider, and 'walk' down the road to Middletown, but not yet up into Harbin Hot Springs and the pool area, for example -
which is where I'm seeking for a #RealisticVirtualHarbin to emerge (e.g. in a kind of wiki Google Street View with a time slider).
per
Scott GK MacLeod's Naked Harbin Ethnography: Hippies, Warm Pools, Counterculture, Clothing-Optionality & Virtual Harbin (2016, Academic Press at World University and School) by Scott MacLeod sgkmacleod@worlduniversityandschool.org
Foreword by Nelson H.H. Graburn UC Berkeley Professor Emeritus of Sociocultural Anthropology
How best to create a realistic virtual Harbin Heart Consciousness Church (with ministers) and to study bliss in virtual Harbin? And please see Peter Norvig's INCREDIBLE #ToolifyAIWUaS article - https://www.toolify.ai/ai-news/revolutionizing-education-with-machine-learning-and-ai-2574306 - mentioning a virtual Harbin for the first time ever (other than by me and MIT OCW-centric wiki World University and School of which I'm the founder and head).
PPPS
2016-2017 Colloquium Series The Tourism Studies Working Group is pleased to announce
ACTUAL-VIRTUAL HARBIN HOT SPRINGS AND TOURISM: "Naked Harbin Ethnography"
Scott MacLeod Founder, World University and School
I have in mind at WUaS developing a #RealisticVirtualHarbin Hot Springs vis-a-vis a concurrent #RealisticVirtualEarth ... and such that scientists and researchers could develop brainwave headset technologies such that we could visit virtual Harbin eg in the back of our digital glasses or in multimedia rooms from our bathtubs (for the warm water 'relaxation response' meditation from home) and to study further such brain freedoms, I posit, academically and scientifically ... and regarding possibly #RockAndRollThusness brainwave freedoms too ...
Retweeting - 1st lines of #NakedHarbinEthnography: "After you check in at the gate at #HarbinHotSprings, a #Harbinresident who has worked there for years often says "#GoPlay" http://scottmacleod.com/ActualVirtualHarbinBook.html ... How to explore in #RealisticVirtualHarbin @HarbinBook for #EthnoWikiVirtualWorldGraphy ?
I have been asked to circulate information about the following, which may be of interest to doctoral and/or advanced research students:
The Department of Continuing Education, University of Oxford, is offering a summer short course, Digital Ethnography, which will run between 16th July and 5th September. The main aims of the course, which is targeted to doctoral and/or advanced research students in the social sciences, is to equip students with skills in digital research methods for purposes of advancing their own research objectives and to familiarise them with key research themes and issues, as well as related academic literature. Students also conceive, develop and undertake (with guidance) a small-scale, independent, hands-on digital research project over the duration of the course, the results of which are discussed in the final session.
The course is offered free to students enrolled in an Oxford award-bearing DPhil programme when the course starts and at a reduced fee for students enrolled in an award-bearing postgraduate programme at Oxford (or any other higher educational institution) when the course begins. For further details and/or to enrol, please visit the course website at the above link.
All best regards,
Bill Kelly
William H. Kelly
Stipendiary Lecturer, St. Hugh's College Research Affiliate, School of Anthropology and Museum Ethnography (SAME)
How best to interoperate in a #RealisticVirtualEarthForGenetics the best #FilmTo3DApps - re microscopy & electron microscopy - @ molecule & cell levels that scientists are using for #AgingReversal #ExtremeLongevity gene Research @WorldUnivAndSch? Gemini: https://g.co/gemini/share/a8cf3a93b7c3 ~
How best to interoperate in a #RealisticVirtualEarthForGenetics the best #FilmTo3DApps - re microscopy & electron microscopy - @ molecule & cell levels that scientists are using for #AgingReversal #ExtremeLongevity gene Research @WorldUnivAndSch? Gemini: https://g.co/gemini/share/7ed0acf798cd ~
How best to interoperate in a realistic virtual Earth for genetics and think Google Street View with time slider and at the Google cell view level and Google molecule view level the best film to 3D apps regarding microscopy and electron microscopy at molecule and cell levels that scientists are using for aging reversal extreme longevity Gene research ?
This is a fascinating and ambitious vision, combining macroscopic geospatial data with microscopic biological information for aging reversal and gene research. Let's break down how best to interoperate in such a realistic virtual Earth, moving from the macro to the molecular, and the tools involved.
Interoperability in a Realistic Virtual Earth for Genetics
The core idea is to create a seamless, multi-scale virtual environment where scientists can navigate from a global view down to the individual molecule, with genetic and temporal data integrated at every level.
1. Google Street View with Time Slider (Macro Level - Environmental & Population Genetics)
Current Capabilities: Google Earth already offers Street View with a historical imagery time slider.This allows users to observe environmental changes over time, which can be crucial for studying population genetics, epidemiological trends, and the impact of environmental factors on health and longevity across different demographics.
Enhancements for Genetics Research:
Data Overlays: Integrate demographic data (age, health statistics, reported longevity trends), environmental data (pollution levels, access to green spaces, climate data), and even anonymized genomic data (e.g., prevalence of certain genetic markers in a region) as overlay layers.
AI-driven correlations: Develop AI to identify correlations between environmental factors, demographic shifts, and genetic predispositions visible in the Street View data over time. For instance, do areas with certain pollution levels show higher rates of specific age-related diseases or lower average lifespans?
Simulation & Prediction: Use the historical data to run simulations of how environmental changes might impact genetic health and longevity in the future.
This is where the vision gets more futuristic. Imagine being able to "zoom in" from a Street View location directly into the cellular architecture of an organism or tissue sample relevant to that location.
Data Integration:
3D Histology/Pathology Scans: Integrate high-resolution 3D scans of human tissues and organs (e.g., from biopsy samples, organoids, or even cadaver studies) that are linked to specific geographic locations or patient cohorts.
Cell Atlas Integration: Link to existing cell atlases (like the Human Cell Atlas) that map cell types and their gene expression profiles across different tissues.
Live Cell Imaging Data: Incorporate real-time or time-lapse microscopy data of living cells, allowing scientists to observe cellular processes, aging hallmarks (e.g., senescence, mitochondrial dysfunction), and gene expression changes in dynamic 3D.
Interactivity & Navigation:
Virtual Reality (VR)/Augmented Reality (AR): VR/AR platforms would be essential for truly immersive navigation and interaction with complex 3D cellular data. Users could "walk through" a tissue, examine individual cells, and even "teleport" to specific organelles.
Semantic Zoom: As you zoom in, the virtual environment seamlessly transitions from macroscopic maps to detailed 3D cell models, intelligently loading relevant data.
AI-guided Exploration: AI could highlight areas of interest based on genetic markers, disease states, or specific cellular processes being investigated for aging reversal.
The ultimate zoom: from a cell, you can dive into the molecular machinery, visualize gene expression, protein interactions, and even DNA structure.
Data Integration:
Structural Biology Data: Integrate PDB (Protein Data Bank) structures, cryo-EM reconstructions of protein complexes, and atomistic simulations of molecular dynamics.
Genomic/Epigenomic Data: Visualize DNA sequences, epigenomic modifications (methylation, histone modifications), and gene regulatory networks in 3D.
Transcriptomics/Proteomics Data: Display real-time or snapshot data on gene expression (RNA levels) and protein abundance/localization within the cellular context.
Interactivity & Analysis:
Molecular Docking & Simulation: Allow users to virtually "manipulate" molecules, simulate drug-target interactions, or model gene editing interventions.
Genetic Pathway Visualization: Visualize entire biochemical pathways and gene regulatory networks in 3D, showing how aging reversal interventions might impact these pathways.
Interactive Gene Editing: Potentially, a virtual "CRISPR tool" where users could visualize the effects of gene edits on DNA and protein structure.
Best Film-to-3D Apps & Tools for Microscopy (Molecule & Cell Levels)
The "film-to-3D" aspect implies taking 2D microscopy images (from various slices or angles) and reconstructing them into a 3D model.
For Electron Microscopy (EM) and Cryo-Electron Tomography (Cryo-ET):
EM provides ultra-high resolution, crucial for molecular and sub-cellular structures.Cryo-ET allows 3D reconstruction of biological samples in their native state.
Software for 3D Reconstruction:
IMOD: A powerful open-source package widely used for electron tomography, offering tools for alignment, reconstruction, segmentation, and visualization.
Eman2/3: Another open-source suite for single-particle cryo-EM and cryo-ET, focusing on high-resolution structure determination.
Amira/Avizo (Thermo Fisher Scientific): Commercial software offering comprehensive tools for 3D visualization, analysis, and reconstruction of various imaging modalities, including EM.Thermo Fisher also has Phenom 3D Reconstruction Software for their desktop SEMs.
ZEISS EM Software (ZEN core, Atlas 5, SmartSEM): These are primarily for operating ZEISS EM systems and managing data, but they often integrate with or export to 3D visualization tools.
cryoDRGN: Developed by the E.Z. Lab at Princeton, this software uses machine learning for 3D reconstruction of dynamic protein structures from cryo-EM data, particularly useful for understanding molecular flexibility.
For Light Microscopy (including Super-Resolution and Confocal):
These techniques are essential for live-cell imaging and understanding cellular dynamics.
ImageJ/Fiji: A widely used, open-source image processing and analysis platform with numerous plugins for 3D reconstruction, visualization, and quantitative analysis of microscopy data. It's highly customizable.
Imaris (Oxford Instruments): A leading commercial software for 3D/4D image processing and analysis of microscopy data, offering advanced visualization, segmentation, and tracking capabilities.
Arivis Vision4D: Another powerful commercial solution for handling large-scale 3D/4D microscopy datasets, particularly strong in its ability to manage and visualize massive files.
ZEISS ZEN software family: Specific modules within ZEN (like ZEN Intellesis for AI-powered segmentation) support 3D reconstruction and visualization from their confocal and super-resolution microscopes.
Huygens (Scientific Volume Imaging): Known for its deconvolution algorithms, which significantly improve the clarity and resolution of 3D microscopy data, making subsequent 3D reconstruction more accurate.
CellProfiler: While more focused on high-throughput image analysis, it can process and quantify features from 2D and 3D images, which can then be visualized in other tools.
Napari: A Python library for interactive, multi-dimensional image visualization, offering a flexible platform for developers and researchers comfortable with scripting.
For Atomic Force Microscopy (AFM):
AFM provides nanoscale topographical and mechanical information.
Gwyddion: An open-source software for SPM (Scanning Probe Microscopy) data analysis, including AFM. It offers powerful tools for visualizing, processing, and analyzing 2D and 3D AFM data.
NanoScope Analysis (Bruker): Software specifically designed for Bruker AFM systems, offering comprehensive analysis and visualization of AFM data. Bruker also offers Relate software for correlative microscopy, combining AFM with other modalities.
OriginLab OriginPro: A general-purpose data analysis and graphing software that can handle and visualize 3D surface plots from AFM data.
Dedicated AFM Software (e.g., Redux AFM software by ICSPI): Many AFM manufacturers provide their own proprietary software for data acquisition, processing, and 3D visualization, optimized for their specific hardware.
Tools and Concepts for Interoperability
Beyond individual 3D reconstruction software, achieving the "Google Molecule View" within a "Virtual Earth" requires:
Standardized Data Formats: Development and adoption of universal data formats for microscopy, genomic, proteomic, and structural biology data to ensure seamless transfer and integration between different software and platforms. OME-TIFF for microscopy, PDB for structural data, and established genomic formats are good starting points, but even more integrated formats will be needed.
Cloud Computing & AI: The sheer volume of data (from global satellite imagery to atomic structures) necessitates cloud-based platforms for storage, processing, and real-time streaming. AI will be crucial for:
Automated Segmentation and Annotation: Identifying cells, organelles, and molecules within vast datasets.
Feature Extraction: Pinpointing relevant genetic markers or aging hallmarks.
Predictive Modeling: Simulating the effects of interventions.
Unity/Unreal Engine: Game engines are powerful platforms for creating highly realistic and interactive 3D environments. They can be leveraged to build the "Virtual Earth" and integrate scientific data.
Custom VR/AR applications: Projects like BioVR are exploring VR for visualizing biological data, but more comprehensive platforms are needed.
Open-source VR frameworks: Libraries that allow scientists to build custom VR visualizations of their data.
APIs (Application Programming Interfaces): Robust APIs will be essential for different software components to communicate and share data, allowing the "Street View" to seamlessly connect to "Cell View" and "Molecule View."
Ontologies and Knowledge Graphs: To make the vast amount of biological and geospatial data searchable and interoperable, a comprehensive system of ontologies and knowledge graphs would be vital, linking genetic information to cellular processes, tissue types, environmental factors, and geographic locations.
For Aging Reversal & Extreme Longevity Gene Research
The virtual Earth concept offers immense potential:
Disease Modeling: Simulate how genetic mutations or environmental stressors lead to age-related diseases.
Drug Discovery & Testing: Virtually screen potential aging reversal compounds by modeling their interactions with cellular and molecular targets.
Personalized Medicine: Integrate individual genomic and health data into the virtual environment to develop personalized aging reversal strategies.
Educational & Outreach Tools: Create highly engaging and intuitive platforms for educating the public and future scientists about genetics, aging, and biotechnology.
This vision requires significant interdisciplinary collaboration between computer scientists, biologists, geneticists, and experts in visualization and AI. It's a grand challenge, but one with the potential to revolutionize how we understand and manipulate biology.
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What are the top film-to-3D applications - re microscopy and electron microscopy - at the molecular level and the cellular level ...?
What are the top film-to-3D applications - re microscopy and electron microscopy - at the molecular level and the cellular level that scientists are using for aging reversal and extreme longevity Research into genetics? Gemini: https://t.co/gxnKZmcLrZ& https://t.co/NBUDFANDmX ~
Scientists are increasingly leveraging advanced 3D microscopy and electron microscopy techniques, combined with sophisticated 3D reconstruction software, to delve into the molecular and cellular mechanisms of aging and longevity. This allows for unparalleled insights into genetic regulation, protein interactions, and cellular architecture in the context of aging reversal.
Here are some of the top film-to-3D applications and software used in this field:
I. For Microscopy (Molecular and Cellular Level):
Cryo-Electron Tomography (Cryo-ET): This is a cutting-edge technique that allows for the visualization of biomolecules within their native cellular environment at sub-nanometer resolution. It's crucial for understanding "molecular sociology"– how molecules interact in their cellular context. Scientists are using Cryo-ET to:
"Molecular Movies": Capturing dynamic processes like DNA unzipping by helicase enzymes, which has direct implications for DNA replication and repair, key processes in aging.
3D Reconstruction of Organelles: Visualizing and quantifying the morphology of organelles (e.g., mitochondria, ER) in 3D to understand their changes during aging and in response to interventions.
Protein Complexes in situ: Revealing the precise arrangement and interactions of protein complexes within cells.
Super-Resolution Microscopy (e.g., STORM, PALM, STED): These techniques overcome the diffraction limit of light microscopy, allowing for imaging at much higher resolutions (down to tens of nanometers). When combined with 3D reconstruction, they are used to:
Visualize Chromatin Structure: Studying how chromatin organization changes with age and in genetic interventions for longevity.
Track Molecular Dynamics: Observing the movement and interactions of individual molecules within cells in real-time and 3D.
Map Protein Distribution: Precisely locating and quantifying proteins involved in aging pathways.
Light Sheet Microscopy: Ideal for imaging large, transparent samples (like whole organs or embryos) with minimal phototoxicity, enabling long-term 3D imaging of biological processes. While less about "film-to-3D" in the traditional sense, the acquired Z-stacks are used for 3D reconstruction and analysis of:
Tissue-level Aging Changes: Observing how cellular organization and tissue structure change across larger scales during aging.
Developmental Biology in Longevity: Understanding how early life events and developmental processes might impact later-life longevity.
Live-Cell Imaging with 3D Reconstruction: Systems like the Nanolive 3D Cell Explorer allow for label-free, non-invasive 3D imaging of living cells over extended periods. This is vital for:
Real-time Cellular Aging: Observing dynamic changes in cell morphology, organelle behavior, and cellular processes as cells age or undergo rejuvenation.
Drug Screening: Assessing the impact of potential anti-aging compounds on cellular health and function in 3D.
II. For Electron Microscopy (EM) (Molecular and Cellular Level):
Focused Ion Beam-Scanning Electron Microscopy (FIB-SEM): This technique allows for serial sectioning of a sample with a focused ion beam, followed by imaging of each exposed surface with an SEM. This produces high-resolution 3D datasets of cellular and tissue structures. It's particularly useful for:
Cellular Organelle Networks: Reconstructing intricate networks of organelles like mitochondria, ER, and lysosomes in 3D, providing insights into their interconnectedness and how they are affected by aging.
Synaptic Plasticity and Aging: Studying the 3D architecture of synapses in the brain to understand age-related cognitive decline and potential reversal.
Tissue Ultrastructure: Analyzing the 3D organization of cells and extracellular matrix within tissues as they age.
Serial Block-Face Scanning Electron Microscopy (SBF-SEM): Similar to FIB-SEM, SBF-SEM also automates the process of cutting and imaging, but typically for larger volumes. It's used for:
Comprehensive Cell Volume Reconstruction: Reconstructing entire cells and their internal components in 3D at high resolution.
Multi-scale Imaging: Bridging the gap between light microscopy and higher-resolution TEM.
III. Key 3D Reconstruction and Analysis Software:
The raw 2D image stacks ("film") generated by these powerful microscopes are then processed and reconstructed into 3D models using specialized software. Some of the most widely used include:
Amira-Avizo Software (Thermo Fisher Scientific): A powerful and versatile platform for visualizing, processing, and analyzing complex 3D image data from various microscopy techniques. It's extensively used for:
Segmentation: Defining and isolating specific structures (e.g., organelles, cells) within the 3D dataset.
3D Reconstruction: Generating detailed 3D models from serial sections or Z-stacks.
Quantitative Analysis: Measuring volumes, surface areas, distances, and other morphological parameters of reconstructed structures.
Machine Learning-based segmentation: Increasingly integrating AI for faster and more accurate segmentation of complex biological structures.
ImageJ/Fiji (open-source): A highly popular and versatile image processing program with numerous plugins for 3D reconstruction, visualization, and analysis. It's a go-to for many labs due to its open-source nature and extensive community support.
IMARIS (Oxford Instruments): A commercial software package offering advanced 3D/4D visualization, analysis, and interpretation of microscopy data, including capabilities for tracking objects over time, surface rendering, and co-localization analysis.
MBF Bioscience Software (e.g., Neurolucida 360, TissueMaker): These are specialized for neural reconstruction and tissue analysis, capable of generating high-resolution 3D models of neurons and entire organs from serial sections. They are valuable for studying age-related changes in the nervous system.
Dragonfly (Object Research Systems Inc.): A comprehensive software platform for 3D/4D image processing, visualization, and analysis across various scientific fields, including life sciences. It offers advanced segmentation and measurement tools.
MCell: A modeling tool specifically for simulating cellular signaling in 3D subcellular environments, allowing researchers to study the stochastic behavior of molecules and their interactions.
Importance for Aging Reversal and Extreme Longevity Research:
These 3D imaging and reconstruction techniques are fundamental to aging research because they allow scientists to:
Uncover Structural Changes: Precisely visualize how cells, organelles, and tissues change their 3D architecture with age, providing clues about the underlying mechanisms of aging.
Identify Biomarkers: Discover novel morphological biomarkers of aging or rejuvenation at the subcellular level.
Evaluate Interventions: Assess the impact of genetic manipulations (e.g., CRISPR-Cas9 for gene editing), caloric restriction, senolytics, or other anti-aging interventions on cellular and molecular structures in 3D.
Understand Disease Mechanisms: Gain deeper insights into age-related diseases like neurodegeneration, cancer, and metabolic disorders by studying their structural basis in 3D.
Develop New Therapies: Inform the design of new therapeutic strategies by providing a detailed 3D understanding of biological processes.
By providing unprecedented spatial resolution and contextual information, 3D microscopy and electron microscopy are revolutionizing our understanding of aging and paving the way for advancements in longevity research.
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What are the top film-to-3D applications - re microscopy and electron microscopy - at the molecular level and the cellular level that scientists are using for aging reversal and extreme longevity Research into genetics?
What aging reversal and longevity genetic drug therapies are Merck developing and testing?
Based on the information available, Merck is not actively developing or testing genetic drug therapies specifically focused on aging reversal or longevity in a general sense.
However, Merck does conduct research and develop treatments for age-related diseases:
WINREVAIR (sotatercept-csrk): This drug has been approved and tested for Pulmonary Arterial Hypertension (PAH), a condition often affecting older adults.
Restoret (MK-3000): Merck, through its acquisition of EyeBio, is developing this drug for retinal diseases like diabetic macular edema and age-related macular degeneration, conditions associated with aging.
Bomedemstat (MK-3543): This investigational drug is being evaluated for myeloproliferative neoplasms, a group of blood cancers more common in older individuals.
KEYTRUDA (pembrolizumab): This immunotherapy is used to treat various cancers, some of which are more prevalent in older populations, like certain types of lung cancer and melanoma.
LAGEVRIO (molnupiravir): This antiviral drug is being tested for use in high-risk adults with COVID-19, which can disproportionately impact older individuals.
It's important to note that developing drugs for age-related diseases is distinct from pursuing therapies aimed at reversing aging itself. While some of these drugs may improve health outcomes for older individuals, their primary focus isn't on extending lifespan or reversing the biological aging process.
Merck has previously studied:
Lonafarnib: This drug showed promise in treating children with progeria, a rare premature aging disorder, but Merck had no plans to develop it for general anti-aging purposes.
Other aging research:
Senolytics: There is research into senolytics, drugs that eliminate senescent cells associated with aging and age-related diseases, being tested in clinical trials for conditions like idiopathic pulmonary fibrosis and diabetic kidney disease.
Gene therapy: Research into gene therapies for aging and longevity is ongoing, with some approaches showing promise in animal studies, but these are not currently linked to Merck's pipeline.
In summary: While Merck has developed and is testing drugs for diseases associated with aging, it doesn't appear to be pursuing genetic drug therapies specifically for aging reversal or general longevity enhancement. Their focus remains on treating age-related conditions and improving healthspan, rather than lifespan extension
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university knowledge generation and research in a realistic virtual earth ...
Best platforms now for #RealisticVirtualEarth #RealisticVirtualEarthForGenetics @ #CellLevel & #MoleculeLevel #ForAgingReversal & #ForExtremeLongevity #GeneticDrugTherapies that might interoperate w #GStreetView w #GTimeSliders? https://g.co/gemini/share/1e3339ff39f6 & https://g.co/gemini/share/8bf7498a4f0f ~
Best current platforms for #RealisticVirtualEarth #RealisticVirtualEarthForGenetics @ #CellLevel & #MoleculeLevel #ForAgingReversal & #ForExtremeLongevity #GeneticDrugTherapies that might interoperate with #GStreetView with #GTimeSliders ?
In seeking to develop a realistic virtual Earth for genetics for aging reversal genetic drug therapies for extreme longevity genetic drug therapies, what are the three or four best platforms for modeling the molecular world of the human body that might interoperate with Google Street View with time sliders at the street view level?
Developing a "realistic virtual Earth for genetics for aging reversal genetic drug therapies for extreme longevity" is an incredibly ambitious and complex undertaking, pushing the boundaries of current technology. It requires not only sophisticated molecular modeling but also a way to contextualize this at a human and even population level, potentially integrating with environmental factors.
Here are three or four of the best platforms and approaches for modeling the molecular world of the human body, with a focus on their potential (or current limitations) for interoperability with something like Google Street View:
What they are: These are the workhorses for simulating the behavior of atoms and molecules over time. They are fundamental for understanding protein folding, protein-ligand interactions (crucial for drug discovery), membrane dynamics, and much more at the atomic level. They use classical mechanics to calculate forces between atoms and integrate Newton's equations of motion.
Strengths for your goal:
Atomic-level detail: Essential for understanding how genetic drugs interact with specific proteins, enzymes, or DNA/RNA structures to achieve their therapeutic effect.
Dynamic behavior: Allows you to observe how molecules move, bind, and change shape, which is vital for drug efficacy and understanding biological processes related to aging.
Drug discovery applications: Widely used in pharmaceutical research to predict binding affinities, screen potential drug candidates, and optimize lead compounds.
Interoperability with Google Street View (Challenges and Opportunities):
Scale Mismatch: MD simulations operate at the nanometer scale (individual molecules), while Google Street View operates at the human-perceptible, geographic scale (meters to kilometers). There's a massive leap in abstraction.
Data Integration: The challenge is to link a molecular event (e.g., a drug binding to a protein) to its macroscopic effect on a human being, and then to a population level, and finally to a specific location on Earth.
Potential Future Links: Imagine a "digital twin" of a person, where molecular models are running "inside" them. This digital twin could be situated within a virtual environment. While direct interoperability with Street View for real-time molecular data isn't feasible now, the results of molecular simulations (e.g., predicting a drug's efficacy for a specific genetic profile) could feed into higher-level models that are then visualized geographically. For example, a Street View scene could show areas with higher concentrations of individuals predisposed to certain aging-related conditions, and a "time slider" could show how their health metrics change with new therapies based on molecular models.
2. Systems Biology and Multiscale Modeling Platforms (e.g., Virtual Cell (VCell), Copasi, Physiome Project, Human Digital Twin initiatives)
What they are: These platforms aim to model biological systems at multiple scales, from genes and proteins to cells, tissues, organs, and even whole organisms. They integrate various types of biological data (genomic, proteomic, metabolomic, clinical) and use mathematical equations and computational frameworks to simulate complex biological processes.
Strengths for your goal:
Bridging Scales: Crucial for connecting molecular events to cellular and organismal phenotypes, which is essential for understanding the impact of genetic therapies on aging reversal and longevity.
Network Analysis: Can model gene regulatory networks, signaling pathways, and metabolic networks that are implicated in aging.
Predictive Power: Can be used to predict the effects of genetic interventions on complex biological systems, allowing for the in-silico testing of drug therapies.
Population-level considerations: Some approaches are beginning to incorporate variability between individuals to model population responses.
Interoperability with Google Street View (Challenges and Opportunities):
Indirect Link: Similar to MD, direct real-time integration is unlikely. However, the outcomes of these multi-scale simulations (e.g., predicted changes in healthspan or lifespan for individuals with specific genetic markers) could be overlaid onto a "virtual Earth."
Demographic and Environmental Context: If you have geographically linked demographic data (e.g., anonymized genetic predispositions in different neighborhoods), the results of these models could inform a "time slider" on Street View, showing simulated health changes over time in those areas, possibly correlated with environmental factors (pollution, access to resources, etc.). The "virtual Earth" would provide the environmental context for the simulated human populations.
"Digital Twin" Concepts: The most promising avenue for interoperability lies in the development of "digital twins" of human beings, which could then be placed within a simulated Street View environment.
3. AI/Machine Learning Platforms for Drug Discovery and Biology (e.g., AlphaFold, DeepMind's other biology work, various AI drug discovery startups like Insilico Medicine, Recursion Pharmaceuticals)
What they are: These platforms leverage advanced AI and machine learning techniques (deep learning, generative AI, reinforcement learning) to accelerate various stages of drug discovery, from target identification to lead optimization. They can predict protein structures, identify novel compounds, design de novo molecules, and analyze vast datasets of biological and chemical information.
Strengths for your goal:
Speed and Scale: AI can process and learn from enormous datasets much faster than traditional methods, accelerating the identification of potential aging reversal targets and therapies.
Novel Discovery: Generative AI can propose entirely new molecular structures with desired properties, potentially leading to breakthrough therapies.
Predictive Accuracy: AI models are becoming increasingly accurate at predicting molecular interactions, toxicity, and pharmacokinetics.
Personalized Medicine: AI is crucial for analyzing individual genomic data to tailor therapies for extreme longevity.
Interoperability with Google Street View (Challenges and Opportunities):
Data-driven insights: AI platforms can generate insights about genetic predispositions or drug efficacy that could be visualized on a virtual Earth. For instance, if an AI predicts that a certain genetic therapy would be particularly effective for individuals with a specific genotype, and you have anonymized geospatial data on the prevalence of that genotype, you could visualize the "impact" of the therapy across different regions in Street View.
"Time Slider" for Scenarios: The AI models could run different "what-if" scenarios (e.g., if a drug is widely adopted, what's the projected impact on longevity in different communities over time?), and these projections could be represented through the "time slider" feature on a geospatial platform like Street View.
Environmental Data Integration: AI can also be used to integrate environmental data (from Google Street View imagery, satellite imagery, etc.) with biological and health data to identify correlations that impact aging. For example, AI could analyze street-level images for greenspace, air quality indicators, or walkability, and correlate these with health outcomes derived from molecular and systems biology models.
Interoperability with Google Street View and Time Slider at the Street View Level:
The core challenge is the vast difference in scale and data types. Direct, real-time molecular modeling within a Street View environment is not currently feasible or meaningful. However, the results and insights derived from these sophisticated molecular and systems biology models could be visualized and explored within a geospatial context:
Virtual Human "Avatars" / Digital Twins: The most promising bridge. Imagine creating highly detailed "digital twins" of humans, each incorporating their unique genetic profile. These digital twins would be informed by molecular simulations and systems biology models to predict their health trajectories, including aging processes and responses to therapies. These digital twins could then be "placed" within a virtual Earth environment (like a sophisticated Google Street View).
Time Slider: The "time slider" would then demonstrate how the health and aging markers of these digital twins evolve over time, both naturally and under the influence of various genetic drug therapies. You could see aggregated demographic health changes reflected in the Street View environment.
Visualization: This could involve abstract representations (e.g., color-coding buildings or areas based on health metrics, or showing simulated "healthy years lived" for populations).
Geospatial Health Data Overlays: The molecular and systems biology models would inform predictive models of health and disease at a population level. This data could then be overlaid onto Google Street View.
Example: Areas with a high prevalence of genetic markers for a particular aging-related disease could be highlighted. As a new drug therapy is simulated, the "time slider" could show the predicted reduction in disease burden or increase in average lifespan in those areas.
Environmental Factors: Google Street View offers visual information about the built environment. Integrating this with health outcomes (e.g., correlating presence of green spaces with predicted longevity improvements based on genetic predisposition and lifestyle) would add another layer of realism.
Data Visualization Tools: Specialized visualization platforms (e.g., CesiumJS, Unity/Unreal Engine for scientific visualization, or custom web-based GIS applications) would be needed to bridge the gap between scientific models and a visually rich environment like Street View. These tools would consume the outputs of the molecular and systems biology models and render them in a geographically meaningful way.
In summary, while direct "molecular Street View" is not a concept, the powerful predictive capabilities of molecular dynamics, systems biology, and AI platforms will be essential to generate the data that, when intelligently visualized, can create a "realistic virtual Earth" for exploring the impact of genetic therapies on aging and longevity within a geospatial context. The key is in abstracting the detailed molecular insights into meaningful, population-level health indicators that can be mapped and tracked over time.
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what are the three or four best platforms to model the human body at the cellular level for aging reversal genetic drug therapies and extreme longevity genetic drug therapies that would interoperate with Google Street View with a Time slider at the street view level and also with platforms at the molecular level
Modeling the human body at the cellular level for aging reversal and extreme longevity genetic drug therapies, while also interoperating with Google Street View and molecular-level platforms, is a highly ambitious and cutting-edge endeavor. No single platform currently offers this full spectrum of capabilities. However, we can identify several leading platforms and approaches that contribute to different aspects of this vision, and discuss how they might be integrated:
Core Platforms for Cellular-Level Modeling (Aging & Longevity)
These platforms excel at simulating cellular processes, genetic interactions, and age-related changes.
Strengths: These tools allow for the creation of detailed, mechanistic models of cellular pathways, networks, and even whole-cell behaviors. They can incorporate genetic and epigenetic data, simulate gene expression, protein interactions, metabolic flux, and signaling cascades. This is crucial for understanding how genetic drug therapies might impact cellular function and aging pathways. The Physiome Project, in particular, aims to develop a comprehensive physiological framework, from genes to whole organisms.
Application to Aging/Longevity: They can model hallmarks of aging (e.g., cellular senescence, mitochondrial dysfunction, altered nutrient sensing) and simulate the effects of gene editing (e.g., CRISPR-based therapies) or drug interventions on these processes.
Interoperability: Many of these platforms use standardized formats (e.g., SBML, CellML) which facilitate data exchange and integration with other computational tools.
AI/Machine Learning Platforms for "Omics" Data Integration (e.g., Google DeepMind's AlphaFold, specialized bioinformatics platforms):
Strengths: AI is revolutionizing the analysis of vast biological datasets (genomics, transcriptomics, proteomics, epigenomics). Platforms like AlphaFold (for protein folding prediction) are critical for understanding the molecular targets of genetic drugs. Other AI platforms can identify patterns in "aging clocks" (epigenetic markers predicting biological age), discover new senolytic compounds (drugs that clear senescent cells), and predict therapeutic targets.
Application to Aging/Longevity: Essential for identifying new genetic targets for intervention, predicting drug efficacy, and personalizing therapies based on individual omics profiles. They can also help in analyzing single-cell sequencing data to understand cell-specific aging processes, as exemplified by tools like SenePy for identifying senescent cells.
Interoperability: Often provide APIs or data export capabilities for integration with other analytical or modeling platforms. Google's own involvement in DeepMind and other AI initiatives positions it well for such integration.
Strengths: While primarily at the molecular level, these platforms are crucial for understanding how genetic changes (e.g., a modified protein) impact molecular interactions and function. They simulate the physical movements of atoms and molecules over time, providing insights into drug-target binding, protein stability, and enzyme activity.
Application to Aging/Longevity: Directly relevant for designing and refining genetic drug therapies by modeling how a gene-edited protein interacts with its cellular environment or how a small molecule drug binds to a target.
Interoperability: Output data can inform cellular-level models (e.g., reaction rates, binding affinities) and are foundational for understanding the precise mechanisms of genetic interventions.
Bridging to Google Street View with a Time Slider
This is the most speculative and currently unfulfilled aspect of your request. Integrating cellular-level models with geographic information systems (GIS) like Google Street View would require significant innovation in data visualization and multi-scale modeling.
Hypothetical Approaches for Interoperability with Google Street View:
Geospatialized Health Data & Predictive Epidemiology: Imagine a future where anonymized health data (including biological aging markers derived from cellular models) could be aggregated and visualized geographically. A "time slider" at the Street View level could show trends in population health metrics (e.g., prevalence of age-related diseases) over time, potentially correlated with environmental factors visible in Street View. This wouldn't be direct cellular modeling in Street View, but rather a high-level aggregation of health outcomes that are ultimately rooted in cellular processes.
Augmented Reality (AR) Overlays: In a more futuristic scenario, AR could overlay abstract representations of cellular health or genetic therapy impact onto physical locations in a Street View-like interface. For instance, a "healthy" or "aged" score for a demographic group in a particular neighborhood could be visualized.
"Digital Twin" Concepts: The concept of a "digital twin" of a human body, incorporating cellular-level data, is emerging. Extending this to a population level, and then linking it to geographic locations, would be a monumental undertaking, but conceptually possible. A "time slider" would then demonstrate predicted changes in these "digital twins" over time due to various factors, including the impact of widespread genetic drug therapies.
Challenges for Google Street View Interoperability:
Data Privacy and Anonymization: Integrating individual health data with geographical locations raises significant privacy concerns.
Scale Disparity: The scale difference between a cell (10−6 meters) and a street (102 meters) is immense. Directly visualizing cellular processes within Street View is not feasible. The connection would have to be through abstract, aggregated health metrics.
Computational Intensity: Real-time cellular modeling for entire populations, and then linking it to dynamic geospatial data, would be computationally prohibitive with current technology.
Conclusion
While no single platform perfectly fulfills your vision today, the most promising path involves a combination of:
Computational Systems Biology Platforms: For mechanistic cellular modeling of aging and longevity pathways.
AI/Machine Learning Platforms: For analyzing "omics" data, discovering genetic targets, and predicting drug efficacy.
Molecular Dynamics Simulation Software: For detailed understanding of molecular interactions crucial for drug design.
The interoperability with Google Street View and a time slider would likely occur at a more abstract, aggregated level, potentially through advanced geospatial health analytics and augmented reality concepts, rather than direct visualization of individual cells within a street scene. This would represent a truly interdisciplinary grand challenge in computational biology, data science, and urban planning
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AND . . .
Universities are increasingly leveraging realistic virtual earth environments and virtual reality (VR) technologies for knowledge generation, research, and enhanced learning experiences.
Here's how these technologies are being used:
Immersive Research Environments: VR can create virtual research environments that allow students and researchers to explore and interact with complex research settings, including virtual laboratories, field sites, or specialized equipment setups. For example, Penn State researchers have recreated ancient Mayan ruins in virtual reality for historical and geographical studies.
Virtual Field Experiences: Platforms like Google Earth and other interactive simulations offer virtual field trips, allowing students to explore ecosystems, historical sites, or geological formations from anywhere in the world, overcoming logistical challenges of traditional field trips.
Simulating Earth Systems: Institutions like NASA use platforms like the Virtual Earth System Laboratory to host simulations related to glaciers, ice sheets, sea level change, and the solid earth, enabling researchers to model and understand the impact of climate change.
Interactive Learning and Training: Virtual environments can be used for simulations that mimic real-world scenarios, allowing students to practice and hone their skills in a safe and controlled setting. This is particularly useful in fields like engineering, where students can conduct virtual experiments, manipulate variables, and analyze data in real-time.
Data Visualization and Exploration: Platforms combining different visualization modalities like the one developed by MIT, Harvard, and Stanford, allow users to interactively and collaboratively explore climate data, fostering better understanding and communication of climate science.
Promoting Collaboration: Virtual research environments and platforms allow researchers and students from different locations to collaborate, share data, and work together on projects in a virtual setting.
Experiential Learning: Virtual farms or similar simulations allow students to gain practical experience in fields like agriculture through interactive activities like fertilization and irrigation calculations in a controlled environment.
Developing Critical Thinking and Problem-Solving: Interactive simulations and virtual worlds encourage exploration, experimentation, and critical thinking by allowing students to engage with complex problems and concepts in a hands-on way.
Enhancing Engagement and Motivation: The immersive nature of VR increases student engagement and motivation by making learning more interactive and enjoyable. Students become active participants, leading to a deeper understanding and appreciation for the subject matter.
Examples:
MIT's ThreeDWorld (TDW): A platform that simulates realistic 3D environments with real-world physics, enabling research in AI, cognitive science, and human-robot interaction.
University of Montana Western's Virtual Field Experiences: Utilizes GIS data and 360-degree interactive environments to allow students to conduct virtual field research of Greenland.
University of Miami's Virtual Experiences Simulation Lab (VESL): An interdisciplinary hub for developing immersive media projects and applied research in fields like extended reality (XR).
NASA Sea Level Change Portal's Virtual Earth System Laboratory: Hosts simulations related to glaciers, ice sheets, and sea level change.
PhET Interactive Simulations at the University of Colorado Boulder: Creates free interactive math and science simulations that engage students through an intuitive, game-like environment.
Overall, the use of realistic virtual earth environments and VR in universities is leading to more engaging, interactive, and effective learning experiences, facilitating cutting-edge research, and preparing students for careers in emerging fields
Brainstorm: @geochurch w @dwarkesh_sp "A Cure for Aging by 2050? - George Church" https://youtu.be/N6WdeclE__w "A Billion Years of Evolution in a Single Afternoon -..." https://youtu.be/olmHHxFQwxo How to further dev #AgingReversal & #ExtremeLongevityGenetics in #RealisticVirtualEarth?
How to further develop AgingReversal & ExtremeLongevity GeneticTherapies in a #RealisticVirtualEarth ?
quotes -
"8 billion of us that have missed the Germline Opportunity"
127:48 Harvard and MIT
129 How do you spot talent?
Self- selecting
Nice
Multidisciplinarity
1:33
with AGI Almost Perfect Heatlh
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What #AcademicBooks have been written & published with #XTwitter or #Twitter posts as kinds of paragraphs, if any?
What #AcademicBooks have been written & published with #XTwitter or #Twitter posts as kinds of paragraphs, If any? Were these possible books published & printed to both paper & digital formats? What did doing so do in the book? Concision, bring in a social media conversation...?
What #AcademicBooks have been written & published with #XTwitter or #Twitter posts as kinds of paragraphs, If any? Were these possible books published & printed to both paper & digital formats? What did doing so do in the book? Concision, bring in a social media conversation...?
What academic books have been written & published with #XTwitter or #Twitter posts as kinds of paragraphs, If any? Were these possible books published & printed to both paper & digital formats? What did doing so do in the book? Concision, bring in a social media conversation...?
Yes, there are academic books that utilize or discuss X/Twitter posts (formerly Twitter) as part of their content or analysis.
Books that analyze X/Twitter as data or subject matter:
The Discourse of Customer Service Tweets: Planes, Trains and Automated Text Analysis by Ursula Lutzky studies how customer service interactions on Twitter are conducted, using a corpus of over 1.5 million tweets.
Tweelyzer. An Approach to Sentiment Analysis of Tweets by Durgesh Samariya discusses a method for automatically classifying sentiment in tweets, analyzing opinions expressed in tweets about various topics.
Natural Language Processing for Social Media, Third Edition by Anna Atefeh Farzindar and Diana Inkpen explores the use of natural language processing (NLP) to analyze social media data, including Twitter, and highlights its challenges compared to traditional text analysis.
Books that may contain X/Twitter examples as they discuss social media:
Text as Data: A New Framework for Machine Learning and the Social Sciences by Justin Grimmer, Margaret E. Roberts, and Brandon M. Stewart is a guide for using computational text analysis, including machine learning tools, to study the social world using textual data, which could include social media posts like tweets.
Analyzing Media Messages: Using Quantitative Content Analysis in Research by Daniel Riffe, Stephen Lacy, Brendan R. Watson, and Jennette Lovejoy provides guidance on quantitative content analysis research, and its latest edition includes updates on the uses of social media in content analysis research.
Working with Text: Tools, Techniques and Approaches for Text Mining by Emma Tonkin and Gregory J.L Tourte provides an introduction to text mining and its applications, including the use of text mining packages with data drawn from social media.
Books that discuss the phenomenon of X/Twitter's role and influence:
Extremely Online by Taylor Lorenz analyzes how online influence, including on Twitter, has reshaped media, content creation, and even aspects of the economy.
The Twittering Machine by Richard Seymour offers a critical analysis of the effects of social media (including Twitter) on personal and political life, discussing how its features can perpetuate addictive cycles and impact the information landscape.
Tweets and the Streets by Paolo Gerbaudo examines the role of social media platforms like Twitter in facilitating social movements and activism.
Important Considerations for using X/Twitter data in academic works:
Copyright and Fair Use: When reproducing tweets, particularly those of public figures, it is crucial to understand and adhere to copyright and fair use guidelines, sometimes requiring permission.
Data Restrictions: Twitter's terms of service (TOS) typically restrict the sharing of full tweets in datasets; researchers often share tweet IDs instead, which require "hydration" to retrieve the associated text and metadata.
Citation Practices: Academic style guides, such as MLA, provide formats for citing social media content, including tweets.
While X/Twitter posts may not always be structured as paragraphs within academic texts, they are frequently used as primary source data for analysis, examples to illustrate concepts, or as the subject of academic inquiry themselves, particularly in fields like communication studies, social science, and digital humanities.
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What did Luther Burbank do in Santa Rosa & Sebastopol with plant breeding, and when?
What did #LutherBurbank do in Santa Rosa & Sebastopol w #PlantBreeding & from when to when & can I see this in a #RealisticVirtualEarthForAgriculture a #RealisticVirtualEarth #ForGardens #ForNuseums & think #GStreetView w #GTimeSlider @WorldUnivAndSch? https://g.co/gemini/share/05c5a5acac51 ~
What did Luther Burbank do in Santa Rosa & Sebastopol with plant breeding and from what year to what year and can I see this in a realistic virtual Earth for agriculture, a realistic virtual Earth for Gardens and museums and think Google Street View with time slider at this point?
Luther Burbank, a renowned horticulturist, made Santa Rosa, California, his home and the center of his groundbreaking plant breeding work for over 50 years, from 1875 until his death in 1926.
In Santa Rosa, and at his experimental farm in nearby Sebastopol, Burbank conducted large-scale plant hybridization experiments, often involving millions of plants at a time. His objective was to improve the quality of plants and increase the world's food supply.
His significant contributions include introducing over 800 new varieties of plants, suchially:
* Fruits: Over 200 varieties, including the famous Santa Rosa plum, the 'Flaming Gold' nectarine, stoneless prunes, and improved apples, cherries, and pears. His work with plums alone spanned 40 years and resulted in over 40 new varieties.
* Vegetables: Many varieties, most notably the Burbank potato (Russet Burbank), which he developed in Massachusetts but used the proceeds from its sale to move to Santa Rosa. This potato became the foundation of Idaho's potato industry. He also developed an improved spineless cactus for livestock forage in desert regions.
* Nuts and Grains: Including hybrid walnuts and blight-resistant chestnuts.
* Ornamental Flowers: Hundreds of varieties, such as the Shasta daisy, the fire poppy, and new lilies.
His methods involved extensive cross-pollination, selective seed propagation, and grafting. He was known for his keen eye in selecting plants with the most promising characteristics.
Regarding a realistic virtual Earth for agriculture, gardens, and museums with a time slider like Google Street View:
While there isn't a single, universally available platform that precisely matches your description for all historical agricultural and botanical sites, here's a breakdown of what exists and what you're imagining:
* Google Street View: Offers realistic ground-level views of many locations, including some gardens and museums. However, it does not have a "time slider" that would show the evolution of a garden or agricultural field over historical periods like Burbank's time. The time slider in Street View typically shows different captures of the current street view over recent years, not historical eras.
* Virtual Tours of Gardens and Museums: Many institutions, like the Luther Burbank Home & Gardens in Santa Rosa, offer virtual tours (e.g., video tours, 360-degree photo tours, or audio tours). The Luther Burbank Home & Gardens specifically has a free cell phone audio tour that provides historical facts and highlights plants he introduced. While these are valuable, they generally present the current state of the gardens or curated historical information, not a dynamic, time-lapse "virtual Earth" of past agricultural practices.
* Specialized Platforms for Historical or Agricultural Data: There are academic or research-oriented platforms that might visualize historical land use or agricultural practices, but they are typically not designed for public, immersive "Street View" style exploration.
* The Concept You're Describing: A "realistic virtual Earth for agriculture, gardens, and museums with a time slider" is a fascinating and highly advanced concept. It would require immense amounts of historical geospatial data, detailed botanical records, architectural plans, and 3D modeling to accurately recreate environments and their evolution over time. While the technology for individual components (like 3D modeling and historical data visualization) exists, integrating it into a seamless, user-friendly, and comprehensive platform akin to Google Street View with historical time travel is a significant undertaking that hasn't been widely achieved yet for general public access across diverse sites.
In summary, while you can visit the Luther Burbank Home & Gardens in Santa Rosa in person or explore their current virtual offerings, a "Google Street View with time slider" for his historical plant breeding work as you envision is not currently available. It represents an exciting future possibility for digital historical preservation and education.
Greetings from MIT OCW-centric - https://ocw.mit.edu/ - wiki #GrowWithGoogleWUaS World Univ & Sch WUaS. Again, WUaS Monthly Business Meeting is becoming WUaS Weekly Business Meeting / WUaS News and Q&A on Mondays at 10 am PT as you may have read on Saturday, June 21, 2025.
As a Friendly unprogrammed Quaker (NtF, NtQ) leading or calling - to create free universal education with free-to-students' MIT OCW-centric World University and School WUaS Degrees in all ~200 countries and in their main languages, and free wiki schools for people-to-people wiki-teaching and wiki-leading in all 7,159 known living languages - WUaS Monthly Business Meeting (which has met on 3rd Saturdays at 9 am PT until now) is becoming WUaS Weekly Business Meeting / WUaS News and Q&A on Mondays at 10 am PT ... and this is what is guiding free MIT OCW-centric World University and School WUaS in so many ways.
In talking with a Quaker Friend recently, key next steps involve becoming accredited potentially with Middle States Commission on Higher Education with offices in the greater Philadelphia PA area (which involves having already matriculated students in part) - and to matriculate a large numbers of students for free-to-students' MIT OCW-centric WUaS degrees, online from home.
On the WUaS wiki side, it would be great to be generating large numbers of wiki teachings, and potentially for those people who might be interested in teaching about something they love in the future too & see agenda item 5 in last week's first WUaS Weekly Business Meeting here - https://scott-macleod.blogspot.com/2025/06/flame-skimmer-libellula-saturata.html.
The next MIT OCW-centric - https://ocw.mit.edu/ - wiki World Univ & Sch WUaS News and Q&A meets on Monday June 30, 2025 now again at 10:00 AM Pacific Time, 1:00 PM ET (US & Canada), 5:00 PM GMT, 10:30 PM India Time, 1:00 AM Tu the next day Hong Kong Time (but please check your time converter from any of your 24 time zones to join this open WUaS Monthly Business Meeting) with Zoom URL here too -
Free MIT OCW-centric wiki World Univ & Sch is growing, and growing with #GrowWithGoogleWUaS, for free-to-students' online degrees - Bachelor, PhD, Law, MD IB high school/similar, AA/AS, and Master's - first in English, then in each of all ~200 countries and in their main languages, and see Peter Norvig's INCREDIBLE #ToolifyAIWUaS "Revolutionizing Education with Machine Learning and AI: #WorldUniversityInSchool" - https://www.toolify.ai/ai-news/revolutionizing-education-with-machine-learning-and-ai-2574306.
All the best, abolition-ally, Friendly greetings, Scott
Monday, June 23, 2025 Flame Skimmer (Libellula saturata): Recording of the 6/23/25 @WorldUnivAndSch @WUaSPress #WUaSNewsQA #WUaSfaculty in India's 22 Languages #GeminiAcademy'& new WUaS Weekly Business Meeting * (was - A - M 06/23/25 open MIT OCW-centric wiki World Univ & Sch WUaS News and Q&A, with Zoom URL)
Recording of the 6/23/25 @WorldUnivAndSch @WUaSPress #WUaSNewsQA #WUaSfaculty in India's 22 Languages #GeminiAcademy'& new WUaS Weekly Business Meeting
AGI Accelerator at AGIhouse (on the Peninsula near Stanford University) ... and possibly for MIT OCW-centric wiki World University and School - Thanks, Roland Vogl, Stanford Law CodeX Executive Director
Tuesday, June 24, 2025 Red-wattled Lapwing (Vanellus indicus): An #ArtificialGeneralIntelligenceHouse, re #AGIhouse? (@WorldUnivAndSch Am EXCITED by new potential for an #AGIRealisticVirtualEarth & re #PeterNorvig's INCREDIBLE #ToolifyAIWUaS article - -re a #RealisticVirtualEarthForAGI to develop #AGIwuAs & #VirtualHarbin)
An #ArtificialGeneralIntelligenceHouse, re #AGIhouse? (@WorldUnivAndSch Am EXCITED by new potential for an #AGIRealisticVirtualEarth -re a #RealisticVirtualEarthForAGI to develop #AGIwuAs & #VirtualHarbin)
Twitter - George Church with Dwarkesh Patel interview June 2025 - "A Billion Years of Evolution in a Single Afternoon - . . ."
Many implications #FriendlyQuaker & #YogaWUaS -informed @WorldUnivAndSch @WUaSPress "A Billion Years of Evolution in a Single Afternoon — George Church" https://youtu.be/olmHHxFQwxo How to further dev #AgingReversal & #ExtremeLongevityGenetics in #RealisticVirtualEarth #ForLibraries?
AND Brainstorm: @geochurch w @dwarkesh_sp "A Cure for Aging by 2050? - George Church" https://youtu.be/N6WdeclE__w "A Billion Years of Evolution in a Single Afternoon -..." https://youtu.be/olmHHxFQwxo How to further dev #AgingReversal & #ExtremeLongevityGenetics in #RealisticVirtualEarth?
It's fantastic that you're looking to contribute to World University and School (WUaS)! Their model of leveraging open educational resources like MIT OCW and encouraging community contributions via a wiki is very forward-thinking, especially in the age of AGI.
Let's break down how you can best teach at WUaS and handle citations, drawing from their stated mission and the nature of a wiki.
How to Teach at World University and School (@WorldUnivAndSch)
Focus on explanation and clarity: Even if it's a non-traditional academic subject (like your "Gray-Headed Swamphen" example), the goal is to educate. Explain concepts clearly, break down complex ideas, and provide context.
Show, don't just tell: For practical subjects (e.g., cooking, art techniques, birdwatching identification), videos are perfect for demonstrations.
Connect to broader knowledge (if possible): Can your passion topic be linked to scientific principles (e.g., bird migration to biology, cooking to chemistry), history, or culture? This adds academic depth.
Audience: Think about who would be interested in learning about this. Are you aiming for beginners, enthusiasts, or a more specialized audience?
Align with MIT OCW (where applicable): If you're teaching a subject covered by MIT OCW, consider how your video complements or extends those materials. You could provide:
Alternative explanations of complex topics.
Solved problems or worked examples.
Real-world applications or case studies.
Summaries or reviews of OCW modules.
Discussions of current research or recent developments in the field.
Structure for learning: Design your video as a mini-lesson. Have clear learning objectives for each video.
Build a series: For more complex academic subjects, consider a series of short videos on related topics. This creates a more comprehensive learning path.
Demonstrate pedagogical skills: Use clear communication, effective visuals, engage with potential questions (even if hypothetical), and summarize key points. This helps build your "online teaching experience" portfolio.
2. Create Your YouTube Video(s):
Quality Matters:
Audio: Clear, crisp audio is paramount. Invest in a decent microphone if you can.
Video: Good lighting, stable camera, and clear visuals (slides, whiteboard, demonstrations) are essential.
Conciseness: Aim for focused videos, ideally under 10-15 minutes for individual concepts. Longer videos can be broken down.
Engagement: Speak clearly, vary your tone, use visuals effectively, and maintain eye contact (if on camera).
Content Considerations for WUaS:
Open License: Ensure your video content is open for educational use. While YouTube generally has its own terms, WUaS's mission implies content that can be freely accessed and used for learning.
No Paywall/Ads (ideally): For a free educational platform, linking to videos with excessive or disruptive ads might be less ideal.
If not, consider creating a new page for it. Follow existing naming conventions and categorization.
Edit the Wiki Page:
Look for the "Edit" tab at the top of the page.
Wikis typically use a simplified markup language (like MediaWiki, similar to Wikipedia).
Embedding YouTube: The most common way is using a specific tag or template. For MediaWiki, it's often {{#ev:youtube|VIDEO_ID}} or similar, where VIDEO_ID is the unique part of the YouTube URL (e.g., for youtube.com/watch?v=dQw4w9WgXcQ, the ID is dQw4w9WgXcQ). The exact syntax might be on their FAQ or by looking at how other videos are embedded.
Add Context and Structure:
Introduction: Briefly explain what your video is about and its relevance to the subject.
Learning Objectives: What will a viewer learn from this video?
Summary/Key Points: Briefly summarize the main takeaways.
Pre-requisites/Next Steps: Suggest what a learner should know before watching or what they could explore afterward.
Related Resources: Link to relevant MIT OCW courses, other WUaS wiki pages, external articles, or books.
Discussion Prompts: Encourage interaction by posing questions for learners to consider or discuss.
Categorization: Ensure the wiki page is correctly categorized so it appears under relevant subject headings.
4. Gaining Online Teaching Experience through WUaS:
Portfolio Building: Every video and wiki contribution you make is a demonstrable piece of your online teaching experience.
Feedback: Engage with any comments or edits on your wiki pages. This shows your ability to adapt and collaborate.
Refinement: Use the experience to refine your teaching style, video production, and content structuring.
Networking (Indirect): While direct networking might be limited, your contributions are public and showcase your expertise to anyone visiting WUaS.
Accreditation (Future): WUaS has a long-term goal of accreditation. Contributing now aligns you with that vision and puts you in a good position if they develop more formal "instructor" roles in the future.
Citation Format for WUaS Wiki
The World University and School wiki, being a wiki, likely follows a flexible but consistent approach to citations, similar to Wikipedia. Looking at their FAQ (https://wiki.worlduniversityandschool.org/wiki/Frequently_Asked_Questions) and other wiki pages would be your best bet, but generally:
No specific, rigid style is usually enforced across all content. However, the principle is to provide enough information for others to verify the source.
Inline citations are key. This means immediately after the fact, quote, or idea you're citing, you'll place a reference.
A "References" or "Bibliography" section at the end of the page. This lists the full details of all sources cited in the text.
General Guidelines (assuming a Wikipedia-like MediaWiki environment):
Use <ref> tags for inline citations:
To cite something in the text, you'd typically enclose the citation information within <ref> and </ref> tags.
Example: "The Gray-Headed Swamphen is known for its vibrant plumage."
At the bottom of the page, include a <references/> tag (or {{reflist}} if they use that template) to automatically generate the list of references.
What information to include for different source types:
Your own YouTube Video:
Your Name (or Channel Name). "Video Title." YouTube, Date Uploaded, URL.
Consistency: While a specific style might not be mandated, try to be consistent with the elements you include for each type of source.
Clarity: Make it easy for someone else to find your source.
Avoid self-promotion (beyond educational content): While you're teaching, focus the content on the subject matter, not on promoting your personal brand outside the educational context.
By following these guidelines, you can effectively contribute to World University and School, share your knowledge, gain valuable online teaching experience, and properly attribute your sources within their open wiki environment.
AND ...
and asked Gemini AI further in voice -
How with artificial general intelligence further and to inspire people to teach at MIT opencourseware Centric Wiki World University and school can I share with people how do I teach at World University in school about what I love or for online teaching experience etcetera and what citation format do I use for adding what I teach or a resource to the World University and School ?
It's exciting that you're interested in contributing to World University and School (WUaS) and leveraging the power of MIT OpenCourseWare! Here's a breakdown of how to approach your questions:
How Artificial General Intelligence (AGI) Can Further and Inspire Teaching at WUaS
AGI has the potential to revolutionize open education at WUaS in several ways:
Personalized Learning Paths: AGI could analyze a student's learning style, prior knowledge, and goals to create highly customized learning paths, drawing from the vast resources of MIT OCW and other open educational resources (OER). This would make learning more efficient and engaging.
Intelligent Tutoring Systems: AGI-powered tutors could provide instant feedback, answer questions, and offer explanations in various subjects, acting as a tireless and accessible resource for students worldwide.
Automated Content Creation and Curation: AGI could assist in identifying, organizing, and even generating new educational content, making it easier for educators at WUaS to create comprehensive courses and wikis. This could include summarizing complex topics, creating practice problems, or even generating new perspectives on existing materials.
Global Collaboration and Translation: AGI can facilitate seamless communication and collaboration among students and educators from different linguistic backgrounds, automatically translating resources and discussions. This is particularly relevant for WUaS's goal of reaching all 7,000+ languages.
Enhanced Accessibility: AGI can adapt educational materials for diverse learners, including those with disabilities, by automatically generating captions, audio descriptions, and alternative formats.
Data-Driven Insights: AGI can analyze learning data to identify areas where students struggle, allowing WUaS to continuously improve its courses and teaching methodologies.
AGI's ability to automate tedious tasks, personalize learning, and bridge communication gaps could significantly inspire more people to teach and learn at WUaS by making the process more efficient, accessible, and impactful.
Dear William / Bill Kelly (Vicki Nash whom I met at Harvard Law Emeritus Professor Charlie Nesson's home in Cambridge MA in around 2006 at a brunch at a celebration for the Berkman Center of Internet and Society at Harvard Law School, Dean MacCannell whom I know from the UC Berkeley Tourism Studies' Working Group in the Anthropology department there and see PPPS, MediaAnthro), All,
Dear William / Bill Kelly (Vicki Nash whom I met at Harvard Law Emeritus Professor Charlie Nesson's home in Cambridge MA in around 2006 at a brunch at a celebration for the Berkman Center of Internet and Society at Harvard Law School, Dean MacCannell whom I know from the UC Berkeley Tourism Studies' Working Group in the Anthropology department there and see PPPS, MediaAnthro), All,
Thanks for this information about an Oxford "Digital Ethnography" course beginning soon - https://www.conted.ox.ac.uk/courses/digital-ethnography. And greetings from near Harbin Hot Springs' Heart Consciousness Church, my physical-digital ethnographic field site, and for my next Harbin Hot Springs' ethnographic book project, to be developed for research in something like Google Street View with time slider, and also for publishing (both to 1) Paper, and 2) to new digital formats such as the the back of digital glasses, and in #WUaSMultimediaRooms even, thus potentially reinventing the book even). As founder and president of MIT OCW-centric wiki #GrowWithGoogleWUaS World University and School for free-to-students' online WUaS degrees from home in each of all ~200 countries and in their main languages, WUaS seeks to further develop a #RealisticVirtualEarth #ForEverything (including #ForSTEM #ForEthnography - #ForMuseums & #ForLibraries, all, ever in all languages ever - and #ForArchaeology #ForPaleontology, and a #RealisticVirtualEarthForHistory with #GTimeSlider ... and see #Twitter and #LinkedIN for these #hashtags) as classrooms and field sites too, and see Peter Norvig's INCREDIBLE #ToolifyAIWUaS article - https://www.toolify.ai/ai-news/revolutionizing-education-with-machine-learning-and-ai-2574306 - mentioning a virtual Harbin for the first time ever (other than by me and MIT OCW-centric wiki World University and School of which again I'm the founder and head), and also to study bliss in virtual Harbin (and search on these words). Bill, since you went to the University of California, Davis, have you ever visited Harbin Hot Springs' Heart Consciousness Church?
Agenda item 5
What did Luther Burbank do in Santa Rosa & Sebastopol with plant breeding, and when?
What did #LutherBurbank do in Santa Rosa & Sebastopol w #PlantBreeding & from when to when & can I see this in a #RealisticVirtualEarthForAgriculture a #RealisticVirtualEarth #ForGardens #ForNuseums & think #GStreetView w #GTimeSlider @WorldUnivAndSch? https://g.co/gemini/share/05c5a5acac51 ~
AND - What did Luther Burbank do in Santa Rosa & Sebastopol with plant breeding and from what year to what year and can I see this in a realistic virtual Earth for agriculture, a realistic virtual Earth for Gardens and museums and think Google Street View with time slider at this point?
How best to interoperate in a #RealisticVirtualEarthForGenetics the best #FilmTo3DApps - re microscopy & electron microscopy - @ molecule & cell levels that scientists are using for #AgingReversal #ExtremeLongevity gene Research @WorldUnivAndSch? Gemini: https://g.co/gemini/share/a8cf3a93b7c3 ~
How best to interoperate in a #RealisticVirtualEarthForGenetics the best #FilmTo3DApps - re microscopy & electron microscopy - @ molecule & cell levels that scientists are using for #AgingReversal #ExtremeLongevity gene Research @WorldUnivAndSch? Gemini: https://g.co/gemini/share/7ed0acf798cd ~
grow @WorldUnivAndSch w free #WUaSDegrees in a #RealisticVirtualEarth & for #AcademicPublishing @WUaSPress to 1) paper & 2) brand new digital formats?
How best can free-to-students' #MITOCW-centric (in 5 langs now) grow @WorldUnivAndSch w free #WUaSDegrees in a #RealisticVirtualEarth in #GStreetView w #GTimeSlider as classrooms & #STEAMfieldsites & for #AcademicPublishing @WUaSPress to 1) paper & 2) brand new digital formats?
grow @WorldUnivAndSch w free #WUaSDegrees in a #RealisticVirtualEarth & for #AcademicPublishing @WUaSPress to 1) paper & 2) brand new digital formats?
How best can free-to-students' #MITOCW-centric (in 5 langs now) grow @WorldUnivAndSch w free #WUaSDegrees in a #RealisticVirtualEarth in #GStreetView w #GTimeSlider as classrooms & #STEAMfieldsites & for #AcademicPublishing @WUaSPress to 1) paper & 2) brand new digital formats?
What #AcademicBooks have been written & published with #XTwitter or #Twitter posts as kinds of paragraphs, If any? Were these possible books published & printed to both paper & digital formats? What did doing so do in the book? Concision, bring in a social media conversation...?
What academic books have been written & published with #XTwitter or #Twitter posts as kinds of paragraphs, If any? Were these possible books published & printed to both paper & digital formats? What did doing so do in the book? Concision, bring in a social media conversation...?
Yes, there are academic books that utilize or discuss X/Twitter posts (formerly Twitter) as part of their content or analysis. Books that analyze X/Twitter as data or subject matter:
https://opencw.aprende.org/courses/translated-courses/ - centric with 'the state' (#USFederalGovt, #USStates, #NationStatesGovts) beyo #WorldUniversityINSchool @WorldUnivAndSch @WUaSPress in #GrowWithGoogleWUaS program & w own #ArtificialGeneralIntelligenceWUaS in 7159 #LivingLanguages?
@WorldUnivAndSch @WUaSPress in #GrowWithGoogleWUaS program & w own #ArtificialGeneralIntelligenceWUaS in 7159 #LivingLanguages, how to interoperate w 'the state' (#USFederalGovt, #USStates, #NationStatesGovts) beyo #WorldUniversityINSchool?
@WorldUnivAndSch @WUaSPress in #GrowWithGoogleWUaS program & w own #ArtificialGeneralIntelligenceWUaS in 7159 #LivingLanguages, how to interoperate w 'the state' (#USFederalGovt, #USStates, #NationStatesGovts) beyo #WorldUniversityINSchool?
Great: #AdventuresInAI #ExploreQuestionPlay exhibit! @ #ExploratoriumSF - https://www.exploratorium.edu/visit/calendar/ai In MITOCW-centric wiki @WorldUnivAndSch facilitating a #RealisticVirtualEarthForMuseums, all, ever, (think #GStreetView w #TimeSlider - https://www.google.com/maps/place/exploratorium+sf/data=!4m2!3m1!1s0x808586d4e4e56b93:0xb239bfbb3aff1c0?sa=X&ved=1t:155783&ictx=111) & to which we can all #WikiAdd, & via #EthnoWikiVirtualWorldGraphy & in writing Ch. 10 in #SocInfoTechAndTheGlobalUniv upcoming book on a #RealisticVirtualEarth #ForMuseums @WUaSPress how would this work further for you or I learning about & playing with AI in a #VirtualExploratorium & for #FutureResearchWUaS - with parallels to the #ExploratoriumIsland in the #3DGroupBuildable #VirtualWorld of #SecondLife?
*
In @W facilitating a #RealisticVirtualEarthForMuseums, all, ever, & to which we can all wiki-add resources, & in writing Ch. 10 in #SocInfoTechAndTheGlobalUniv upcoming book on a #RealisticVirtualEarth ForMuseums @W
- and this time I took some notes and am asking some questions that come to mind ... and in learning the language of genetics (from a practical family identity biology perspective) - genealogy genetics - and in seeking to understand your thinking especially. (And how could we eventually represent the data and questions you cover in new ways in a realistic virtual earth for genealogy and genetics?). (Am recalling that all people share ~50% of their genetic material with each of their parents, about 25% with their grandparents, and see PS ... And as I've mentioned to you before, I enjoy seeing 'who came before' in genealogy platforms online ... and learning about them with genealogy software / platforms / trees ... and regarding construing your questions possibly in a different way. And could I see your Ancestry .com family tree to go back from our great great great grandfather Norman John MacLeod, for whom there's some documentary evidence, to Leod in one way or another, and add some of this to https://www.wikitree.com/wiki/MacLeod-2524 ? ... And with Ancestry .com's new updated genetics' email (Your AncestryDNA Results have been updated
"You have 1 new journey.
Ancestral journeys reveal where your ancestors may have lived over the past 300 years and why they may have moved—
Are you asking can we extrapolate every MacLeod's genetics in the first group you identify - and I'd be interested to see the genetic data for this in another possible great MacLeod DNA video you make (i.e. with the last name MacLeod, and the genetics for those we don't have names, documents, or otherwise biographical or genealogy evidence for) - to trace them back to Leòd, as in he's the ~20th (or 25th or whatever the number) great grandfather of each and everyone with the last name MacLeod in the first group or similar? And I wonder too if you're engaging in a form of scientism or social constructionism regarding 'here are the Clan Macleod family history narratives, construed by you as The DNA of Clan MacLeod, and here's a scientistic window into reading the genetics from a genealogy genetics' perspective'. What do you think? I found your talk very compelling and fascinating. Thank you.
(My initial related question genetically somehow is - How are people all with the last name MacLeod in my and your genetic lines related genetically, and how can we see this with current genealogy genetic tests and on current genealogy platforms - not yet whole genome sequencing - and how do we navigate and represent on online genealogy tree platforms the ancestors we have no biographical data for, but for whom we do have extrapolatable genetic data?
2:00
"All of MacLeod men today can be placed into 1 of 5 distinct genetic groups ..."
I'd be interested further in seeing some of this actual data perhaps at some point ... appreciating your broad introduction into genetics (with the practical lens of family genealogy and a quite coherent MacLeod DNA identify genetic narrative) ...
How to make all the data you draw on accessible in an open source manner such that scientists and geneticists - and genetic genealogists - could further develop your great thinking - AND in a #RealisticVirtualEarthForGenealogy (https://x.com/scottmacleod/status/1407796864662003716)?
I'll have a look again at
The DNA of Clan MacLeod (2025) By Mark K. MacLeod1, Colin Macleod and Roderick A. F. MacLeod WWW: Journal of Genetic Genealogy
~50% of their genetic material with each of their parents
25% with their grandparents
12.5 % with great grandparents
6.25 % with great great grandparents
3.125 % with great great great grandparents
how much does an individual share with each of the next 10 generations?
Asked Gemini AI and found out -
Here's how much genetic material is shared with each of the next 10 generations, continuing the halving pattern:
Great-great-great-great grandparents (1st next generation): 3.125%/2=1.5625%
Great-great-great-great-great grandparents (2nd next generation): 1.5625%/2=0.78125%
Great-great-great-great-great-great grandparents (3rd next generation): 0.78125%/2=0.390625%
Great-great-great-great-great-great-great grandparents (4th next generation): 0.390625%/2=0.1953125%
Great-great-great-great-great-great-great-great grandparents (5th next generation): 0.1953125%/2=0.09765625%
Great-great-great-great-great-great-great-great-great grandparents (6th next generation): 0.09765625%/2=0.048828125%
Great-great-great-great-great-great-great-great-great-great grandparents (7th next generation): 0.048828125%/2=0.0244140625%
Great-great-great-great-great-great-great-great-great-great-great grandparents (8th next generation): 0.0244140625%/2=0.01220703125%
Great-great-great-great-great-great-great-great-great-great-great-great grandparents (9th next generation): 0.01220703125%/2=0.006103515625%
Great-great-great-great-great-great-great-great-great-great-great-great-great grandparents (10th next generation): 0.006103515625%/2=0.0030517578125%
It's important to note that these percentages represent theoretical averages. Due to the random nature of genetic recombination, the actual amount of shared DNA with any specific ancestor can vary slightly.
1.5625% with great-great-great-great grandparents (who is?)
0.78125% with great-great-great-great-great grandparents
0.390625% with great-great-great-great-great-great grandparents
0.1953125% with great-great-great-great-great-great-great grandparents
0.09765625% with Great-great-great-great-great-great-great-great grandparents
0.048828125% with Great-great-great-great-great-great-great-great-great grandparents
0.01220703125% with Great-great-great-great-great-great-great-great-great-great-great grandparents
0.006103515625% with Great-great-great-great-great-great-great-great-great-great-great-great grandparents
PPPS
How best to develop #GenealogyResearchWU in a new direction in a #RealisticVirtualEarth, #RealisticVirtualEarthForGenealogy, #RealisticVirtualEarthForHistory, a #RealisticVirtualEarthForGenetics & re #AgingReversalGenetics & #ExtremeLongevityGenetics, w related #GeneTherapies coming?
Roots in #VintonIA #DesMoinesIA How could I #ScottGKMacLeod talk virtually with my mother's Pa #SandyBrown #AlexanderChadbourneBrown & #ChadbourneAncestors #wuAsVR #WUaSAR? #REALISTICVIRTUALEARTHFORHISTORY in #GoogleStreetView w #TimeSlider & for #REALISTICVIRTUALEARTHForGenealogy?
#ClanMacLeod Parliament is in full swing now with over 300 delegates attending the week's full programme of events. The pic shows the first Clan Parliament in 1956. The gathering of MacLeods from all over the globe was an idea of Dame Flora MacLeod, the 28th Chief of the Clan.
How is whole genome sequencing of ancestors in genealogy done, if at all?
Whole genome sequencing (WGS) in genealogy involves analyzing an individual's entire DNA sequence to understand their ancestry and potentially identify relatives, though it's not the primary tool used in most consumer-grade genealogy testing. While traditional genealogy relies on autosomal DNA, WGS offers a more comprehensive view of the genome, including non-coding regions and rare variants, which can be valuable for tracing deep ancestry and identifying distant relatives.
Here's how it works and its role in genealogy:
1. DNA Extraction and Sequencing:
A DNA sample (usually blood or saliva) is taken from an individual.
The DNA is extracted, purified, and then sequenced using specialized machines that read the order of all base pairs (A, T, C, and G) in the genome.
This process, known as whole genome shotgun sequencing, breaks the DNA into smaller fragments, sequences them, and then reassembles them to create a complete DNA sequence.
2. Data Analysis and Interpretation:
The raw DNA data is then analyzed using bioinformatics pipelines to identify genetic variants and compare them to reference genomes.
This analysis can reveal information about ancestry, including ethnic origins and potential connections to other individuals who have also been sequenced.
While WGS can be used for traditional genealogical research, it's more commonly used in genetic genealogy to identify distant relatives, uncover deeper ancestral lineages, and solve cold cases where traditional methods have failed.
(like those offered by 23andMe, AncestryDNA, and MyHeritage) typically analyze specific regions of the genome (like SNPs) to estimate ethnicity and identify close relatives.
provides the most comprehensive view of the genome, including non-coding regions and rare variants, which can be particularly useful for tracing deep ancestry and identifying distant relatives.
WGS can be valuable for identifying distant relatives by analyzing shared DNA segments, even those that are small and rare.
It can be used to break through "brick walls" in family trees by identifying previously unknown connections and tracing lineages back further in time.
WGS data can be used in conjunction with traditional genealogy methods to build more complete and accurate family trees.
5. Challenges and Considerations:
Cost: WGS is significantly more expensive than other DNA tests.
Data Storage and Interpretation: WGS generates a large amount of data that requires specialized expertise for analysis and interpretation.
Privacy: WGS data can reveal sensitive information about health and ancestry, so it's crucial to consider privacy and data security.
In conclusion, while WGS is not the primary tool used in most genealogy testing, it offers a powerful approach for understanding deep ancestry and identifying distant relatives due to its comprehensive analysis of the genome
PPPPS
Julia Abernethy ucl macleod genetic study linkedin
In a related vein, I just shared this with you and my mother, Jane, Sid/Pin (Mazumdar in HHS in the US federal govt & best friend from high school), and best friend in the SF Bay Area Ed (Smyth MD) -
"Hi Ed, Ma, Pin, ... How are you? Greetings! Thanks Ed for precipitating my moving into a newly safe 670 Ridgecrest Road, and with WUaS PO Box 442, Canyon 94516 mail too ... and I can hypothesize that the investigation into the culture of criminality and international organized crime in the greater SF Bay Area, and individuals too, back decades even ... may be unfolding further since I first drove west from asylum in Pgh on 12/10/24 ... Just emailed my cousin Mark Macleod in Portland Maine further (and as a Stanford alum, and possibly a US general re the Oil industry per LinkedIn, and having lived in Scotland too and being deeply interested in genealogy genetic) ... re my ongoing seeking to move into a newly safe Canyon 94516 ... and beginning a family -
Will read your paper further ... and re #TextInTheSidebar of a #RealisticVirtualEarthForGenealogy #RealisticVirtualEarthForGenetics ... and could Dave Vance and Rob Spencer even help with this, potentially with Peter Norvig and Google too?
And how to connect potentially with Donna Leet MD I wonder? (And might we move in together to a newly safe open 670 Ridgecrest Rd, Canyon 94516, where I lived for about 13 years until calling the local police twice at Stanford alum too Cindy, and Byron, Hann MDs encouragement {who lived together in Scotland for 3 years, and where Byron's step-brother may be stationed in Scotland as part of the US federal government even} from nearby Moraga CA)?
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Will read your paper further ... and re #TextInTheSidebar of a #RealisticVirtualEarthForGenealogy #RealisticVirtualEarthForGenetics ... and could Dave Vance and Rob Spencer even help with this, potentially with Peter Norvig and Google too?
And how to connect potentially with Donna Leet MD I wonder? (And might we move in together to a newly safe open 670 Ridgecrest Rd, Canyon 94516, where I lived for about 13 years until calling the local police twice at Stanford alum too Cindy, and Byron, Hann MDs encouragement, from nearby Moraga CA)?
Are you suggesting or proposing or hypothesizing a north of Scotland Leod MacLeod gene (since ~1300) - eg SNP BY3210 and related ones - (and if so, a further question comes to mind ... how prevalent are the SNP BY3210 and related genes in your paper ... in the rest of the 7.9 billion people in the planet ) ?
A further sociological social science anthropological thought comes to mind regarding social constructionism.
Social constructionism is a theory suggesting that many aspects of our world, including knowledge and reality, are not objective truths but are created and shaped by social interactions and cultural contexts. It argues that shared understandings, language, and cultural practices play a crucial role in defining and maintaining these constructs.
... and regarding the terms, language, names, concepts you're operatioinalizing regarding genetics.
Fascinating and thank you for sharing your excellent paper -
The DNA of Clan MacLeod (2025) By Mark K. MacLeod1, Colin Macleod and Roderick A. F. MacLeod WWW: Journal of Genetic Genealogy
And happy birthday further! Sounds like you had a good birthday celebration.
Identity (anthropology and sociology-wise) and troopbondage (http://scottmacleod.com/JohnMoneyConceptsOfDeterminism.html) come to mind in reading your paper and regarding connecting a name to genes through time (big-picture-wise) ... And I'd like to iteratively make it possible to examine such (your) terms, categories, concepts and names in your paper ... in an unfolding genetic science conversation ... and in a #RealisticVirtualEarthForGenealogy (and in thinking Google Street View with time slider +). Thanks for all the great maps with genetic trajectories in your paper too, #TextInTheSidebar.
After emailing you yesterday, I created this set of Tweets and 2 related LinkedIN posts (with useful #Hashtags, but not yet cross-platform that I know of) too in some of these regards -
How best to dev #GenealogyResearchWU in a new direction in a #RealisticVirtualEarth, #RealisticVirtualEarthForGenealogy, #RealisticVirtualEarthForHistory, a #RealisticVirtualEarthForGenetics & re #AgingReversalGenetics & #ExtremeLongevityGenetics, w related #GeneTherapies coming?
#ClanMacLeod Parliament is in full swing now with over 300 delegates attending the week's full programme of events. The pic shows the first Clan Parliament in 1956. The gathering of MacLeods from all over the globe was an idea of Dame Flora MacLeod, the 28th Chief of the Clan.
retweeting both where my Grandfather "Sandy" Alexander Chadbourne Brown had some roots in Vinton Iowa, briefly, between being born in Boulder, CO, and going to Exeter and then MIT for school, as well as retweeting a picture of the MacLeod parliament.
Time to check out further -
Mark K. MacLeod. 2023
The DNA of Clan MacLeod: Is Leòd our common ancestor?
How best to develop #GenealogyResearchWU @ #MITOCW-centric wiki #WorldUniversityAndSchool in a new direction in a #RealisticVirtualEarth, #RealisticVirtualEarthForGenealogy, #RealisticVirtualEarthForHistory, a #RealisticVirtualEarthForGenetics ? ...
How best to dev #GenealogyResearchWU in a new direction in a #RealisticVirtualEarth, #RealisticVirtualEarthForGenealogy, #RealisticVirtualEarthForHistory, a #RealisticVirtualEarthForGenetics & re #AgingReversalGenetics & #ExtremeLongevityGenetics, w related #GeneTherapies coming?
Roots in #VintonIA #DesMoinesIA How could I #ScottGKMacLeod talk virtually with my mother's Pa #SandyBrown #AlexanderChadbourneBrown & #ChadbourneAncestors #wuAsVR #WUaSAR? #REALISTICVIRTUALEARTHFORHISTORY in #GoogleStreetView w #TimeSlider & for #REALISTICVIRTUALEARTHForGenealogy?
#ClanMacLeod Parliament is in full swing now with over 300 delegates attending the week's full programme of events. The pic shows the first Clan Parliament in 1956. The gathering of MacLeods from all over the globe was an idea of Dame Flora MacLeod, the 28th Chief of the Clan.
How best to dev #GenealogyResearchWU in a new direction in a #RealisticVirtualEarth, #RealisticVirtualEarthForGenealogy, #RealisticVirtualEarthForHistory, a #RealisticVirtualEarthForGenetics & re #AgingReversalGenetics & #ExtremeLongevityGenetics, w related gene therapies coming?
How much are you in communication with Rob Spencer in CT, whose MIT and Pfizer background seem potentially very helpful re developments in genetic genealogy (and especially regarding a #RealisticVirtualEarthForGenealogy)?
Happy Birthday from your 1st cousin in Middletown, CA not that far away from "Harbin Hot Springs - Heart Consciousness Church!" How are you doing? And how are you celebrating? How is your genealogy research going? (And how best to develop genealogy research in a brand new direction in a #RealisticVirtualEarth a #RealisticVirtualEarthForGeneaology, a #RealisticVirtualEarthForHistory, and a #RealisticVirtualEarthForGenetics ... and even regarding emerging aging reversal genetics and extreme longevity genetics, with related drug therapies potentially emerging ?)
Are you still 'mining' Ancestry .com for its genealogy treasures - and even sharing the following Ancestry emails occasionally (in the pS, that just came into my sgkmacleod@gmail.com email box :)?
In 1975, Chantal Doecke was separated from her twin as part of Operation Babylift, a controversial evacuation effort from South Vietnam. Now, you can watch their emotional first meeting in this heartwarming documentary.
Mother’s Day has come and gone, but why not keep that energy going? We partnered with Ms. Tina Knowles to help launch Matriarch, her revealing new memoir about growing up, being a mother, and changing the world. Dig into her story, then uncover your own.
To commemorate the 80th anniversary of V‑E Day, see how newspapers around the world reported the Allied victory in Europe, and imagine your ancestors reading the same articles as the news broke.
Dear All, Byron & Cindy, Donna, Ed, (ABCDE), Drs., (Byron & Cindy (Hann MDs), Ed (Smyth MD, Kaiser Permanente NorCal, I think)), Pin/Sid (Mazumdar HHS), Peter (Norvig, Google AI), George (Church, Harvard Med Sch), US Senator Alex Padilla from CA, Lt. John (Tadler, Allegheny County Police in Pgh, and re FBI workshop in 2013), US Senator from MA and former Harvard Law Professor Elizabeth Warren),
"Benjamin Lincoln accepted the sword of surrender from the British on October 19, 1781, at Yorktown, Virginia, during the surrender ceremony that formally ended the Siege of Yorktown and the American Revolutionary War's major land battles. While General Cornwallis did not personally surrender, he sent his second-in-command, General Charles O'Hara, to surrender to Lincoln, who represented General Washington"
His name is on a plaque in front of the Unitarian Universalist Church in Concord MA ... and he lived in Hingham MA which home I visited October 11, 2024 (and here are 3 photos - https://photos.app.goo.gl/PudQ5HMpWsdofbEC9 ) ...
Are #WholeGenomeSequencing #WGS & -#GeneticGenealogy AND -#ExtremeLongevity & #AgingReversal #GeneticDrugTherapies ahead -in a #RealisticVirtualEarthForGenomics ...?
04 June 2021 A complete human genome sequence is close: how scientists filled in the gaps Researchers added 200 million DNA base pairs and 115 protein-coding genes — but they’ve yet to entirely sequence the Y chromosome. By Sara Reardon
whole genome sequencing and extreme longevity & aging reversal genetic drug therapies - is this ahead?
Yes, whole-genome sequencing (WGS) and genetic drug therapies related to aging reversal and extreme longevity are promising areas of research that are actively advancing, with the potential for significant future breakthroughs.
WGS provides insights into rare genetic variants associated with healthy aging and extreme longevity (EL).
Studying individuals with extreme longevity, such as centenarians and semi-supercentenarians, allows researchers to assess the impact of genetic variability on this trait.
WGS can lead to the identification of key genes and pathways that contribute to human longevity and healthy aging.
Advances in sequencing technologies have made WGS more accessible and affordable, enabling widespread adoption in research and potentially in clinical settings for rare genetic disorders.
2. Aging Reversal and Genetic Drug Therapies:
Genetic therapies have been shown to extend lifespan and reduce age-related deficits in model organisms like mice, for example, by utilizing genetic reprogramming.
Studies have demonstrated the potential to reverse cellular aging without causing cells to become cancerous, opening avenues for therapeutic interventions.
Chemical approaches to reprogramming cells to a younger state are being explored, offering a potential alternative to gene therapy.
Partial cellular reprogramming has shown promise in extending lifespan in mice, potentially paving the way for clinical applications.
Numerous companies are actively developing gene therapies and other aging therapeutics.
3. Specific Examples of Progress:
Researchers using WGS data identified a longevity-associated variant in the SLC9A2 gene, which was linked to reduced hypertension risk and potentially increased cancer risk.
A promising gene therapy intervention involving Yamanaka factors extended the remaining lifespan of very old mice.
Harvard scientists have identified a chemical drug cocktail that may reverse aging.
Researchers have identified more than 100 genes associated with rejuvenation mechanisms.
4. Looking Ahead:
Continued research utilizing WGS and advanced genetic technologies is crucial for understanding the complex mechanisms of aging.
Developing therapies based on these findings holds potential for treating age-related diseases, improving healthspan, and potentially extending lifespan.
However, it's important to acknowledge that the field is still in its early stages, and there are significant challenges to overcome before these therapies are widely available to humans.
In summary, while aging reversal and extreme longevity through genetic drug therapies are not yet a widespread reality, the rapid advancements in WGS technology and the encouraging results from research in model organisms and initial human studies suggest that these approaches hold tremendous potential and are on the horizon. Ethical considerations, safety concerns, and the need for further research and clinical trials are vital aspects to address in the development and implementation of these groundbreaking therapies
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whole genome sequencing and genetic genealogy - is this ahead?
Whole-genome sequencing (WGS) is advancing rapidly and holds significant promise for genetic genealogy, particularly in providing a much more comprehensive view of an individual's ancestry compared to current standard methods.
Here's why WGS is considered to be "ahead" or the future of genetic genealogy:
Comprehensive Data: WGS analyzes the entire genome, including both coding and noncoding regions, offering a complete picture of an individual's genetic makeup. This provides a higher resolution and allows for the identification of a wider range of genetic variations relevant to tracing ancestry and understanding population history.
Overcoming Limitations of Current Methods: Current ancestry tests, primarily based on single nucleotide polymorphisms (SNPs), analyze only a fraction of the genome. WGS overcomes this limitation by capturing all genetic information, including larger structural variations and regions that are difficult to analyze with SNP-based tests, leading to more detailed and accurate genealogical insights.
Cost Reduction: The cost of WGS has decreased dramatically, making it more accessible for genealogical research. Some technologies are even approaching the $100 mark when performed at scale.
Improved Accuracy: WGS offers a higher resolution and more accurate identification of genetic variants compared to traditional methods. This allows for the tracing of ancestral lineages with greater precision.
Potential for Integration: WGS data can be combined with traditional genealogical research and other "omics" data (like transcriptomics and epigenomics) to create a more comprehensive understanding of family history.
However, it's important to acknowledge that there are still some challenges to address:
Data Interpretation: WGS generates a large amount of complex data that requires extensive analysis and interpretation by specialists.
Privacy Concerns: The comprehensive nature of WGS raises concerns about data privacy and the potential for misuse of genetic information.
Lack of Understanding: General public understanding of genetics and the ethical issues involved in WGS is still developing.
Despite these challenges, the continued advancements in technology and decreasing costs suggest that WGS is becoming increasingly important and is likely to become the standard for genetic genealogy in the future
Further envisioning for WUaS and re home robotics, and Donating to #Unitarian Universalist Church & #Quaker Meeting ~
Next for #FreeToStudents' #MITOCW-centric wiki #GrowWithGoogleWUaS @WorldUnivAndSch for online #WUaSdegrees from home in ~200 countries in #RealisticVirtualEarth? How & where to open 1st #PhysicalDigital #WUaSEducationalServicesStores @WUaSPress for outreach? #WUaSAccreditation -
12/2023-1/2024 @WorldUnivAndSch #WUaSLegoRobotics & for free #MITOCW-centric wiki #freeWUaSdegrees, a flagship #PhysicalDigital large #WUaSEducationalServicesStores in recently closed Walmart in #WaterworksMall #PghPA Donating to #Unitarian Universalist Church & #Quaker Meeting ~
Next for #FreeToStudents' #MITOCW-centric wiki #GrowWithGoogleWUaS @WorldUnivAndSch for online #WUaSdegrees from home in ~200 countries in #RealisticVirtualEarth? How & where to open 1st #PhysicalDigital #WUaSEducationalServicesStores @WUaSPress for outreach? #WUaSAccreditation ~
Looking forward @WorldUnivAndSch "Like CC-4 #MITOCWOpenCourseWare with Wikipedia aka World Univ & Sch | Canyon, CA | Contributions tax deductible info as of June 2025" To when GuideStar affiliated with the IRS builds its new #DataPlatform -https://www.guidestar.org/profile/27-3105368 &re @WUaSPress ~
Further envisioning for WUaS and re home robotics, and Donating to #Unitarian Universalist Church & #Quaker Meeting ~
Next for #FreeToStudents' #MITOCW-centric wiki #GrowWithGoogleWUaS @WorldUnivAndSch for online #WUaSdegrees from home in ~200 countries in #RealisticVirtualEarth? How & where to open 1st #PhysicalDigital #WUaSEducationalServicesStores @WUaSPress for outreach? #WUaSAccreditation -
12/2023-1/2024 @WorldUnivAndSch #WUaSLegoRobotics & for free #MITOCW-centric wiki #freeWUaSdegrees, a flagship #PhysicalDigital large #WUaSEducationalServicesStores in recently closed Walmart in #WaterworksMall #PghPA Donating to #Unitarian Universalist Church & #Quaker Meeting ~
Tech News Sun 7/6/25 & the Big Ugly Bill ... an opportunity for WUaS even?
How Healthcare Cuts in the ‘Big, Beautiful Bill’ Will Affect Americans Millions will lose Medicaid coverage, hospitals’ uncompensated work will increase and insurers will lose big business
The "Big Ugly Bill," officially named "One Big Beautiful Bill Act," is a sweeping domestic policy bill passed by the House of Representatives. It includes significant tax cuts, boosts spending on immigration enforcement and the military, and imposes steep cuts to social safety net programs like Medicaid and SNAP (food assistance). The bill is projected to increase the national debt by $3.3 trillion over a decade and result in 11.8 million more people losing health coverage, according to NBC News.
Here's a breakdown of the key points:
Tax Cuts:
The bill extends existing tax cuts from Trump's first term and includes new ones, primarily benefiting high-income individuals and corporations.
Spending Increases:
Funding is increased for immigration enforcement, the military, and potentially a "Golden Dome" defensive system.
Cuts to Social Safety Nets:
The bill slashes funding for Medicaid, SNAP, and clean energy initiatives. These cuts are intended to offset the cost of the tax cuts.
Impact on Healthcare:
At least 10 million people could lose access to Medicaid, and the bill's budget deficit could trigger further cuts to Medicare.
Impact on Food Assistance:
Millions of people, including children, could lose access to SNAP benefits.
Impact on Energy Sector:
The bill is criticized for harming the clean energy sector by repealing tax credits, eliminating climate protections, and potentially costing thousands of clean energy jobs.
Deficit Increase:
The bill is projected to add $3.3 trillion to the national debt over ten years.
Political Implications:
The bill has been heavily criticized by Democrats, who argue it benefits the wealthy at the expense of vulnerable populations and the environment
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key points about the big ugly bill washington dc re education too
The term "Big Ugly Bill" in the context of Washington D.C. education refers to a comprehensive Republican legislative proposal that includes significant changes to federal education programs.
Key Points Regarding Education Aspects:
Increased Student Loan Payments: The bill proposes a single income-driven repayment plan that could lead to higher monthly payments for many student loan borrowers, potentially increasing them by almost $200 for the average borrower.
Elimination of Certain Federal Loans: The bill eliminates new subsidized loans for all undergraduate students and new Grad PLUS loans. It also caps Parent PLUS loans at $50,000 and requires undergraduate students to exhaust their unsubsidized loans before parents can utilize Parent PLUS loans. This could force students to rely on potentially "predatory, unregulated private loans".
Reduced Access to Higher Education: Higher education experts express concerns that the bill's provisions, like the loan caps, could make college less affordable and accessible for many students, potentially hindering America's ability to compete globally. Some experts specifically note that the proposed loan caps could prevent students without other financial resources from pursuing graduate and professional degrees.
School Vouchers and Public School Funding: The "Big Ugly Bill" aims to establish a nationwide federal school voucher program, which would force taxpayers to fund private schools and homeschools. This could divert funding and resources away from public schools, where the majority of students are enrolled. This program would also create tax breaks that overwhelmingly benefit wealthy individuals and corporations.
Impact on Students in Need: The bill's cuts to programs like Medicaid and SNAP could affect students' access to free school meals and other essential resources. Estimates suggest that nearly 300,000 children could lose direct certification for free meals due to cuts in SNAP benefits.
Potential for Predatory Private Loan Market: By eliminating and capping federal loans, the bill might push students towards "predatory, unregulated private loans" to finance their education.
Concerns about Accountability: Some higher education institutions are worried about a proposed "risk-sharing" provision in the bill. This could negatively impact many work colleges, potentially requiring them to make payments to the federal government even if their student loan debt is below average, according to the Work Colleges Consortium.
It's important to note that the term "Big Ugly Bill" is a moniker used by Democrats who oppose the legislation. Republicans refer to it as the "Big Beautiful Bill" and frame it as a way to stimulate the economy through tax cuts and to reform social programs